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| 1 | Characteristics of carbonyls and volatile organic compounds (VOCs) in residences in Beijing, China显示文摘不稳定的有机化合物(VOC ) 和羰基混合物在 50 个住处在室内并且在户外被测量在加热的北京(2011 年 12 月) 和非加热的季节(4 月 /5 月, 2012 ) 。为 VOC 的 SUMMA 罐和为羰基混合物的散开的刺绣花样在每个地点为 24 h 被部署,并且 94 混合物被确定。甲醛,丙酮和乙醛与是的室内的中部的集中在室内并且在户外是最丰富的羰基混合物 32.1, 21.7 和 15.3 g ?? | Hengyi DUAN Xiaotu LIU Meilin YAN Yatao WU Zhaorong LIU | 2016 | Frontiers of Environmental Science & Engineering2016，10，1： | 3 |
| 2 | Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer显示文摘 | Zhi Xu Haixia Zhu John M. Luk Dongmei Wu Dongying Gu Weida Gong Yongfei Tan Jianwei Zhou Jinhai Tang Zhengdong Zhang Meilin Wang Jinfei Chen | 2012 | Cancer2012，，22： | 2 |
| 3 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 4 | Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor显示文摘吗啡被要求在在外科手术前的时期期间支持肿瘤生长和转移的一个风险因素,和肿瘤房间的高 glycolysis 被证明加速肿瘤前进。在这研究,我们调查了是否 nalmefene,一个 opioid 受体禁止者,能通过影响细胞 glycolysis 禁止 CT26 结肠癌细胞生长。CCK8 和 transwell 迁居试金证明 nalmefene 以一种集中依赖者方式禁止了 CT26 房间生存能力和移植。细胞外的使发酸率和氧消费率证明 nalmefene 禁止了 CT26 房间的 glycolysis。而且,西方的污点分析和量的即时 PCR 表明 nalmefene 减少了与 glycolysis 有关的酶的表情。流动 cytometry 结果揭示了那细胞内部的钙(Ca 2+) 水平被 nalmefene 改变,西方的污点分析证明 nalmefene 减少了 calmodulin 表示和 calcium/calmodulin 依赖者蛋白质 kinases II (CaMK II ) phosphorylation,因此禁止 serine/threonine kinase (AKT ) 肝糖 synthase kinase-3 (GSK-3 ) 小径。而且, KN93 的效果, CaMK II 的一个禁止者,类似于 nalmefene,和 nalmefene 的反肿瘤效果的效果能被吗啡抵抗。在结论, nalmefene 的反肿瘤效果可以被禁止 opioid 受体和下面调整的 calmodulin 表示和 CaMK II phosphorylation 完成,因此禁止 AKT-GSK-3 小径和 CT26 房间的 glycolysis。 | Qichao Wu Xiangyuan Chen Jiaqiang Wang Pengfei Sun Meilin Weng Wankun Chen Zhirong Sun Minmin Zhu Changhong Miao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 5 | The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis显示文摘 | Danni Shi Shizhi Wang Dongying Gu Dongmei Wu Meilin Wang Haiyan Chu Na Tong Lan Ma Dongyan Zhong Zhengdong Zhang | 2012 | Journal of Cancer Research and Clinical Oncology2012，，8： | 2 |
| 6 | Spatial heterogeneity of bacterial community structure in the sediments of the Pearl River estuary显示文摘 | SUN Fulin WANG Youshao WU Meilin | 2011 | Biologia2011，66，： | 1 |
| 7 | Finite Element Analysis of Tire Thermomechanical Coupling Rolling Resistance显示文摘 | Wang Guolin Wu Jianjun Zhu Meilin | 2011 | Electric information and Control Engineering([CEICE)2011，，： | 1 |
| 8 | Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp. TZP29显示文摘 | Meilin Zhu Huquan Gao Chongming Wu Tianjiao Zhu Qian Che Qianqun Gu Peng Guo Dehai Li | 2015 | Bioorganic & Medicinal Chemistry Letters2015，，17： | 1 |
| 9 | A functional polymorphism in MIR 196 A 2 is associated with risk and prognosis of gastric cancer显示文摘 | Shizhi Wang Guoquan Tao Dongmei Wu Haixia Zhu Yan Gao Yongfei Tan Meilin Wang Weida Gong Yan Zhou Jianwei Zhou Zhengdong Zhang | 2013 | Mol Carcinog2013，，1： | 1 |
| 10 | Phase III, randomized, open‐label, first‐line study in Asia of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non‐small‐cell lung cancer: evaluation of patients recruited from mainland China显示文摘 | Yi‐Long WU Da‐Tong CHU Baohui HAN Xuyi LIU Li ZHANG Caicum ZHOU Meilin LIAO Tony MOK Haiyi JIANG Emma DUFFIELD Masahiro FUKUOKA | 2012 | Asia‐Pacific Journal of Clinical Oncology2012，，3： | 1 |
