|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rice Expression Database(RED):An integrated RNA-Seq-derived gene expression database for rice显示文摘Rice is one of the most important stable food as well as a monocotyledonous model organism for the plant research community.Here,we present RED(Rice Expression Database;http://gffzzd1bc3ab4bbbc4005hff5uucu9f5vc6kv0.ffgz.tsg.suse.edu.cn),an integrated database of rice gene expression profiles derived entirely from RNA-Seq data.RED features a comprehensive collection of 284 high-quality RNA-Seq experiments,integrates a large number of gene expression profiles and covers a wide range of rice growth stages as well as various treatments.Based on massive expression profiles,RED provides a list of housekeeping and tissue-specific genes and dynamically constructs co-expression networks for gene(s) of interest.Besides,it provides user-friendly web interfaces for querying,browsing and visualizing expression profiles of concerned genes.Together,as a core resource in BIG Data Center,RED bears great utility for characterizing the function of rice genes and better understanding important biological processes and mechanisms underlying complex agronomic traits in rice. | Lin Xia Dong Zou Jian Sang Xingjian Xu Hongyan Yin Mengwei Li Shuangyang Wu Songnian Hu Lili Hao Zhang Zhang | 2017 | Journal of Genetics and Genomics2017，44，5： | 12 |
| 2 | Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis显示文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs. | Zhang Dan Wang Kaihuan Zheng Jiewen Wu Jiarui Duan Xiaojiao Ni Mengwei Liu Shuyu Zhang Bing Zhao Yi | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 3 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
| 4 | Preparation and application of a phosphorous free and non- nitrogen scale inhibitor in industrial cooling water systems显示文摘钙碳酸盐,锌(II ) 和铁(III ) 的一种新奇环境地友好的类型规模禁止者丙烯酸的 acidallylpolyethoxy 羧化物共聚物(AAAPEL ) 被综合。向 CaCO 的 AA-APEL 的反规模性质 < 潜水艇 class= “ a-plus-plus ” > 3 , 锌(II ) 和人工的冷却水里的铁(III ) 通过静态的规模抑制测试被学习。观察证明两钙碳酸盐,锌(II ) 和铁(III ) 抑制与增加 AA-APEL 的剂量增加。CaCO 的形成上的效果 < 潜水艇 class= “ a-plus-plus ” > 3 与扫描电子显微镜学(SEM ) 的联合被调查,传播电子显微镜学(TEM ) , X 光检查粉末衍射(XRD ) 分析和 fourier 分别地转变红外线的分光计。结果证明 AA-APEL 共聚物不仅影响的钙碳酸盐水晶形态学和水晶尺寸而且 crystallinity。CaCO 的结晶化 < 潜水艇 class= “ a-plus-plus ” > 当禁止者不在时的 3 是菱形的方解石水晶,而有 vaterite 晶体的方解石的混合物面对 AAAPEL 共聚物被发现。抑制机制被建议在钙或铁离子和聚乙烯乙二醇(木钉) 之间的相互作用是基本动力在使水系统凉下来制止规模的形成。 | Guangqing LIU Mengwei XUE Jingyi HUANG Huchuan WANG Yuming ZHOU Qingzhao YAO Lei LING Ke CAO Yahui LIU Yunyun BU Yiyi CHEN Wendao WU Wei SUN | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 3 |
| 5 | Fixed-Time Cooperative Tracking for Delayed Disturbed Multi-Agent Systems Under Dynamic Event-Triggered Control显示文摘Dear editor,Recently,researchers have obtained many new results about the multi-agent systems(MASs)[1]-[3].In[1],the fixed-time cooperative control(FTCC)algorithm of linear MASs with matched disturbances was proposed.The nonholonomic chained-form dynamics case was considered in[2].In[3],the output tracking problem with data packet dropout was solved for high-order MASs.Moreover,delay frequently occurs because of the non-ideal data transmission[4],and the corresponding FTCC algorithm of MASs with delay was given in[5]. | Jian Liu Yongbao Wu Mengwei Sun Changyin Sun | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，5： | 2 |
| 6 | Advanced noble-metal-free bifunctional electrocatalysts for metal-air batteries显示文摘The sluggish reaction kinetics at the oxygen cathode is one of the important issues hindering the commercialization of the metal-air batteries.Although the noble metal can be used as the high-efficiency electrocatalyst to solve the problems to some extent,the high cost and scarcity of these noble-metal catalysts have limited their application in electrocatalysis.In this review,we discussed the mecha-nisms of the ORR and OER,and proposed the principles for the bifunctional electrocatalysts firstly,and then the state-of-the-art bifunctional catalysts,including carbon-based materials and transition-metal-based materials.On the basis of that,the self-supporting 3D noble-metal-free bifunctional ORR/OER catalysts were also discussed.Finally,the perspectives for the bifunctional electrocatalysts were discussed. | Wenhao Tang Boya Li Kewei Teng Xiaodong Wang Ruiping Liu Mengwei Wu Lei Zhang Pengfei Ren Junqing Zhang Ming Feng | 2022 | Journal of Materiomics2022，8，2： | 2 |
