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| 1 | Protein misfolding in neurodegenerative diseases:implications and strategies显示文摘A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy pathways.Other therapies,like mTOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic network.However,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies. | Patrick Sweeney Hyunsun Park Marc Baumann John Dunlop Judith Frydman Ron Kopito Alexander McCampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert Hodgson | 2017 | Translational Neurodegeneration2017，6，1： | 4 |
| 2 | Overexpression of the insulin - like growth factor I receptor and activation of the AKT pathway in hyperplastic endometfium 显示文摘 | McCampbell AS Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 3 | Diabetes and bums :retrospective cohort study 显示文摘 | McCampbell B Wasif N Rabbitts A | 2002 | J Burn Care Rehabil2002，23，3： | 1 |
| 4 | Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium显示文摘 | McCampbell AS Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 5 | Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium 显示文摘 | McCampbell AS Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 6 | Overexpres- sion of the insulin-like growth hctor I receptor and activation of the AKT pathway in hyperplastic endometrium显示文摘 | McCampbell AS Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 7 | New tides: using zebrafish to study renal regeneration显示文摘 | Kristen K. McCampbell Rebecca A. Wingert | 2013 | Translational Research2013，，： | 1 |
| 8 | Knowledge Management: The New Challenge for the 21st Century显示文摘 | McCampbell A S | 1999 | Journal of Knowledge Management1999，3，3： | 1 |
| 9 | Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastie endometrium显示文摘 | MCCAMPBELL AS BROADDUS RR LOOSE D S | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 10 | CREB-binding protein sequestration by expanded polyglutamine 显示文摘 | McCampbell A Taylor JP Taye AA | 2000 | Hum Mol Genet2000，9，： | 1 |
| 11 | Biolateral injections of beta A(25~35)+IBO into the himppocampus disrups acquisition of spatial learning in the rat 显示文摘 | Dornan WA Kang DE McCampbell A | 1993 | Neuroreport1993，5，2： | 1 |
| 12 | Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration显示文摘 | Kristen K. McCampbell Kristin N. Springer Rebecca A. Wingert Takashi Yokoo | 2015 | Stem Cells International2015，，： | 1 |
| 13 | Overexpression of the insulin-like growth factor I receptor and activation of the Akt pathway in hyperplastic endometrium显示文摘 | McCampbell AS Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 14 | Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometfium 显示文摘 | Adrienne S McCampbell Russell R Broaddus | 2006 | Clin Cancer Res2006，12，： | 1 |
| 15 | Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium 显示文摘 | Mccampbell AS Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 16 | Overexpression of the insulin-like growth factor Ⅰ receptor and activation of the AKT pathway in hyperplastic endometrium显示文摘 | McCampbell AS Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 17 | Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium显示文摘 | Broaddus RR Loose DS | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 18 | Sex hormone regulation of survivin gene expression 显示文摘 | Nabilsi NH Broaddus RR McCampbell AS | 2010 | J Endocrinol2010，207，2： | 1 |
| 19 | CREB-binding protein sequestration by expanded potyglutamine 显示文摘 | McCampbell A Taylor JP Taye AA | 2000 | Human molecular genetics2000，9，14： | 1 |
| 20 | Loss of inhibitory insulin receptor substrate-I phosphorylation is an early event in mammalian target of rapamyein-dependent endometrial hypevplasia and carcinoma显示文摘 | McCampbell AS HmTis HA Crabtree JS | 2010 | Cancer Prey Res (Phila)2010，3，3： | 1 |
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