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| 1 | Interleukin-10 modified dendritic cells induce allo-hyporesponsiveness and prolong small intestine allograft survival显示文摘AIM: To investigate whether TL-10-transduced dendritic cells (DCs) could induce tolerogenicity and prolong allograft survival in rat intestinal transplantation.METHODS: Spleen-derived DCs were prepared and genetically modified by hTL-10 gene. The level of IL-10 expression was quantitated by ELTSA. DC function was assessed by MTT in mixed leukocyte reaction. Allogeneic T-cell apoptosis was examined by flow cytometric analysis. Seven days before heterotopic intestinal transplantation, 2x106 donor-derived IL-10-DC were injected intravenously, then transplantation was performed between SD donor and Wistar recipient.RESULTS: Compared with untransduced DC, IL-10-DC could suppress allogeneic mixed leukocyte reaction (MLR). The inhibitory effect was the most striking with the stimulator/effector (S/F) ratio of 1:10. The inhibition rate was 33.25 %,41.19 % (P<0.01) and 22.92 % with the S/E ratio of 1:1,1:10 and 1:50 respectively. At 48 hours and 72 hours by flow cytometry counting, apoptotic T cells responded to IL-10-DC in MLR were 13.8 % and 30.1%, while untransduced group did not undergo significant apoptosis (P<0.05). IL-10-DC pretreated recipients had a moderate survival prolongation with a mean allograft survival of 19.8 days (P<0.01),compared with 7.3±2.4 days in control group and 8.3±2.9days in untransduced DC group. Rejection occurred in the control group within three days. The difference between untreated DC group and control group was not significant.CONCLUSION: IL-10-DC can induce allogenic T-cell hyporesponsiveness in vitro and apoptosis may be involved in it. IL-10-DC pretreatment can prolong intestinal allograft survival in the recipient. | MinZhu Ming-FaWei FangLiu Hui-FenShi GuoWang | 2003 | World Journal of Gastroenterology2003，9，11： | 10 |
| 2 | LGH: a fast and accurate algorithm for single individual haplotyping based on a two-locus linkage graph显示文摘 | XIE Minzhu WANG Jianxin CHEN Xin | 2015 | IEEE/ACM Transactions on Computational Biology and Bioinformatics2015，12，6： | 1 |
| 3 | Multifunctional Mesoporous Nanoellipsoids for Biological Bimodal Imaging and Magnetically Targeted Delivery of Anticancer Drugs显示文摘 | YuChen HangrongChen ShengjianZhang FengChen LingxiaZhang JiaminZhang MinZhu HuixiaWu LiminGuo JingweiFeng JianlinShi | 2010 | Adv Funct Mater2010，，2： | 1 |
| 4 | Research on parameterized algorithms of the individual haplotyping problem显示文摘 | XIE Minzhu CHEN Jian'er WANG Jianxin | 2007 | Journal of Bioinformatics and Computational Biology2007，5，3： | 1 |
| 5 | Research on Parameterized Algorithms of the Individual Haplotyping Problem显示文摘 | Xie Minzhu Chen Jian'er Wang Jianxin | 2007 | Joumal of Bioinformatics and Computational Biology2007，5，3： | 1 |
| 6 | Astrogalosides inhibit proliferation of hepatic stellate cells through inducing apoptosis and blocking cell cycle显示文摘 | Qiang w Yan Y Minzhu C | 2004 | Shock2004，，： | 1 |
| 7 | Application of Radioligand Receptor Binding Assays in the Search for CNS Activepeinciples from Chinese Medicinal Plants显示文摘 | Minzhu Norman G Browery Pamela M Greengrass | 1996 | J Ethnopharmacology1996，54，： | 1 |
| 8 | Micro-geomorphology determined community structure of biological soil crusts at small scale显示文摘 | Li Xinrong He Minzhu Zerbe S | 2010 | Earth Surface Processes and Landforms2010，35，： | 1 |
| 9 | A Convenient Method for Synthesis of Novel Cyclic Ethers (1R,2R,3R,5S,7S,9R,12R)-3-(t-Butyldimethylsilyl)oxy-7-methoxymethyl-oxy-2,10-dimethyl-12-oxatricyclo [7.2.1.0^(5,12)] dodecane显示文摘Novel cyclic esters (1R, 2R, 3R, 5S, 7S, 9R, 12R)-3-(t-butyldimethylsilyl)oxy-7- methoxymethyloxy-2, 10-dimethyl-12-oxatricyclo [7.2.1.05,12] dodecane were prepared when their precursor 1 was treated with SOCl2/pyridine. A plausible mechanism was hypothesized. | JieYAN MinZHU | 2005 | Chinese Chemical Letters2005，16，4： | 0 |