| 7 | S100A6基因对胃癌细胞系MKN45生长增殖影响的实验研究(英文)显示文摘Objective: S100A6 (a.k.a., calcyclin) is over-expressed in several human tumors, including gastric carcinoma, human melanoma, pancreatic carcinoma, squamous cell carcinoma, malignant fibrous histiocytoma (MFH), and carcinomas of the thyroid, breast, and colon. However, little is known about the role S100A6 plays in gastric adenocarcinoma. In the present study, we intended to investigate the influence of S100A6 on the growth, proliferation, apoptosis, invasion and cell cycle of the gastric cancer cell MKN45. Methods: As an important member of S100 family, S100A6 cDNA was subcloned into a constitutive vector pcDNA3.1 followed by transfection in gastric cancer cell line MKN45 by using liposome. Then stable transfectants were selected and appraised. The apoptosis and cell cycles of these clones were analyzed by using flow cytometric assay. The growth and proliferation were analyzed by cell growth curves and colony-forming assay respectively. The S100A6 stable expression clones (MKN-S100A6) were detected and compared with their control groups respectively. Results: MKN-S100A6 grew faster than MKN45 and MKN-PC (MKN45 transfected with pcDNA3.1 vector). The cell counts of MKN-S100A6 in the fifth, sixth and seventh days were significantly more than those of control groups (P < 0.05). Cell cycle analysis showed that proportions of MKN-S100A6 in G0-G1 and G2-M were different significantly with those of its control groups respectively (P < 0.05). The apoptosis rate of MKN-S100A6 was significantly lower than those of control groups (P < 0.05). Results of colony-forming assay showed that the colon formation rate of MKN-S100A6 was higher than those of control groups (P < 0.05). Conclusion: S100A6 can promote the growth and proliferation of gastric cancer cells. It can help tumor cell maintain malignant phenotype. In gastric cancer, S100A6 could be thought as a tumor-enhancing gene in some distance, but its role could be complicated. | Lin Zhang Yanhong Hou Nan Li Mengwei Wang Benyan Wu Kai Wu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，9： | 1 |
| 8 | The Nord Stream pipeline gas leaks released approximately 220,000 tonnes of methane into the atmosphere显示文摘Sudden mega natural gas leaks of two Nord Stream pipelines in the Baltic Sea(Denmark)occurred from late September to early October 2022,releasing large amounts of methane into the atmosphere.We inferred the methane emissions of this event based on surface in situ observations using two inversion methods and two meteorological reanalysis datasets,supplemented with satellite-based observations.We conclude that approximately 220±30 Gg of methane was released from September 26 to October 1,2022. | Mengwei Jia Fei Li Yuzhong Zhang Mousong Wu Yingsong Li Shuzhuang Feng Hengmao Wang Huilin Chen Weimin Ju Jun Lin Jianwei Cai Yongguang Zhang Fei Jiang | 2022 | Environmental Science and Ecotechnology2022，，4： | 0 |
| 9 | Nanopore sequencing of African swine fever virus显示文摘Dear Editor,African swine fever(ASF)is one of the most pathogenic viral diseases in pigs caused by African swine fever virus(ASFV).The fatality rate is almost 100%,which brings huge economic losses to the hog industry in countries with epiepidemics(Galindo and Alonso,2017).China was the first Asian country to have an ASF epidemic,and it spread quickly across the country after the first epidemic was re・ported in August 2018(Ge et al.,2018).After that,Mongolia,Vietnam,Cambodia and North Korea also reported on the ASF epidemic in succession(OIE,2019). | Lijia Jia Mengwei Jiang Ke Wu Juefu Hu Yang Wang Weipeng Quan Mengchan Hao Haizhou Liu Hongping Wei Wenhui Fan Wenjun Liu Rongliang Hu Depeng Wang Jing Li Jianjun Chen Di Liu | 2020 | Science China(Life Sciences)2020，63，1： | 0 |
