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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Synthesis of a CrCoAPO-5(AFI) molecular sieve and its activity in cyclohexane oxidation in the liquid phase显示文摘 | Masters A F Beattie James K Roa Adriana L | 2001 | Catal Lett2001，75，34： | 1 |
| 3 | Synthesis of a CrCo-APO-5(AFI) molecular sieve and its activi- ty in cyelohexane oxidation in the liquid phase显示文摘 | MASTERS A F BEATTIE J K ROA A L | 2001 | Catal Lett2001，75，34： | 1 |
| 4 | Metabolic syndrome in psychiatrically hospitalized patients treated with antipsychotics and other psychotropics 显示文摘 | Centorrino F Masters GA Talamo A | 2012 | Hum Psychopharmacol2012，27，： | 1 |
| 5 | Persistent cough in children and the overuse of medications显示文摘 | Thomson F Masters I B Chang A B | 2002 | Journal of Paediatrics and Child Health2002，38，57： | 1 |
| 6 | Muhivariate stochastic simulation of wind pressure over low-rise structures through linear model interpolation 显示文摘 | Masters F Gurley K Kopp G A | 2010 | Journal of Wind Engineering and Industrial Aerodynamics2010，98，45： | 1 |
| 7 | Finite-frequency tomography reveals a variety of plumes in the mantle显示文摘 | Montelli R Nolet G Dahlen F A Masters G Engdahl E R Hung Shu-huei | 2004 | Science2004，303，： | 1 |
| 8 | Hurricane wind power spectra, cospectra, and integral length scales 显示文摘 | Yu B Gan Chowdhury A Masters F J | 2008 | Boundary-Layer Meteorology2008，129，3： | 1 |
| 9 | Synthesis of a CrCoAPO-5 (AFI) molecular sieve and its activity in cyclohexane oxidation in the liquid phase显示文摘 | MASTERS A F BEATTIE J K ROA A L | 2001 | Catalysis Letters2001，75，34： | 1 |
| 10 | Cheddar cheese from retentate-supplemented whole milk显示文摘 | Kosikowski F V Masters A R Mistry V V | 1985 | J Dairy Sci1985，68，3： | 1 |
| 11 | Catalyst compartmentalization in dynamic kinetic resolutions显示文摘 | Fois A F Yap A Masters A F | | 0，，1： | 1 |
| 12 | Children’s consensual knowledge about the experiential determinants of emotion显示文摘 | Barden R C Zeiko F A Duncan S W Masters J C | 1980 | Journal of Personality and Social Psychology1980，39，： | 1 |
| 13 | Monte Carlo simulation and self-consistent field theory for a single chain on a diamond lattice显示文摘 | YUAN X F MASTERS A J J | 1991 | Chem Phys1991，94，10： | 1 |
| 14 | Wavelet analyses of turbulence in the hurricane surface layer during landfalls显示文摘 | Zhu P Zhang J A Masters F J | 2010 | Journal of the At- mospheric Sciences2010，67，12： | 1 |
| 15 | Surface wind measurements in three gulf coast hurricanes of 2005 显示文摘 | Masters F J Tieleman H W Balderrama J A | 2010 | Journal of Wind Engineering and Industrial Aerodynamics2010，98，1011： | 1 |
| 16 | Hurricane wind power spectra, cospectra, and integral length scales显示文摘 | Yu B Chowdhury A G Masters F J | 2008 | Boundary- Layer Meteorol2008，，： | 1 |
| 17 | Hurricane wind power spectra, cospectra, and integral length scales 显示文摘 | YU B GAN CHOWDHURY A MASTERS F | 2008 | Boundary-Layer Meteorology2008，129，3： | 1 |
| 18 | Hurricane wind power spectra, cospectra, and integral length scales 显示文摘 | Yu B Gan Chowdhury A Masters F | 2008 | Boundary- Layer Meteorology2008，129，3： | 1 |
| 19 | Exploring the myth of nascent hydrogen and its implications for biomass conversions 显示文摘 | FABOS V YUEN A K L MASTERS A F | 2012 | Chemistry : An Asian Jourrta12012，7，11： | 1 |
| 20 | Hurricane wind power spectra,cospectra,and integral length scales显示文摘 | YU B CHOWDHURY A G MASTERS F J | | 0，，： | 1 |
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