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| 1 | Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants显示文摘BACKGROUND:After pancreaticoduodenectomy,the incidence of postoperative pancreatic fistula remains high,especially in patients with 'soft' pancreatic tissue remnants.No 'gold standard' surgical technique for pancreaticoenteric anastomosis has been established.This study aimed to compare the postoperative morbidity and mortality of pancreaticogastrostomy and pancreaticojejunostomy for 'soft' pancreatic tissue remnants using modified mattress sutures.METHODS:Seventy-five patients who had undergone pancreaticogastrostomy and 75 who had undergone pancreaticojejunostomy after pancreaticoduodenectomy between 2002 and 2008 were retrospectively compared using matched-pair analysis.A modified mattress suture technique was used for the pancreaticoenteric anastomosis.Patients with an underlying 'hard' pancreatic tissue remnant,as in chronic pancreatitis,were excluded.Both groups were homogeneous for age,gender,and underlying disease.Postoperative morbidity,mortality,and preoperative and operative data were analyzed.RESULTS:There were no significant differences between the groups for the incidence of postoperative pancreatic fistula (10.7% in both).Postoperative morbidity and mortality,median operation time,median length of hospital stay,intraoperative blood loss,and the amount of intraoperatively transfused erythrocyte concentrates also did not significantly differ between the groups.Patient age >65 years (P=0.017),operation time >350minutes (P=0.001),and intraoperative transfusion of erythrocyte concentrates (P=0.038) were identified as risk factors for postoperative morbidity.CONCLUSIONS:Our results showed no significant differences between the groups in the pancreaticogastrostomy and pancreaticojejunostomy anastomosis techniques using mattress sutures for 'soft' pancreatic tissue remnants.In our experience,the mattress sutures are safe and simple to use,and pancreaticogastrostomy in particular is feasible and easy to learn,with good endoscopic accessibility to the anastomosis region.However,the location of the anastomosis and the surgical technique need to be individually evaluated to further reduce the incidence of postoperative pancreatic fistula. | Fritz Klein Marcus Bahra Matthias Glanemann Wladimir Faber Peter Warnick Andreas Andreou Safak Gül Dietmar Jacob | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 9 |
| 2 | miR-21 and its target gene CCL20 are both highly overexpressed in themicroenvironment of colorectal tumors: Significance of their regulation显示文摘 | Benjamin Vicinus Claudia Rubie Nathalie Stegmaier Vilma Frick Kathrin K?lsch Anne Kauffels Pirus Ghadjar Mathias Wagner Matthias Glanemann | 2013 | Oncology Reports2013，，3： | 2 |
| 3 | Giant cell tumor of the distal common bile duct: report of a rare, benign entity that may mimic malignant biliary obstruction显示文摘 | Theodoros Kolokotronis Matthias Glanemann Mathias Wagner Rainer M. Bohle Frank Grünhage | 2014 | International Journal of Colorectal Disease2014，，3： | 1 |
| 4 | SIGNIFICANCE OF A T-LYMPHOCYTOTOXIC CROSSMATCH IN LIVER AND COMBINED LIVER-KIDNEY TRANSPLANTATION显示文摘 | Ulf P. Neumann Martina Lang Anja Moldenhauer Jan M. Langrehr Matthias Glanemann Andreas Kahl Ullrich Frei Wolf O. Bechstein Peter Neuhaus | 2001 | Transplantation2001，，8： | 1 |
| 5 | Distal Pancreatectomy With En Bloc Resection of the Celiac Trunk for Extended Pancreatic Tumor Disease: An Interdisciplinary Approach显示文摘 | Timm Denecke Andreas Andreou Petr Podrabsky Christian Grieser Peter Warnick Marcus Bahra Fritz Klein Bernd Hamm Peter Neuhaus Matthias Glanemann | 2011 | CardioVascular and Interventional Radiology2011，，： | 1 |
| 6 | Postoperative Complications Deteriorate Long-Term Outcome in Pancreatic Cancer Patients显示文摘 | Carsten Kamphues Roberta Bova Dorothee Schricke Michael Hippler-Benscheidt Frederick Klauschen Albrecht Stenzinger Daniel Seehofer Matthias Glanemann Peter Neuhaus Marcus Bahra | 2012 | Annals of Surgical Oncology2012，，： | 1 |
| 7 | Incidence and indications for reintubation during postoperative care following orthotopic liver transplantation显示文摘 | Matthias Glanemann Udo Kaisers Jan M Langrehr Rolando Schenk Barbara J Stange Andrea R Müller Wolf-Otto Bechstein Konrad Falke Peter Neuhaus | 2001 | Journal of Clinical Anesthesia2001，，5： | 1 |
| 8 | Ischemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state显示文摘 | Matthias Glanemann Brigitte Vollmar Andreas K Nussler Thilo Schaefer Peter Neuhaus Michael D Menger | 2002 | Journal of Hepatology2002，，1： | 1 |