| 10 | A gap-free and haplotype-resolved lemon genome provides insights into flavor synthesis and huanglongbing (HLB) tolerance显示文摘The lemon(Citrus limon;family Rutaceae)is one of the most important and popular fruits worldwide.Lemon also tolerates huan-glongbing(HLB)disease,which is a devastating citrus disease.Here we produced a gap-free and haplotype-resolved chromosome-scale genome assembly of the lemon by combining Pacific Biosciences circular consensus sequencing,Oxford Nanopore 50-kb ultra-long,and high-throughput chromatin conformation capture technologies.The assembly contained nine-pair chromosomes with a contig N50 of 35.6 Mb and zero gaps,while a total of 633.0 Mb genomic sequences were generated.The origination analysis identified 338.5Mb genomic sequences originating from citron(53.5%),147.4Mb frommandarin(23.3%),and 147.1Mb frompummelo(23.2%).The genome included 30528 protein-coding genes,and most of the assembled sequences were found to be repetitive sequences.Several significantly expanded gene families were associated with plant-pathogen interactions,plant hormone signal transduction,and the biosynthesis of major active components,such as terpenoids and f lavor compounds.Most HLB-tolerant genes were expanded in the lemon genome,such as 2-oxoglutarate(2OG)/Fe(II)-dependent oxygenase and constitutive disease resistance 1,cell wall-related genes,and lignin synthesis genes.Comparative transcriptomic analysis showed that phloem regeneration and lower levels of phloem plugging are the elements that contribute to HLB tolerance in lemon.Our results provide insight into lemon genome evolution,active component biosynthesis,and genes associated with HLB tolerance. | Yixue Bao Ziyan Zeng Wei Yao Xiao Chen Mengwei Jiang Akbar Sehrish Bo Wu Charles A.Powell Baoshan Chen Jianlong Xu Xingtan Zhang Muqing Zhang | 2023 | Horticulture Research2023，10，4： | 0 |
| 11 | Design and fabrication of a series contact RF MEMS switch with a novel top electrode显示文摘Radio-frequency(RF)micro-electro-mechanical-system(MEMS)switches are widely used in communication devices and test instruments.In this paper,we demonstrate the structural design and optimization of a novel RF MEMS switch with a straight top electrode.The insertion loss,isolation,actuator voltage,and stress distribution of the switch are optimized and explored simultaneously by HFSS and COMSOL software,taking into account both its RF and mechanical properties.Based on the optimized results,a switch was fabricated by a micromachining process compatible with conventional IC processes.The RF performance in the DC to 18 GHz range was measured with a vector network analyzer,showing isolation of more than 21.28 dB over the entire operating frequency range.Moreover,the required actuation voltage was about 9.9 V,and the switching time was approximately 33μs.A maximum lifetime of 109 switching cycles was obtained.Additionally,the dimension of the sample is 1.8 mm×1.8 mm×0.3 mm,which might find application in the current stage. | Qiannan Wu Honglei Guo Qiuhui Liu Guangzhou Zhu Junqiang Wang Yonghong Cao Mengwei Li | 2023 | Nanotechnology and Precision Engineering2023，6，1： | 0 |
| 12 | Synthesis,biochemical evaluation and computational simulations of new cytochrome bc1 complex inhibitors based on N-(4-aryloxyphenyl)phthalimides显示文摘The cytochrome bc_1 complex(the bc_1 complex or complex Ⅲ) is an attractive target for the discovery of numerous pharmaceuticals and pesticides. In order to identify new lead structures for this target, a new series of molecules, N-(4-aryloxyphenyl)phthalimides, were designed and synthesized in a straightforward manner. Our design strategy was to introduce a 4-aryloxyphenyl group, a fragment which exhibited promising bc_1 complex-inhibiting properties, into the aryl group of the valuable N-arylphthalimide backbone. Afterward, the biochemical evaluation of the newly synthesized