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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | High temperature reduces apple fruit colour via modulation of the anthocyanin regulatory complex显示文摘 | Wang L K Micheletti D Palmer J Volz R Lozano L Espley R Hellens R P Chagn6 D Rowan D D Troggio M Iglesias I Allan A C | 2011 | Plant Cell & Environment2011，34，： | 1 |
| 3 | Evidence for a cross-talk between human neutrophils and Th17 cells显示文摘 | Pelletier M Maggi L Micheletti A | 2010 | Blood2010，115，2： | 1 |
| 4 | Multiplicity results for a fourth-order semilinear elliptic problem显示文摘 | Micheletti A M Pistoia A | 1998 | Nonlinear Analysis1998，31，7： | 1 |
| 5 | Assessment of ecological risk from bioaccumulation of PCDD/Fs and dioxin-like PCBs in a coastal lagoon显示文摘 | MICHELETTI C CRITTO A MARCOMINI A | 2007 | Environment International2007，33，： | 1 |
| 6 | Origin of a polyploid accession of Brachiaria humidicola (Poaceae:Panicoideae:Paniceae)显示文摘 | BOLDRINI K R MICHELETTI P L GALLO P H MENDES-BONATO A B | 2009 | Genetic and Molecular Research2009，8，3： | 1 |
| 7 | Toll-like receptor-3-activated human mesenchymal stromal ceils significantly prolong the survival and function of neutro- phils显示文摘 | CASSATELLA M A MOSNA F MICHELETTI A | 2011 | StemCells2011，29，6： | 1 |
| 8 | Toll-like receptor-3- activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils显示文摘 | Cassatella MA Mosna F Micheletti A | 2011 | Stem Cells2011，29，6： | 1 |
| 9 | Transcatheter closure of perimembra- nous ventricular septal defects: early and long-term re- sults显示文摘 | Butera G Carminati M Chessa M Piazza L Micheletti A Negura D G | 2007 | J Am Coll Cardiol2007，50，： | 1 |
| 10 | Complexity of cyanobacterial exopolysaccharides: Composition, structures, inducing factors and putative genes involved in their biosynthesis and assembly 显示文摘 | Pereira S Zille A Micheletti E | 2009 | FEMS Microbiology Reviews2009，33，5： | 1 |
| 11 | Evidence for a cross-talk between human neutrophils and Th17 cells显示文摘 | Pelletier M Maggi L Micheletti A | 2010 | {H}Blood2010，，02： | 1 |
| 12 | Nontrivial Solutions for Some Fourth Order Semilinear Elliptic Problems显示文摘 | Pistoia A | 1998 | Nonlinear Anal1998，34，4： | 1 |
| 13 | Multiplicity Results for a Fourth-Order Semilinear Elliptic Problem显示文摘 | Pistoia A | 1998 | Nonlinear Anal1998，31，7： | 1 |
| 14 | Nontrivial solutions for some fourth order semilinear elliptic problems显示文摘 | Micheletti A M Pistoia A | 1998 | Nonlinear Analysis1998，34，4： | 1 |
| 15 | A High quality draft consensus sequence of the genome of a heterozygous grapevine variety显示文摘 | VELASCO R ZHARKIKH A TROGGIO M CARTWRIGHT DA CESTARO A PRUSS D PINDO M FITZGERALD LM VEZZULLI S REID J MALACARNE G ILIEV D COPPOLA G WARDELL B MICHELETTI D MACALMA T FACCI M MITCHELL JT PERAZZOLLI M ELDREDGE G GATTO P OYZERSKI R MORETTO M GUTIN N STEFANINI M CHEN Y SEGALA C DAVENPORT C DEMATYTE L MRAZ A BAT- TILANA J STORMO K COSTA F TAO Q SI-AMMOUR A HARKINS T LACKEY A PERBOST C TAILLON B STELLA A SOLOVYEV V FAWCETY JA STERCK L VANDEPOELE K GRANDO SM TOPPO S MOSER C LANCHBURY J BOGDEN R SKOLNICK M SGARAMELLA V BHATNAGAR SK FONTANA P GUTIN A VAN DE PEER Y SALAMINI F VIOLA R | 2007 | PLoS One2007，2，： | 1 |
| 16 | Diverse toxicity associated with cardiac Na^+/K^+ pump inhibition:evaluation of electrophysiological mechanisms显示文摘 | Rocchetti M Besana A Mostacciuolo G Ferrari P Micheletti R Zaza A | 2003 | J Pharmacol Exp Ther2003，305，2： | 1 |
| 17 | Toll-like recep- tor-3-activated human mesenehymal stromal cells significantly prolong the survival and function of neutrophils显示文摘 | Cassatella M A Mosna F Micheletti A | 2011 | Stem Cells2011，29，6： | 1 |
| 18 | Two applications of a three critical points theorem显示文摘 | Micheletti A M | 1996 | J Diff Eq1996，132，： | 1 |
| 19 | Stochastic geometric models, and related statistical issues in tumour-induced angiogenesis 显示文摘 | Capasso V Micheletti A Morale D | 2008 | Math Biosci2008，214，： | 1 |
| 20 | The lifespan of major histocompatibility complex class I/peptide complexs determines the efficiency of cytotoxic T-lymphocytes responses显示文摘 | Micheletti F Bazzaro M Canella A | 1999 | Immunology1999，96，3： | 1 |
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