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| 1 | Levomilnacipran and vortioxetine:Review of new pharmacotherapies for major depressive disorder显示文摘Major depressive disorder(MDD) is a common psychiatric disorder with an estimated lifetime prevalence rate in the range of 13% to 16% in the United States population. Patients with MDD often have symptoms such as depressed mood, loss of interest or pleasure in usual activities, changes in eating or sleeping patterns, fatigue, difficulty concentrating and thoughts of suicide. Although many pharmacotherapy treatment options are available for MDD, antidepressants can oftencause adverse effects that could affect adherence to the medication. Additionally, it is estimated that MDD is unremitting in 15% of patients and 35% can have recurrent episodes. Given the high rate of recurrence and the adverse effects associated with existing medications, new treatment options for depression are needed. Both levomilnacipran and vortioxetine are new antidepressants that were approved by the food and drug administration in 2013 for the treatment of MDD in adults. Levomilnacipran is a serotonin norepinephrine reuptake inhibitor that was effective in several short term studies and sustained efficacy and tolerability was demonstrated in a 48-wk extension study. Vortioxetine is a multi-modal antidepressant and it is thought to work via inhibition of the serotonin(5-HT) transporter, 5-HT3 A, 5-HT7 and 5-HT1 D antagonist, a 5-HT1 B partial agonist, and a 5-HT1 A agonist. Vortioxetine was effective in the treatment of MDD in both short-term trials as well as in the prevention of relapse in a 24-36 wk trial. Sustained efficacy and tolerability was demonstrated in several long-term open-label trials. Further studies comparing levomilnacipran and vortioxetine to other currently available antidepressants are needed to establish its place in therapy. | Mei T Liu Megan E Maroney Evelyn R Hermes-DeSantis | 2015 | World Journal of Pharmacology2015，4，1： | 3 |
| 2 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 3 | Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species(ROS)/Akt signaling显示文摘 | Wan J Liu T Mei L | 2013 | British J Can2013，109，2： | 1 |
| 4 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | Liu E Yan C Mei X He W Bing SH Ding L Liu Q Liu S Fan T | 2010 | Geoderrna2010，158，： | 1 |
| 5 | The Mg-ehelatase H subunit of Arabidopsis antagonizes a group of WRKY transcription repressors to relieve ABA-responsive genes of inhibition显示文摘 | SHANG Y YAN L LIU Z Q CAO Z MEI C XIN Q WU F Q WANG X F DU S Y JIANG T ZHANG X F ZHAO R SUN H L LIU R YU Y T ZHANG D P | 2010 | Plant Cell2010，22，： | 1 |
| 6 | Supervised image seg mentation based on tree-structured MRF model in wavelet do main 显示文摘 | Liu G Y Qin Q Q Mei T C | 2009 | IEEE Geoscience and Remote Sensing Letters2009，6，4： | 1 |
| 7 | On the maximal inequality for martingales involving two functions显示文摘 | Mei T Liu P D | 2002 | Proceedings of AMS2002，130，： | 1 |
| 8 | Optimal design of a 4-DOF SCARA type parallel robot using dynamic performance indices and angular constraints 显示文摘 | LIU S T HUANG T MEI J P | 2012 | ASME Journal of Mechanisms and Robotics2012，4，3： | 1 |
| 9 | Proteomics analysis of H-RAS-mediated oncogenic transformation in a genetically defined human ovarian cancer model显示文摘 | Mei F Liu J | 2005 | Oncogene2005，24，40： | 1 |
| 10 | Quadratic head loss and scattering of long waves显示文摘 | Mei C C Liu P L F Ippen A T | 1974 | Journal of Waterway Harbour and Coastal Engineering Division ASCE1974，100，3： | 1 |
| 11 | The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes 显示文摘 | Liu S Liu Y Yang X Tong C Edwards D Parkin I A P Zhao M Ma J Yu J Huang S Wang X Wang J Lu K Fang Z Bancroft I Yang T J Hu Q Wang X Yue Z Li H Yang L Wu J Zhou Q Wang W King G J Chris Pires J Lu C Wu Z Sampath P Wang Z Guo H Pan S Yang L Min J Zhang D Jin D Li W Belcram H Tu J Guan M Qi C Du D Li J Jiang L Batley J Sharpe A G Park B S Ruperao P Cheng F Espinosa Waminal N Huang Y Dong C Wang L Li J Hu Z Zhuang M Huang Y Huang J Shi J Mei D Liu J Lee T Wang J Jin H Li Z Li X Zhang J Xiao L Zhou Y Liu Z Liu X Qin R Tang X Liu W Wang Y Zhang Y Lee J Kim H H Denoeud F Xu X Liang X Hua W Wang X Wang J Chalhoub B Paterson A H | 2014 | Nature Communications2014，5，： | 1 |
| 12 | Supervised image segmentation based on tree-structured MRF model in wavelet domain 显示文摘 | LIU G Y QIN Q Q MEI T C | 2009 | IEEE Geoscience and Remote Sensing Letters2009，6，4： | 1 |
| 13 | The Effect of Thermal Treatment on the Electrical Properties of Titanium Nitride Thin Films by Filtered Are Plasma Method 显示文摘 | Wang J M Liu W G Mei T | 2004 | Ceramics International2004，30，7： | 1 |
| 14 | Classification of lychee cultivars with RAPD analysis显示文摘 | LIU C M MEI M T | 2005 | Acta Horticulturae2005，665，： | 1 |
| 15 | Quadratic head loss and scattering of long waves显示文摘 | Mei C C Liu P L F Ippen A T | 1974 | Journal of Waterway Harbour and Coastal Engineering Division1974，99，： | 1 |
| 16 | Construction of a Lychee Genetic LinkageMap Based on RAPD Markers显示文摘 | Liu C M Mei M T | 2003 | Acta Horticulturae2003，，625： | 1 |
| 17 | Optimal Design of a 4-DOF SCARA Type Parallel Robot Using Dynamic Performance Indices and Angular Constraints 显示文摘 | Liu S T Huang T Mei J P etc | 2012 | ASME Journal of Mechanisms and Robotics2012，，4： | 1 |
| 18 | Candidate defense genes as predictors of quantitative blast resistance in rice显示文摘 | Liu B Zhang S.H Zhu X.Y Yang Q.Y Wu S.Z Mei M.T Mauleon R Leach J Mew T and Leung H | | 0，，10： | 1 |
| 19 | Ultra-compliant liquid metal electrodes with in-plane self-healing capability for dielectric elastomer actuators 显示文摘 | Liu Y Gao M Mei S F Han Y T Liu J | 2013 | Applied Physics Letters2013，102，06： | 1 |
| 20 | Bimaterial interfacial crack growthas a function of mode-mixity 显示文摘 | Liu S Mei Y H Wu T Y | 1995 | Trans Compon Packg Manuf Techno part A1995，18，3： | 1 |
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