compounds was carried out,and the results implied that several compounds demonstrated good activities against succinatecytochrome reductase(SCR, a mixture of mitochondrial complex Ⅱ and the bc_1 complex). Further studies confirmed that 3e', a representative compound in this paper, was identified as an inhibitor of the bc_1 complex. Furthermore, computational simulations were also performed to better understand binding of 3e' to the enzyme complex, which indicated that 3e' should bind to the Q_o site of the bc_1 complex.Consequently, we harbor the idea that this paper can provide a solid platform for synthesis and discovery of other bc_1 complex inhibitors. | Hua Cheng Yan Fu Qing Chang Ni Zhang Mengwei Bu Yan Niu Qiongyou Wu Cheng Chen Francis Verpoort | 2018 | Chinese Chemical Letters2018，29，12： | 0 |
| 13 | Evolution of the North Atlantic Current and Barents Ice Sheet as revealed by grain size populations in the northern Norwegian Sea during the last 60 ka显示文摘The grain size distribution of bulk sediment samples was decomposed in a core to reconstruct paleoceanographic evolution over the past 60 ka in the northern Norwegian Sea.The results show that sediments consisted of 3–4 grain populations derived from the North Atlantic Current(NAC)and Barents Ice Sheet(BIS).The grain size data suggest three palaeoceanographic evolution stages:(1)an environment affected by BIS and NAC and changed with the interstadial/stadial transition in phase with the Greenland ice-core record at 60–31 ka BP,during which discharge of icebergs and the content of the coarsest population containing ice-rafted debris(IRD)in the sediments increased significantly during stadial,while the fine silt population containing volcanic glasses increased with the enhancement of NAC during the interstadial;(2)an extreme environment controlled by BIS at31–13 ka BP.BIS reached to its maximum at about 31 ka BP and the turbid plumes that formed at the leading edge of BIS contributed to a significant increase in the clayey population in sediments.Icebergs drained into the northern Norwegian Sea with periodical calving of the BIS at 31–19 ka BP.Subsequently,the ablation of the BIS discharged massive floods with clayey sediments and icebergs into the Norwegian Sea at 19–13 ka BP,resulting in a constant increase in clay and IRD in sediments;and(3)a marine environment similar to the present one under the strong influence of NAC following the complete melting of the BIS after 13 ka BP,NAC is the dominant transport agent and no IRD occurred in sediments.The fine silt populations containing volcanic glasses transported by NAC significantly increased. | Weiguo Wang Mengwei Zhao Yanguang Liu Min Jiang Chengqiang Wu Yang Liu | 2021 | Acta Oceanologica Sinica2021，40，10： | 0 |
| 14 | Enhanced superelasticity of Cu-Al-Ni shape memory alloys with strong orientation prepared by horizontal continuous casting显示文摘The preparation of large-scale Cu-Al-Ni shape memory alloys with excellent microstructure and texture is a significant challenge in this field.In this study,large-scale Cu-Al-Ni shape memory alloy(SMA)slabs with good surface quality and strong orientation were prepared by the horizontal continuous casting(HCC).The microstructure and mechanical properties were compared with the ordinary casting(OC)Cu-Al-Ni alloy.The results showed that the microstructure of OC Cu-Al-Ni alloy was equiaxed grains with randomly orientation,which had no obvious superelasticity.The alloys producedby Hcchad herringbone grains withstrong orientation near(100)and the cumulative tensile superelasticity of 4.58%.The superelasticity of the alloy produced by HCC has been improved by 4-5 times.This work has preliminarily realized the production of large-scale Cu-Al-Ni SMA slab with good superelasticity,which lays a foundation forexpanding the industrial production and application of Cu-based SMAs. | Mengwei WU Yu XIAO Zhuofan HU Ruiping LIU Chunmei MA | 2022 | Frontiers of Materials Science2022，16，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员