6篇
您的检索式：作者名="Massimo Pancione"
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| 1 | emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer显示文摘Multiple lines of evidence indicate that Wnt/β-catenin signaling plays a fundamental role in colorectal cancer(CRC)initiation and progression.Recent genome-wide data have confirmed that in CRC this pathway is one of the most frequently modified by genetic or epigenetic alterations affecting almost 90%of Wnt/β-catenin gene members.A major challenge is thus learning how the corrupted coordination of this pathway is tied to other signalings to enhance cell growth.Peroxisome proliferator activated receptorγ(PPARγ)is emerging as a growth-limiting and differentiation-promoting factor.In tumorigenesis it exerts a tumor suppressor role and is potentially linked with the Wnt/β-catenin pathway.Based on these results,the identification of new selective PPARγmodulators with inhibitory effects on the Wnt/β-catenin pathway is becoming an interesting perspective.Should,in fact,these molecules display such properties,new research avenues would be opened aimed at developing new molecular targeted drugs.Herein,we review the basic principles and present new hypotheses underlying the crosstalk between Wnt/β-catenin and PPARγsignaling.Furthermore,we discuss the advances in our understanding as to how their altered regulation can culminate in colon cancer and the efforts aimed at designing novel PPARγagonists endowed with Wnt/β-catenin inhibitory effects to be used as therapeutic and/or preventive agents. | Lina Sabatino Massimo Pancione Carolina Votino Tommaso Colangelo Angelo Lupo Ettore Novellino Antonio Lavecchia Vittorio Colantuoni | 2014 | World Journal of Gastroenterology2014，20，23： | 8 |
| 2 | Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions显示文摘Pancreatic cancer(PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addressed as a potential therapeutic target. Nano albumin bound(Nab)-paclitaxel is an innovative molecule depleting tumor stroma, through interaction between albumin and secreted protein acidic and rich in cysteine. Addition of nab-paclitaxel to gemcitabine has showed activity and efficacy in metastatic PDAC first-line treatment improving survival and overall response rate vs gemcitabine alone in the MPACT phase Ⅲ study. This combination represents one of the standards of care in advanced PDAC therapy and is suitable to a broader spectrum of patients compared to other schedules. Nab-paclitaxel is under investigation as a backbone of chemotherapy in novel combinations with target agents or immunotherapy in locally advanced or metastatic PDAC. In this article, we provide an updated and critical overview about the role of nab-paclitaxel in PDAC treatment based on the latest advances in preclinical and clinical research. Furthermore, we focus on the use of nab-paclitaxel within the context of metastatic PDAC treatment landscape and we discuss about future implications in the light of current clinical ongoing trials. | Guido Giordano Massimo Pancione Nunzio Olivieri Pietro Parcesepe Marianna Velocci Tania Di Raimo Luigi Coppola Giuseppe Toffoli Mario Rosario D’Andrea | 2017 | World Journal of Gastroenterology2017，23，32： | 7 |
| 3 | Genetic and Epigenetic Events Generate Multiple Pathways inColorectal Cancer Progression显示文摘 | Massimo Pancione Andrea Remo Vittorio Colantuoni Ka F. To | 2012 | Pathology Research International2012，，： | 3 |
| 4 | MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer显示文摘 | Tommaso Colangelo Alessandra Fucci Carolina Votino Lina Sabatino Massimo Pancione Carmelo Laudanna Monica Binaschi Mario Bigioni Carlo Alberto Maggi Domenico Parente Nicola Forte Vittorio Colantuoni | 2013 | Neoplasia2013，，： | 1 |
| 5 | Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer显示文摘 | Anna Panza Carolina Votino Annamaria Gentile Maria Rosaria Valvano Tommaso Colangelo Massimo Pancione Giuseppe Merla Angelo Andriulli Lina Sabatino Manlio Vinciguerra Gianluigi Mazzoccoli Vittorio Colantuoni Ada Piepoli | 2014 | BBA - Molecular Cell Research2014，，： | 1 |
| 6 | PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis显示文摘 | Lina Sabatino Alessandra Fucci Massimo Pancione Vittorio Colantuoni Bart Staels | 2012 | PPAR Research2012，，： | 1 |
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