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| 1 | Circulating extracellular RNAs,myocardial remodeling,and heart failure in patients with acute coronary syndrome显示文摘Background:Given high on-treatment mortality in heart failure(HF),identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues.Circulating extracellular RNAs(ex-RNAs)regulate important biological processes and are emerging as biomarkers of disease,but less is known about their role in the acute setting,particularly in the setting of HF.Methods:We examined the ex-RNA profiles of 296 acute coronary syndrome(ACS)survivors enrolled in the Transitions,Risks,and Actions in Coronary Events Center for Outcomes Research and Education Cohort.We measured 374 ex-RNAs selected a priori,based on previous findings from a large population study.We employed a two-step,mechanism-driven approach to identify ex-RNAs associated with echocardiographic phenotypes(left ventricular[LV]ejection fraction,LV mass,LV end-diastolic volume,left atrial[LA]dimension,and LA volume index)then tested relations of these ex-RNAs with prevalent HF(N=31,10.5%).We performed further bioinformatics analysis of microRNA(miRNAs)predicted targets’genes ontology categories and molecular pathways.Results:We identified 44 ex-RNAs associated with at least one echocardiographic phenotype associated with HF.Of these 44 exRNAs,miR-29-3p,miR-584-5p,and miR-1247-5p were also associated with prevalent HF.The three microRNAs were implicated in the regulation p53 and transforming growth factor-βsignaling pathways and predicted to be involved in cardiac fibrosis and cell death;miRNA predicted targets were enriched in gene ontology categories including several involving the extracellular matrix and cellular differentiation.Conclusions:Among ACS survivors,we observed that miR-29-3p,miR-584-5p,and miR-1247-5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF.Relevance for Patients:miR-29c-3p,miR-584-5p,and miR-1247-5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. | Khanh-Van Tran Kahraman Tanriverdi Gerard P.Aurigemma Darleen Lessard Mayank Sardana Matthew Parker Amir Shaikh Matthew Gottbrecht Zachary Milstone Selim Tanriverdi Olga Vitseva John F.Keaney Catarina I.Kiefe David D.McManus Jane E.Freedman | 2019 | Journal of Clinical & Translational Research2019，5，1： | 7 |
| 2 | A prescription for clinical immunology: the pills are available and ready for testing. A review显示文摘 | William Parker Sarah E. Perkins Matthew Harker Michael P. Muehlenbein | 2012 | Current Medical Research & Opinion2012，，7： | 1 |
| 3 | Metabolism and disposition of diethylene glycol in rat and dog 显示文摘 | Mathews JM Parker MK Matthews HB | 1991 | Drug Metab Dispos1991，19，6： | 1 |
| 4 | Anterior Cruciate Ligament Revision Reconstruction – Two-Year Results From the MOON Cohort显示文摘 | Rick Wright Warren Dunn Annunziato Amendola Jack Andrish David Flanigan Morgan Jones Christopher Kaeding Robert Marx Matthew Matava Eric McCarty Richard Parker Armando Vidal Michelle Wolcott Brian Wolf Kurt Spindler | 2007 | J Knee Surg2007，，04： | 1 |
| 5 | Investigating employee perceptions of a framework of safety culture maturity显示文摘 | Matthew Lawrie Dianne Parker and Patrick Hudson | 2006 | Safety Science2006，14，3： | 1 |
| 6 | Effect of surface catalysis on measured heat transfer in expansion tun nel facility显示文摘 | Matthew M Eric M Ronald Parker | | 0，，02： | 1 |
| 7 | Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer显示文摘 | Sonia Ancoli-Israel Lianqi Liu Matthew R. Marler Barbara A. Parker Vicky Jones Georgia Robins Sadler Joel Dimsdale Mairav Cohen-Zion Lavinia Fiorentino | 2006 | Supportive Care in Cancer2006，，3： | 1 |
| 8 | The Initiation and Evolution of Multiple Modes of Convection within a Meso-Alpha-Scale Region显示文摘 | French Adam J Parker Matthew D | 2008 | Weather and Forecasting2008，，6： | 1 |
| 9 | Vertebroplasty and kyphoplasty for the treatment of vertebral compression fractures: an evidenced-based review of the literature显示文摘 | Matthew J. McGirt Scott L. Parker Jean-Paul Wolinsky Timothy F. Witham Ali Bydon Ziya L. Gokaslan | 2009 | The Spine Journal2009，，： | 1 |
| 10 | Superior Mesenteric Artery Margin of Posttherapy Pancreaticoduodenectomy and Prognosis in Patients With Pancreatic Ductal Adenocarcinoma显示文摘 | Li Liu Matthew H. Katz Sun M. Lee Laurice K. Fischer Laura Prakash Nathan Parker Hua Wang Gauri R. Varadhachary Robert A. Wolff Jeffrey E. Lee Peter W. Pisters Anirban Maitra Jason B. Fleming Jeannelyn Estrella Asif Rashid Huamin Wang | 2015 | The American Journal of Surgical Pathology2015，，10： | 1 |
| 11 | Health-related fitness in sport education andmulti-activity teaching显示文摘 | Mitchum B Parker Matthew Curtner-Smith | 2005 | Physical Educatioin and SportPedagogy2005，10，1： | 1 |
| 12 | Bias and discriminability during emotional signal detection in melancholic depression显示文摘 | Matthew Hyett Gordon Parker Michael Breakspear | 2014 | BMC Psychiatry2014，14，： | 1 |
| 13 | Control of cellular motility by neuropilin-mediated physical interactions显示文摘 | Xiaobo Li Matthew W. Parker Craig W. Vander Kooi | 2014 | Biomolecular Concepts2014，，： | 1 |
| 14 | Investigating employee perceptions of a framework of safety culture maturity显示文摘 | Matthew Lawrie Dianne Parker Patrick Hudson | 2006 | Safety Scionce2006，44，3： | 1 |
| 15 | A framework for understanding the development of organisational safety culture显示文摘 | Dianne Parker Matthew Lawrie Patrick Hudson | 2006 | Safety Science2006，44，6： | 1 |
| 16 | 35. Vertebroplasty and Kyphoplasty for the Treatment of Vertebral Compression Fractures: An Evidenced Based Review of the Literature显示文摘 | Matthew McGirt Scott Parker Jean-Paul Wolinsky Timothy Witham Ali Bydon Ziya Gokaslan | 2009 | The Spine Journal2009，，10： | 1 |
| 17 | A framework for understanding the development of organisational safety culture显示文摘 | DIANNE PARKER MATTHEW LAWRIE PATRICK HUDSON | 2006 | Safety Science2006，44，6： | 1 |
| 18 | Use of a purified outer membrane protein (porin) preparation of Pseudornonas aeruginosa as a protective vaccine in mice显示文摘 | Gilleland HE Parker MG Matthews JM | 1984 | Infect Immun1984，44，1： | 1 |
| 19 | Use of a purified outer membrane protein F (Porin) preparation of pseudomonas aeruginosa as a protective vaccine in mice 显示文摘 | Gilleland HE Parker MG Matthews JM | 1984 | Infect Immun1984，44，1： | 1 |
| 20 | Mental Health Disorders and Solid-Organ Transplant Recipients显示文摘 | Chris Corbett Matthew J. Armstrong Richard Parker Kerry Webb James M. Neuberger | 2013 | Transplantation Journal2013，，7： | 1 |
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