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| 1 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 2 | Synthesis of dental resins using diatomite and nano-sized SiO_2 and TiO_2 | Xiaoli Miao a,Meifang Zhu a,Yaogang Li b,Qinghong Zhang b,Hongzhi Wang a a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China b Engineering Research Center of Advanced Glasses Manufacturing Technology,MOE,Donghua University,Shanghai 201620,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 3 |
| 3 | A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer显示文摘 | Hao B Miao X Li Y | 2006 | Oncogene2006，25，25： | 1 |
| 4 | Photodegradation of 2,2',5,5'-tetrachlorobiphenyl in hexane 显示文摘 | Miao X S Chu S G Xu X B | 1996 | Bull Environ Contam Toxicol1996，72，4： | 1 |
| 5 | Effect of recombinant prothymosin alpha on secretion of IFN-gamma, IFN-alpha and TNF-alpha in vitro显示文摘 | Qiu L Guo B Y Miao H | 2002 | Yao Xue Xue Bao2002，37，5： | 1 |
| 6 | Involvement of Gluta- mate Transportant-1 in Neuroprotection anginst Global Brain Ische- mia Reperfusion Injury Induced by Postconditioning in Rats 显示文摘 | Zhang W Miao Y Zhou S Wang B | 2010 | Int J Mol Sci2010，11，： | 1 |
| 7 | Characterization of polyphenol oxidase from litchi pericarp using ( - ) - epicatechin as substrate 显示文摘 | Liu L Can S Xie B Sun Z Li X Miao W | 2007 | Journal of Agriculture and Food Chemistry2007，55，17： | 1 |
| 8 | Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population显示文摘 | Wang B Miao Z Liu S | 2010 | Hum Genet2010，127，2： | 1 |
| 9 | The diversity of the DnaJ/Hsp40 family,the crucial partners for Hsp70 chaperones显示文摘 | Qiu X B Shao Y M Miao S | 2006 | Cellular and Molecular Life Sciences2006，63，22： | 1 |
| 10 | Transforming agriculture in China:From solely high yield to both high yield and high resource use efficiency显示文摘 | Shen J B Cui Z L Miao Y X | 2013 | Global Food Security2013，2，1： | 1 |
| 11 | Effect of pullulanase debranching and recrystallization on structure and digestibility of waxy maize starch 显示文摘 | Miao M Jiang B Zhang T | 2009 | Carbohydrate Polymers2009，76，2： | 1 |
| 12 | Propagation and decay of forced and free Rossby waves in off-equatorial ocean显示文摘 | Qiu B Miao W Muller P | 1997 | Journal of Physical Oceanography1997，27，： | 1 |
| 13 | Generation of multiple fame-sold-X-receptor isoforms through the use of ahemative promoters 显示文摘 | Huber R M Murphy K Miao B | 2002 | Gene2002，290，12： | 1 |
| 14 | Evaluation of different proeedures to interpolate particle-size distribution in black soils显示文摘 | Miao C Y Liu B Y Gao Y | 2008 | International Journal of Sustainable Develop & World Ecology2008，15，： | 1 |
| 15 | Overexpression of △1-pyrroline-5-carboxylate synthytase increase proline production and confers osmostolerance in transgenic plants显示文摘 | Kishor P B K Hong Z Miao GH | 1995 | Plant physiol1995，108，： | 1 |
| 16 | Overexpression of △1-pyrroline-5-carboxylate synthetase increases proline over production and confers osmo-tolerance in transgenic plants 显示文摘 | Kavi Kishor P B K Hong Z Miao G | 1995 | Plant Physiology1995，108，4： | 1 |
| 17 | Fluorescent chemosensor based on the conjugated polymer incorporating 2,2'- bipyridyl moiety for transition metal ions 显示文摘 | Miao Q Huang X B Cheng Y Q | 2009 | JAppl Polym Sci2009，111，6： | 1 |
| 18 | PYDF-HFP-based porous po- lymer electrolyte membranes for lithium-ion batteries显示文摘 | Miao R Y Liu B W Zhu Z Z | 2008 | Journal of Power Sources2008，184，2： | 1 |
| 19 | Dis- tribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada 显示文摘 | Metcalfe C D Miao Xiu Sheng Koening B G | 2003 | Environmental Toxicology And Chemistry2003，22，12： | 1 |
| 20 | Differentialexpression of microRNA species in humangastric cancer versus non-tumorous tissues显示文摘 | Guo J Miao Y Xiao B | 2009 | J Gastroenterol Hepatol2009，24，4： | 1 |
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