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| 1 | Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections显示文摘Antibiotic-associated diarrhea(AAD) and Clostridum difficile infections(CDI) have been well studied for adult cases, but not as well in the pediatric population. Whether the disease process or response to treatments differs between pediatric and adult patients is an important clinical concern when following global guidelines based largely on adult patients. A systematic review of the literature using databases Pub Med(June 3, 1978-2015) was conducted to compare AAD and CDI in pediatric and adult populations and determine significant differences and similarities that might impact clinical decisions. In general, pediatric AAD and CDI have a more rapid onset of symptoms, a shorter duration of disease and fewer CDI complications(required surgeries and extended hospitalizations) than in adults. Children experience more community-associated CDI and are associated with smaller outbreaks than adult cases of CDI. The ribotype NAP1/027/BI is more common in adults than children. Children and adults share some similar risk factors, but adults have more complex risk factor profiles associated with more co-morbidities, types of disruptive factors and a wider range of exposures to C. difficile in the healthcare environment. The treatment of pediatric and adult AAD is similar(discontinuing or switching the inciting antibiotic), but other treatment strategies for AAD have not been established. Pediatric CDI responds better to metronidazole, while adult CDI responds better to vancomycin. Recurrent CDI is not commonly reported for children. Prevention for both pediatric and adult AAD and CDI relies upon integrated infection control programs, antibiotic stewardship and may include the use of adjunctive probiotics. Clinical presentation of pediatric AAD and CDI are different than adult AAD and CDI symptoms. These differences should be taken into account when rating severity of disease and prescribing antibiotics. | Lynne Vernice Mc Farland Metehan Ozen Ener Cagri Dinleyici Shan Goh | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Saccharomyces boulardii CNCM I-745 in different clinical conditions显示文摘 | Ener Cagri Dinleyici Ates Kara Metehan Ozen Yvan Vandenplas | 2014 | Expert Opinion on Biological Therapy2014，，11： | 1 |
| 3 | Real-time computerized video enhancement for minimally invasive fetoscopic surgery显示文摘Background:The only definitive treatment for twin-to-twin transfusion syndrome is minimally invasive fetoscopic surgery for the selective coagulation of placental blood vessels.Fetoscopic surgery is a technically challenging operation,mainly due to the poor visibility conditions in the uterine environment.We present the design of an algorithm for the computerized enhancement of fetoscopic video and show that the enhanced video increases the ability of human users to identify blood vessels within fetoscopic video rapidly and accurately.Methods:A computer algorithm for the enhancement of fetoscopic video frames was created.First,optical fiber artifacts were removed via a modification of unsharp masking.Second,image contrast was increased via Contrast Limited Adaptive Histogram Equalization(CLAHE).Third,the effect of contrast enhancements on stationary features was removed by normalizing to a windowed mean of the video frames.Fourth,color information was reincorporated by combining the mean-normalized result with the unnormalized contrast enhanced image using the soft light blending algorithm.Medical trainees(n?16)were recruited into a study to validate the algorithm.Subjects were shown enhanced or unenhanced fetoscopic video frames on a screen and were asked to identify whether a randomly placed marker fell on a blood vessel or on background.The accuracy of their responses was recorded.Results:On the subset of images where subjects had the lowest mean accuracy in identifying the placement of the marker,subjects performed better when viewing video frames enhanced by the computer(accuracy 74.27%;SE 0.97)than when viewing unenhanced video frames(accuracy 63.78%;SE 2.79).This result was statistically significant(p<0.01).Conclusion:Real-time computerized enhancement of fetoscopic video has the potential to ease the readability of video in poor lighting conditions,thus providing a benefit to the surgeon intraoperatively. | Praneeth Sadda John Onofrey Metehan Imamoglu Xenophon Papademetris Bilal Qarni Mert Ozan Bahtiyar | 2018 | Laparoscopic, Endoscopic and Robotic Surgery2018，1，2： | 1 |
