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| 1 | Enhancement patterns of pancreatic adenocarcinoma on conventional dynamic multi-detector row CT:Correlation with angiogenesis and fibrosis显示文摘AIM:To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma.METHODS: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, 'tumor-aorta enhancement ratio', which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis.RESULTS: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P=0.047, P=0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P=0.003, P=0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P=0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase.CONCLUSION: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis. | Yuki Hattori Toshifumi Gabata Osamu Matsui Kentaro Mochizuki Hirohisa Kitagawa Masato Kayahara Tetsuo Ohta Yasuni Nakanuma | 2009 | World Journal of Gastroenterology2009，15，25： | 15 |
| 2 | Intraductal papillary neoplasm of the bile duct accompanying biliary mixed adenoneuroendocrine carcinoma显示文摘We present the first case of an intraductal papillary neoplasm of the bile duct(IPNB) accompanying a mixed adenoneuroendocrine carcinoma(MANEC).A 74-yearold woman presented with fever of unknown cause.Laboratory data revealed jaundice and liver injury.Contrast-enhanced computed tomography revealed a 20 mm polypoid tumor in the dilated distal bile duct,which exhibited early enhancement and papillary growth.Upper gastrointestinal endoscopy revealed mucus production from the papilla of Vater,characterized by its protruding and dilated orifice.Endoscopic ultrasonography visualized the polypoid tumor in the distal bile duct,but no invasive region was suggested by diagnostic imaging.Therefore,the initial diagnosis was IPNB.After endoscopic nasobiliary drainage,a pylorus-preserving pancreaticoduodenectomy was performed.Pathological examination of the resected bile duct revealed papillary proliferation of biliary-type cells with nuclear atypia,indicating pancreaticobiliary-type IPNB.In addition,solid portions comprised of tumor cells with characteristic salt-and-pepper nuclei were evident.Immunohistochemistry revealed expression of the neuroendocrine marker synaptophysin in this solid component,diagnosing it as a neuroendocrine tumor(NET).Furthermore,the MIB-1 proliferation index of NET was higher than that of IPNB,and microinvasion of the NET component was found,indicating neuroendocrine carcinoma(NET G3).This unique case of MANEC,comprising IPNB and NET,provides insight into the pathogenesis of biliary NET. | Ichiro Onishi Hirohisa Kitagawa Kenichi Harada Syogo Maruzen Seisyo Sakai Isamu Makino Hironori Hayashi Hisatoshi Nakagawara Hidehiro Tajima Hiroyuki Takamura Takashi Tani Masato Kayahara Hiroko Ikeda Tetsuo Ohta Yasuni Nakanuma | 2013 | World Journal of Gastroenterology2013，19，20： | 2 |
| 3 | Patterns of neural and plexus invasion of human pancreatic cancer and experimental cancer显示文摘 | Takukazu Nagakawa Masato Kayahara Tetsuo Ohta Keiichi Ueno Ichiro Konishi Itsuo Miyazaki | 1991 | International Journal of Pancreatology1991，，2： | 2 |
| 4 | PTD classification: proposal for a new classification of gastric cancer location based on physiological lymphatic flow显示文摘 | Shinichi Kinami Takashi Fujimura Eisuke Ojima Sachio Fushida Toshihiko Ojima Hiroshi Funaki Hideto Fujita Hiroyuki Takamura Itasu Ninomiya Genichi Nishimura Masato Kayahara Tetsuo Ohta Zen Yoh | 2008 | International Journal of Clinical Oncology2008，，4： | 2 |
| 5 | Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment显示文摘 | Satoshi Kondo Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Junji Furuse Hiroya Saito Toshio Tsuyuguchi Masakazu Yamamoto Masato Kayahara Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Satoshi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 2 |
| 6 | Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus显示文摘 | Masato Kayahara Takukazu Nagakawa Ichirou Konishi Keiichi Ueno Tetsuo Ohta Itsuo Miyazaki | 1991 | International Journal of Pancreatology1991，，2： | 1 |