| 10 | Entrepreneurial Growth and the Perceived Quality of Environmental Factors in China显示文摘The growth of entrepreneurship in China has been phenomenal since the open-door policyin 1978. Small- and medium-sized enterprises (SMEs) have increasingly played an importantrole in the Chinese economy, accounting for about 50 percent of the total GDP in 2001.Nonetheless, a few studies have examined what counts for such rapid growth ofentrepreneurship in China. This study focuses on identifying environmental factors relatedto the success and failure of entrepreneurship in China. Based on a survey of 117 SMEexecutives in Sichuan province, the survey results show that positive social acceptance,risk-taking attitudes and infrastructure adequacy were perceived as most facilitating factors,while market development and exploitation, and adopting low cost strategy were successfactors. The results also reveal that lack of capital and over-competition within the industrywas the key reasons for SME failures. | MinZhu HongxinZhao | 2005 | China & World Economy2005，13，4： | 0 |
| 11 | Single-Wall Carbon Nanotube Growth from Graphite Layers-a Tight Binding Molecular Dynamics Simulation显示文摘The growth of single-wall carbon nanotube from graphite layers is studied by tight binding molecular dynamics simulation. Given temperature of 2500 K or 3500 K and an interval of 0.25 nm for the two layers of graphite, a single-wall carbon nanotube with a zigzag shell will be produced. On the other conditions the carbon nanotube cannot grow or grows with too many defects. All carbon nanotube ends have pentagons which play an important role during the tube ends closing. | YuntuanFANG MinZHU YongshunWANG | 2003 | Journal of Materials Science & Technology2003，19，6： | 0 |
| 12 | Stereological analyses of neuropathology linked to motor system impairments in harlequin (Hq) mutant mice显示文摘 | MinZhu JacekMamczarz ChristopherQuigley PeterR.Mouton DonaldKIngraim | 2004 | 中国组织化学与细胞化学杂志2004，13，3： | 0 |
| 13 | PubExplorer:An interactive analytical system for visualizing publication data显示文摘With the intersection and convergence of multiple disciplines and technologies,more and more researchers are actively exploring interdisciplinary cooperation outside their main research fields.Facing a new research field,researchers often hope to quickly learn what is being studied in this field,which research points are receiving high attention,which researchers are studying these research points,and then consider the possibility of collaborating with core researchers on these research points.In addition,students who are preparing for academic further education usually conduct research on mentors and mentors’research platforms,including academic connections,employment opportunities,etc.In order to satisfy these requirements,we(1)design a research point state map based on a science map to help researchers and students understand the development state of a new research field;(2)design a bar-link author-affiliation information graph to help researchers and students clarify academic networks of scholars and find suitable collaborators or mentors;(3)designs citation pattern histogram to quickly discover research achievements with high research value,such as the Sleeping Beauty papers,recently hot papers,classic papers and so on.Finally,an interactive analytical system named PubExplorer was implemented with IEEE VIS publication data,and its effectiveness is verified through case studies. | Minzhu Yu Yang Wang Xiaomin Yu Guihua Shan Zhong Jin | 2023 | Visual Informatics2023，7，3： | 0 |
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