| 4 | Causes of failure in removing calcium in microealcification-only Lesions using l 1-gauge stereotactic vacuum-assisted breast biopsy显示文摘 | Hatice GOmii Metehan GtimO Haresh Devalia | 2012 | Diagn Interv Radiol2012，18，： | 1 |
| 5 | Effect of acidic etching and fluoride treatment on corrosion performance in Mg alloy AZ91D (MgAlZn)显示文摘 | Metehan C. Turhan Robert Lynch Manuela S. Killian Sannakaisa Virtanen | 2009 | Electrochimica Acta2009，，1： | 1 |
| 6 | Electrochemical polymerization and characterization of polypyrrole on Mg–Al alloy (AZ91D)显示文摘 | Metehan C. Turhan M. Weiser Manuela S. Killian B. Leitner S. Virtanen | 2010 | Synthetic Metals2010，，3： | 1 |
| 7 | Maternal serum and fetal cord blood irisin levels in gestational diabetes mellitus显示文摘 | Mehmet Aytac Yuksel Mahmut Oncul Abdullah Tuten Metehan Imamoglu Abdullah Serdar Acikgoz Mine Kucur Riza Madazli | 2013 | Diabetes Research and Clinical Practice2013，，： | 1 |
| 8 | Exploring the role of metacognition in obsessive–compulsive and anxiety symptoms显示文摘 | Metehan Irak Ahmet Tosun | | 0，，： | 1 |
| 9 | Unusual Noncommunicating Isolated Enteric Duplication Cyst in Adults显示文摘 | Metehan Gümü? Murat Kapan Hatice Gümü? Akin ?nder Sadullah Girgin A. Andoh | 2011 | Gastroenterology Research and Practice2011，，： | 1 |
| 10 | RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway显示文摘 | Direna Alonso-Curbelo Erica Riveiro-Falkenbach Eva Pérez-Guijarro Metehan Cifdaloz Panagiotis Karras Lisa Osterloh Diego Megías Estela Ca?ón Tonantzin G. Calvo David Olmeda Gonzalo Gómez-López Osvaldo Gra?a Víctor Javier Sánchez-Arévalo Lobo David G. Pisa | 2014 | Cancer Cell2014，，： | 1 |
| 11 | Exploring the role of metacognition inob- sessive - compulsive and anxiety symptoms 显示文摘 | Metehan Irak Ahmet Tosun | 2008 | Journal of Anxiety Disorders2008，22，： | 1 |
| 12 | Com- parison of clinical and perinatal outcomes in early-and late-onset preeclampsia显示文摘 | Riza Madazli Mehmet Ayta Yuksel Metehan | 2014 | Archives of Gynecology and Obstetrics2014，29，1： | 1 |
| 13 | Impact of sorafenib on epidural fibrosis: An immunohistochemical study显示文摘AIM To determine if sorafenib, an antineoplastic agent, could prevent the development of spinal epidural fibrosis(EF). METHODS The study used CD105 and osteopontin antibodiesin an immunohistochemical approach to quantify EF that occurred as a consequence of laminectomy in rats. Wistar albino rats(n = 16) were divided into two groups: control(L1-2 level laminectomy only) and sorafenib treatment(L1-2 level laminectomy + topical sorafenib). The animals were euthanatized after 6 wk, and the EF tissues were examined for histopathological changes after immunohistochemical staining. The EF grades were assigned to the tissues, and the treatment and control groups were compared. RESULTS The EF thickness, inflammatory cell density, and arachnoid adherences determined by light microscopy were significantly higher in the control group compared to the sorafenib-treated group. Based on fibrosis scores, the extent of EF in the treatment group was significantly lower than in the controls. Immunohistochemical staining for CD105 to identify microvessels revealed that the EF grades based on vessel count were significantly lower in the treatment group. Staining for osteopontin did not show any significant differences between the groups in terms of the extent of EF. The staging of EF based on vascular counts observed after immunohistochemical staining for CD105, but not for osteopontin, was compatible with conventional staging methods. Neither toxic effects on tissues nor systemic side effects were observed with the use of sorafenib. CONCLUSION Local administration of sorafenib significantly reduced post-laminectomy EF. Decreased neovascularization in spinal tissue may be due to the sorafenib-induced inhibition of vascular endothelial growth factor. | Osman Tanriverdi Uzay Erdogan Canan Tanik Ilhan Yilmaz Omur Gunaldi Huseyin Utku Adilay Ayca Arslanhan Metehan Eseoglu | 2018 | World Journal of Clinical Cases2018，6，9： | 0 |
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