| 11 | Identifi- cation of anthropogenic effects and seasonality on water quality in Daya Bay, South China Sea显示文摘 | WU Meilin WANG Youshao SUN Cuici | 2009 | Journal of Envir- onmental Management2009，90，10： | 1 |
| 12 | Using chemometrics to evaluate anthropogenic effects in Daya Bay, China显示文摘 | WU MEILIN WANG YOUSHAO | 2007 | Estuar Coast Shelf S2007，72，4： | 1 |
| 13 | Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial显示文摘 | Yi-Long Wu Jin Soo Lee Sumitra Thongprasert Chong-Jen Yu Li Zhang Guia Ladrera Vichien Srimuninnimit Virote Sriuranpong Jennifer Sandoval-Tan Yunzhong Zhu Meilin Liao Caicun Zhou Hongming Pan Victor Lee Yuh-Min Chen Yan Sun Benjamin Margono Fatima Fuerte | 2013 | Lancet Oncology2013，，8： | 1 |
| 14 | Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial显示文摘 | Yi-Long Wu Jin Soo Lee Sumitra Thongprasert Chong-Jen Yu Li Zhang Guia Ladrera Vichien Srimuninnimit Virote Sriuranpong Jennifer Sandoval-Tan Yunzhong Zhu Meilin Liao Caicun Zhou Hongming Pan Victor Lee Yuh-Min Chen Yan Sun Benjamin Margono Fatima Fuerte | 2013 | Lancet Oncology2013，，8： | 1 |
| 15 | Statistical Prediction of 'Reasonable WorstCase' Crosstalk in Cable Bundles显示文摘 | WU Meilin BEETNER D G HUBING T H | 2009 | IEEE Transactions on Electromagnetic Compatibility2009，51，3： | 1 |
| 16 | Persistant expression of Pax3 in the neural crest causes cleft palate and defecture osteogenesis in mice显示文摘 | Meilin wu Jun Li Kurt | 2008 | The Journal of Clinical Investigation2008，118，6： | 1 |
| 17 | Exposure Response Relationship of Acute Effects of Air Pollution on Respiratory Diseases-China,2013−2018显示文摘Summary What is already known about this topic?Short-term exposure to air pollutants has been associated with chronic obstructive pulmonary disease(COPD)and asthma,which needs continuous observation.What is added by this report?This study uses the longest time series data so far from 2013 to 2018 and adds additional data analysis for ozone(O_(3))to existing studies. | Hongtao Niu Tao Yu Xuexin Li Hanna Wu Meilin Yan Ruirui Duan Ting Yang | 2021 | China CDC weekly2021，3，45： | 1 |
| 18 | Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial显示文摘 | Yi-Long Wu Jin Soo Lee Sumitra Thongprasert Chong-Jen Yu Li Zhang Guia Ladrera Vichien Srimuninnimit Virote Sriuranpong Jennifer Sandoval-Tan Yunzhong Zhu Meilin Liao Caicun Zhou Hongming Pan Victor Lee Yuh-Min Chen Yan Sun Benjamin Margono Fatima Fuerte | 2013 | Lancet Oncology2013，，8： | 1 |
| 19 | Spatial assessment of water quality using chemometrics in the Pearl River Estuary, China显示文摘 | Meilin WU Youshao WANG Junde DONG Fulin SUN Yutu WANG Yiguo HONG | 2017 | Frontiers of Earth Science2017，11，1： | 1 |
| 20 | Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population显示文摘 | Gang Zhang Dongying Gu Qinghong Zhao Haiyan Chu Zhi Xu Meilin Wang Cuiju Tang Dongmei Wu Na Tong Weida Gong Jianwei Zhou Yong Xu Zhengdong Zhang Jinfei Chen | 2014 | Biomedicine & Pharmacotherapy2014，，： | 1 |
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