| 7 | Surgical treatment of pancreatic cancer显示文摘 | Takukazu Nagakawa Ichirou Konishi Keiichi Ueno Tetsuo Ohta Takayoshi Akiyama Masato Kayahara Itsuo Miyazaki | 1991 | International Journal of Pancreatology1991，，1： | 1 |
| 8 | Long-term survivors after resection of carcinoma of the head of the pancreas: significance of histologically curative resection显示文摘 | Takukazu Nagakawa Hiromi Sanada Michiko Inagaki Junko Sugama Keiichi Ueno Ichiro Konishi Tetsuo Ohta Masato Kayahara Hirohisa Kitagawa | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，6： | 1 |
| 9 | Transectional gastrectomy: An old but renewed concept for early gastric cancer显示文摘 | Takashi Fujimura Sachio Fushida Masato Kayahara Tetsuo Ohta Shinichi Kinami Koichi Miwa | 2010 | Surgery Today2010，，5： | 1 |
| 10 | Long-term survivors after resection of carcinoma of the head of the pancreas: significance of histologically curative resection显示文摘 | Takukazu Nagakawa Hiromi Sanada Michiko Inagaki Junko Sugama Keiichi Ueno Ichiro Konishi Tetsuo Ohta Masato Kayahara Hirohisa Kitagawa | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，6： | 1 |
| 11 | Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice显示文摘 | Yasumichi Yagi Sachio Fushida Shinichi Harada Tomoya Tsukada Jun Kinoshita Katsunobu Oyama Hideto Fujita Itasu Ninomiya Takashi Fujimura Masato Kayahara Seigo Kinuya Masakazu Yashiro Kousei Hirakawa Tetsuo Ohta | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 1 |
| 12 | Synchronous Cancer of the Biliary Tract and Pancreas Associated with Anomalous Arrangement of the Pancreaticobiliary Ductal System显示文摘 | Nobuhiko Ueda Takukazu Nagakawa Tetsuo Ohta Masato Kayahara Keiichi Ueno Ichiroh Konishi Ryouhei Izumi Itsuo Miyazaki | 1992 | Journal of Clinical Gastroenterology1992，，2： | 1 |
| 13 | The results and problems of extensive radical surgery for carcinoma of the head of the pancreas显示文摘 | Takukazu Nagakawa MD Ichirou Konishi Keiichi Ueno Tetsuo Ohta Takayoshi Akiyama Masahiro Kanno Masato Kayahara Itsuo Miyazaki | 1991 | The Japanese Journal of Surgery1991，，3： | 1 |
| 14 | Three-dimensional studies on the structure of the tissue surrounding the superior mesenteric artery显示文摘 | Takukazu Nagakawa Kazuhiro Mori Masato Kayahara Tetsuo Ohta Keiichi Ueno Hiromi Sanada Itsuo Miyazaki | 1994 | International Journal of Pancreatology1994，，2： | 1 |
| 15 | Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment显示文摘 | Satoshi Kondo Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Junji Furuse Hiroya Saito Toshio Tsuyuguchi Masakazu Yamamoto Masato Kayahara Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Satoshi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 1 |
| 16 | MDCT findings of extrapancreatic nerve plexus invasion by pancreas head carcinoma: correlation with en bloc pathological specimens and diagnostic accuracy显示文摘 | Kentaro Mochizuki Toshifumi Gabata Kazuto Kozaka Yuki Hattori Yoh Zen Hirohisa Kitagawa Masato Kayahara Tetsuo Ohta Osamu Matsui | 2010 | European Radiology2010，，7： | 1 |
| 17 | Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment显示文摘 | Satoshi Kondo Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Junji Furuse Hiroya Saito Toshio Tsuyuguchi Masakazu Yamamoto Masato Kayahara Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Satoshi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 1 |
| 18 | Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus显示文摘 | Masato Kayahara Takukazu Nagakawa Ichirou Konishi Keiichi Ueno Tetsuo Ohta Itsuo Miyazaki | 1991 | International Journal of Pancreatology1991，，2： | 1 |
| 19 | Role of Nodal Involvement and the Periductal Soft-Tissue Margin in Middle and Distal Bile Duct Cancer显示文摘 | Masato Kayahara Takukazu Nagakawa Tetsuo Ohta Hirohisa Kitagawa Hidehiro Tajima Koichi Miwa | 1999 | Annals of Surgery1999，，1： | 1 |
| 20 | Long-term survivors after resection of carcinoma of the head of the pancreas: significance of histologically curative resection显示文摘 | Takukazu Nagakawa Hiromi Sanada Michiko Inagaki Junko Sugama Keiichi Ueno Ichiro Konishi Tetsuo Ohta Masato Kayahara Hirohisa Kitagawa | 2004 | Journal of Hepato-Biliary-Pancreatic Surgery2004，，6： | 1 |
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