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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Head growth in infants with hypoxic-ischemic encephalopathy: Correlation with neonatal magnetic resonance imaging显示文摘 | Mercuri E Ricci D Cowan FM | 2000 | Paediatrics2000，106，21： | 1 |
| 3 | Apolipoprotein E polymorphism and carotid artery intima-media thickness in a random sample of middle-aged men显示文摘 | Ilveskoski E Loimaala A Mercuri MF | 2000 | Atherosclerosis2000，153，1： | 1 |
| 4 | Muscle MRI in inheri- ted neuromuscular disorders: past, present, and future 显示文摘 | Mercuri E Pichiecchio A Allsop J | 2007 | J Magn Reson Imaging2007，25，2： | 1 |
| 5 | TREAT-NMD workshop: pat- tern recognition in genetic muscle diseases using muscle MRI: 25- 26 February 201 l, Rome, Italy显示文摘 | Straub V Carlier P G Mercuri E | 2012 | Neuromuscul Disord2012，22，2： | 1 |
| 6 | A short protocol for muscle MRI in children with muscular dystrophies显示文摘 | Mercuri E Pichiecchio A Counsell S | 2002 | Eur J Pae- diatr Neurol2002，6，6： | 1 |
| 7 | Neonatal cerehral infarction and visual function at school age显示文摘 | Mercuri E Anker S Guzzetta A | 2003 | Arch Dis Ctlild Fetal Neonatal Ed2003，88，： | 1 |
| 8 | General movements detect early signs of hemiplegia in term infants with neonatal cerebral infarction显示文摘 | Guzzetta A Mercuri E Rapisardi G | 2003 | Neuropediatrics2003，34，2： | 1 |
| 9 | Neonatal cerebral infarction and neuromotor outcome at school age 显示文摘 | Mercuri E Barnett A Rutherford M | 2004 | Pediatrics2004，113，： | 1 |
| 10 | Clinical and ima- ging findings in six cases of congenital nmscular dystrophy with rigid spine syndrome linked to chromosome I p ( RSMDI ) 显示文摘 | Mercuri E Talim B Moghadaszadeh B | 2002 | Neuromuscul Disord2002，12，78： | 1 |
| 11 | Head growth in infants with hypoxic-ischemic encephalopathy correlation with neonatal magnetic resonance imaging显示文摘 | Mercuri E Ricci D Cowan FM | 2000 | Pediatrics2000，106，2： | 1 |
| 12 | Green fluorescent flowers显示文摘 | MERCURI A SACCHETTI A BENEDETTI L d e | 2002 | Plant Science2002，162，： | 1 |
| 13 | Periodic lateralized epileptiform discharges (PLEDs) as early indicator of stroke in full-term newborns显示文摘 | Rando T Ricci D Mercuri E | 2000 | Neuropediatri cs2000，31，4： | 1 |
| 14 | Visual outcome in children with congential hemiplegia:correlation with MRI findings显示文摘 | Mercuri E Spano M Bruccini G | 1996 | Neuropediatrics1996，27，4： | 1 |
| 15 | Muscle MRI in Ullrich congenital muscular dystrophy and Bethlem myopathy 显示文摘 | Mercuri E Lampe A Allsop J | 2005 | Neuromuscul Disord2005，15，4： | 1 |
| 16 | UK physicians'attitudes and practices in long-term non-invasive ventilation of Duchenne Muscular Dystrophy显示文摘 | Kinali M Manzur AY Mercuri E | | Pediatric Rehabilitation0，，： | 1 |
| 17 | Muscle MRI in inherited neuromuscular disorders: past, present, and future 显示文摘 | Mercuri E Pichiecchio A Allsop J | 2007 | J Magn Reson Imaging2007，25，2： | 1 |
| 18 | Auditory processing in in fancy= do early abnormalities predict disorders of language and cognitive development? 显示文摘 | Guzzetta F Conti G Mercuri E | 2011 | Developmental Medicine Child Neurology2011，53，12： | 1 |
| 19 | General movements detect early signs of hemiplegia in term infants with neonatal cerebral infarction 显示文摘 | Guzzetta A Mercuri E Rapisardi G | 2003 | Neuropediatrics2003，34，2： | 1 |
| 20 | An effective,low-dosage, intermittent schedule of prednisolone in the long-term treatment of early cases of Duchenne dystrophy显示文摘 | Kinali M Mercuri E Main M | 2002 | Neuromuscul Disord2002，12，1： | 1 |
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