| 9 | Ischemic Preconditioning Impairs Liver Regeneration in Extended Reduced-Size Livers显示文摘 | Christian Eipel Matthias Glanemann Andreas K. Nuessler Michael D. Menger Peter Neuhaus Brigitte Vollmar | 2005 | Annals of Surgery2005，，3： | 1 |
| 10 | Hepatic artery thrombosis after adult liver transplantation显示文摘 | Barbara J. Stange Matthias Glanemann Natascha C. Nuessler Utz Settmacher Thomas Steinmüller Peter Neuhaus | 2003 | Liver Transplantation2003，，6： | 1 |
| 11 | Transplantation of Monocyte-Derived Hepatocyte-Like Cells (NeoHeps) Improves Survival in a Model of Acute Liver Failure显示文摘 | Matthias Glanemann Gereon Gaebelein Natascha Nussler Liping Hao Zienab Kronbach Baomin Shi Peter Neuhaus Andreas K. Nussler | 2009 | Annals of Surgery2009，，1： | 1 |
| 12 | Prolyl Hydroxylase Domain 2 Protein Is a Strong Prognostic Marker in Human Gastric Cancer显示文摘 | Kamphues Carsten Wittschieber Daniel Klauschen Frederick Kasajima Atsuko Dietel Manfred Schmidt Sven-christian Glanemann Matthias Bahra Marcus Neuhaus Peter Weichert Wilko Stenzinger Albrecht | 2012 | Pathobiology2012，，： | 1 |
| 13 | Incidence and indications for reintubation during postoperative care following orthotopic liver transplantation显示文摘 | Matthias Glanemann Udo Kaisers Jan M Langrehr Rolando Schenk Barbara J Stange Andrea R Müller Wolf-Otto Bechstein Konrad Falke Peter Neuhaus | 2001 | Journal of Clinical Anesthesia2001，，5： | 1 |
| 14 | Ischemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state显示文摘 | Matthias Glanemann Brigitte Vollmar Andreas K Nussler Thilo Schaefer Peter Neuhaus Michael D Menger | 2002 | Journal of Hepatology2002，，1： | 1 |
| 15 | Prospective Randomized Comparison between a New Mattress Technique and Cattell (duct-to-mucosa) Pancreaticojejunostomy for Pancreatic Resection显示文摘 | Jan M. Langrehr M.D. Marcus Bahra M.D. Dietmar Jacob M.D. Matthias Glanemann M.D. Peter Neuhaus M.D | 2005 | World Journal of Surgery2005，，9： | 1 |
| 16 | Safety of Pancreatic Surgery in Patients with Simultaneous Liver Cirrhosis: A Single Center Experience显示文摘 | Peter Warnick Ivo Mai Fritz Klein Andreas Andreou Marcus Bahra Peter Neuhaus Matthias Glanemann | 2011 | Pancreatology2011，，1： | 1 |
| 17 | Hepatotropic growth factors protect hepatocytes during inflammation by upregulation of antioxidative systems显示文摘AIM:To investigate effects of hepatotropic growth factors on radical production in rat hepatocytes during sepsis.METHODS:Rat hepatocytes,isolated by collagenase perfusion,were incubated with a lipopolysaccharide(LPS)-containing cytokine mixture of interleukin-1β,tumor necrosis factor-α and interferon-γ to simulate sepsis and either co-incubated or pre-incubated with hepatotropic growth factors,e.g.hepatocyte growth factor,epidermal growth factor and/or transforming growth factor-α.Cells were analyzed for glutathione levels.Culture supernatants were assayed for produc-tion of reactive oxygen intermediates(ROIs) as well as NO2-,NO3-and S-nitrosothiols.To determine cellular damage,release of aspartate aminotransferase(AST) into the culture medium was analyzed.Activation of nuclear factor(NF)-κB was measured by electrophoretic mobility shift assay.RESULTS:Rat hepatocytes treated with the LPS-containing cytokine mixture showed a significant increase in ROI and nitrogen oxide intermediate formation.AST leakage was not significantly increased in cells treated with the LPS-containing cytokine mixture,independent of growth-factor co-stimulation.However,pretreatment with growth factors significantly reduced AST leakage and ROI formation while increasing cellular glutathione.Application of growth factors did not result in increased NF-κB activation.Pretreatment with growth factors further increased formation of NO2-,NO3-and S-nitrosothiols in hepatocytes stimulated with LPS-containing cytokine mixture.Thus,we propose that,together with an increase in glutathione increased NO2-,NO3-formation might shift their metabolism towards non-toxic products.CONCLUSION:Our data suggest that hepatotropic growth factors positively influence sepsis-induced hepatocellular injury by reducing cytotoxic ROI formation via induction of the cellular protective antioxidative systems. | Matthias Glanemann Daniel Knobeloch Sabrina Ehnert Mihaela Culmes Claudine Seeliger Daniel Seehofer Andreas K Nussler | 2011 | World Journal of Gastroenterology2011，17，17： | 0 |
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