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| 1 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 2 | Pore Structure Characteristics of Baking-Free Slag-Sludge Bricks and Its Correlations to Mechanical Properties显示文摘In order to explore the relationship between the macroscopic properties and pore structure characteristics of baking-free slag-sludge bricks,the compressive strength and water absorption rate using aluminum industrial slag and sludge of different substitution rates were tested.Optical instruments and image analysis software were used to measure the parameters of the pore structure.Specifically,a fractal model was built based on the fractal theory,in which the fractal dimension was used as the characteristic index of the pore structure to analyze the correlation and interaction mechanism between the fractal dimension and the macroscopic mechanical properties.Based on this study,conclusions were drawn as follows:(1)The plane pore structure of baking-free bricks shows good fractal characteristics.With the increase of the aluminum industrial slag content,the fractal dimension becomes smaller and the pore structure develops well;with the increase of the sludge content,the fractal dimension becomes larger and the pore structure becomes worse;(2)As the fractal dimension of the plane pore structure increases,the compressive strength of baking-free bricks falls,and the porosity and water absorption rise;(3)The optimum content of baking-free slag-sludge bricks is aluminum industrial slag 30%and sludge 10%.After 7 days of curing,baking-free bricks boast higher performance,and fully meet the performance requirements of solid concrete bricks(MU40),which can reduce time costs,and enhance enterprise revenue. | Lei Guo Pingping Chen Lixia Guo Zhilong Xue Zi Guan Mingru Li | 2021 | Journal of Renewable Materials2021，9，10： | 2 |
| 3 | Hyers-Ulam stability of linear differential equations of first order 显示文摘 | Wang Guangwa Zhou Mingru Sun Li | 2008 | Appl Math Lett2008，21，： | 1 |
| 4 | A facile synthesis of graphite/silicon/graphene spherical composite anode for lithium-ion batteries显示文摘 | Lei Gan Huajun Guo Zhixing Wang Xinhai Li Wenjie Peng Jiexi Wang Silin Huang Mingru Su | 2013 | Electrochimica Acta2013，，： | 1 |
| 5 | Effects of Recycled Aggregate Content on Pervious Concrete Performance显示文摘A recycled aggregate(RA)was prepared by crushing and sieving demolished discarded concrete pavements and was subsequently tested and analyzed to determine its various physical properties.On this basis,pervious concrete(PC)mix proportions were designed.Coarse RA particles with sizes of 5–10 and 10–20 mm were selected.Concrete specimens were prepared with a water–cement ratio of 0.3,an aggregate–cement ratio of 4.5,the substitute rates of RA with 0,25%,50%,75%and a single-/double-gap-graded RA mix(mass ratio of particles with sizes of 5–10 mm to particles with sizes of 10–20 mm:1:1,1:2,2:1,2:3 and 3:2).Various properties of the RA-containing PC(RPC)were determined by analyzing the compressive strength,splitting tensile strength,effective porosity,permeation coefficient and impact and abrasion resistance of the specimens.The results showed the following:The density of the RPC decreased with an increasing RA replacement ratio.The density of the RPC prepared with a double-gapgraded RA mix was lower than that prepared with a single-gap-graded RA(particle size:10–20 mm)mix.The permeation coefficient of the RPC increased with increasing porosity.The splitting tensile strength of the RPC was positively correlated with its compressive strength.The compressive strength of the RPC decreased with increasing porosity.The regression analysis showed that the impact and abrasion resistance of the RPC increased with increasing compressive strength.In addition,all of the RPC specimens met the strength and permeation requirements.This study can provide theoretical support for the application of RPC. | Lei Guo Zi Guan Lixia Guo Weiping Shen Zhilong Xue Pingping Chen Mingru Li | 2020 | Journal of Renewable Materials2020，8，12： | 1 |
| 6 | Ti-MOF-based biosafety materials for efficient and long-life disinfection via synergistic photodynamic and photothermal effects显示文摘Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic framework(MOF)derived nanocarbon(C-Ti-MOF)as a biosafety material for synergistic sterilization of pathogenic bacteria via efficient photodynamic catalysis and robust photothermal effects.The C-Ti-MOF consists of abundant TiO_(2) nanodots embedded in graphitic carbon frameworks.Under visible light irradiation,TiO_(2) nanodots can catalyze H_(2)O_(2) and O_(2) to produce superoxide anion(•O_(2)^(–))and singlet oxygen(1O2),respectively.Meanwhile,under near-infrared irradiation(NIR),C-Ti-MOF can generate massive heat to destroy bacterial membranes.Systematic antibacterial experiments reveal that the C-Ti-MOF nanoagents have a long-lasting and nearly 100%bactericidal ratio at an extremely low dose(0.16 mg/mL),which is much better than the state-of-the-art TiO_(2)(Commercial TiO_(2)(P25),0.64 mg/mL).Furthermore,the C-Ti-MOF can be electrospun into an antibacterial nanofiber membrane via mixing with polymeric matrix for treating bacteriacontaminated wastewater,and the membranes possess integrated antibacterial activity and excellent biocompatibility.Our study demonstrates a promising Ti-MOF-based biosafety material for efficient and long-life disinfection,which may stimulate new research in MOF-related biological applications in various disciplines ranging from water decontaminations to nanotherapeutics. | Lan Xie Heng Yang Xizheng Wu Liyun Wang Bihui Zhu Yuanjiao Tang Mingru Bai Ling Li Chong Cheng Tian Ma | 2022 | Biosafety and Health2022，4，2： | 0 |
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