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您的检索式：作者名="Mengde Zhang"
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| 1 | A Portable Noncontact Profile Scanning System for Aircraft Assembly显示文摘Three-dimensional(3D)profile scanning plays a crucial role in the inspection of assembled large aircraft.In this paper,to achieve noncontact automatic measurements of the high-reflective profiles of large-scale curved parts and components,an automated noncontact system and method with high accuracy and high efficiency are presented.First,a hybrid 3D coordinate measurement system based on proximity sensors and cameras is proposed to obtain noncontact measurements while avoiding the influence of high reflection on the measurement accuracy.A hybrid measurement model that combines the one-dimensional distances measured by the proximity sensors and the 3D information obtained by cameras is proposed to determine high-accuracy 3D coordinates of the measured points.Then,a profile-driven 3D automated scanning method and strategy are designed to rapidly scan and reconstruct the profile within the effective range without scratching the profile or exceeding the measurement range of the proposed system.Finally,experiments and accuracy analyses are performed in situ on an assembled tailplane panel(approximately 1760 mm×460 mm).The automated scanning process is completed in a timeframe of 208s with an average error of less than 0.121 mm for profile reconstruction.Therefore,the proposed method is promising considering both the high accuracy and high efficiency requirements of profile inspections for large aircraft. | Bing Liang Wei Liu Kun Liu Mengde Zhou Yang Zhang Zhenyuan Jia | 2022 | Engineering2022，8，8： | 2 |
| 2 | Reciprocal interaction between vascular niche and sweat gland promotes sweat gland regeneration显示文摘The incorporation of vasculature is known to be effective in tissue or organ functional regeneration.However,a vague understanding of the interaction between epidermal appendages and their vascular niches is a foremost obstacle to obtaining sweat gland(SG)-specific vasculature units.Here,we map their precise anatomical con-nections and report that the interplay between SG cells(SGCs)and the surrounding vascular niche is key for glandular development and homeostasis maintenance.To replicate this interplay in vitro,we used three-dimensional(3D)bioprinting to generate reproducible SGC spheroids from differentiated adipose-derived mesenchymal stem cells(ADSCs).With dermal microvascular endothelial cells(DMECs),sacrificial templates made from poly(ε-caprolactone)(PCL)were fabricated to pattern the vascular niche.This interplay model promoted physiologically relevant vascularized glandular morphogenesis in vitro and in vivo.We identified a reciprocal regulatory mechanism for promoting SGs regeneration via contact-independent cell communication and direct cell-cell interactions between SGs and the vasculature.We envision the successful use of our approach for vascularized organ regeneration in the near future. | Xingyu Yuan Xianlan Duan Enhejirigala Zhao Li Bin Yao Wei Song Yuzhen Wang Yi Kong Shijun Zhu Fanliang Zhang Liting Liang Mengde Zhang Chao Zhang Deling Kong Meifeng Zhu Sha Huang Xiaobing Fu | 2023 | Bioactive Materials2023，，3： | 0 |
| 3 | Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo显示文摘Background:Sweat glands(SGs)have low regenerative potential after severe burns or trauma and their regeneration or functional recovery still faces many obstacles.In practice,restoring SG function requires not only the structural integrity of the gland itself,but also its neighboring tissues,especially blood vessels.Collagen triple helix repeat containing-1(CTHRC1)was first identified in vascular repair,and increasing reports showed a close correlation between cutaneous appendage specification,patterning and regeneration.The purpose of the present study was to clarify the role of CTHRC1 in SGs and their adjacent microvessels and find therapeutic strategies to restore SG function.Methods:The SGs and their adjacent microvascular network of Cthrc^(1−/−)mice were first inves-tigated using sweat test,laser Doppler imaging,tissue clearing technique and transcriptome analysis.The effects of CTHRC1 on dermal microvascular endothelial cells(DMECs)were further explored with cell proliferation,DiI-labeled acetylated low-density lipoprotein uptake,tube for-mation and intercellular junction establishment assays.The effects of CTHRC1 on SG function restoration were finally confirmed by replenishing the protein into the paws of Cthrc(1−/−)mice.Results:CTHRC1 is a key regulator of SG function in mice.At the tissue level,Cthrc1 deletion resulted in the disorder and reduction of the microvascular network around SGs.At the molecular level,the knockout of Cthrc1 reduced the expression of vascular development genes and functional proteins in the dermal tissues.Furthermore,CTHRC1 administration considerably enhanced SG function by inducing adjacent vascular network reconstruction.Conclusions:CTHRC1 promotes the development,morphogenesis and function execution of SGs and their neighboring vasculature.Our study provides a novel target for the restoration or regeneration of SG function in vivo. | Xingyu Yuan Xianlan Duan Zhao Li Bin Yao Enhejirigala Wei Song Yi Kong Yuzhen Wang Fanliang Zhang Liting Liang Shijun Zhu Mengde Zhang Chao Zhang Sha Huang Xiaobing Fu | 2022 | Burns & Trauma2022，10，1： | 0 |
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