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4篇 您的检索式：作者名="Matthew J Hilton"

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		题名	作者	年代	出处	被引量
	1	Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.	Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton	2015	Bone Research2015，3，3：	8
	2	EXTI regulates chondroeyte proliferation and differentiation during endochondral bone development 显示文摘	Matthew J Hilton Laura Gutierrez Daniel A Martinez	2005	Bone2005，36，：	1
	3	NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-[Kappa]B显示文摘	Zhang Hengwei Hilton Matthew J Anolik Jennifer H Welle Stephen L Zhao Chen Yao Zhenqiang Li Xing Wang Zhiyu Boyce Brendan F Xing Lianping	2014	Journal of Clinical Investigation2014，，：	1
	4	Bioconversion of cinnamie acid to acetophenone by a pseudomonad: microbial production of a natural flavor compound 显示文摘	Matthew D Hilton Wendy J Cain	1990	Applied and Environmental Microbiology1990，，：	1

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