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| 1 | 细胞因子、纤维化与青光眼滤过术的失败显示文摘目前对青光眼滤过术后滤过口瘢痕化的治疗虽有效,但常产生有害的副作用。对纤维化反应细胞学基础的研究会有助于抗纤维化治疗。伤口的修复包括血管新生和成纤维细胞的活化,它们都是在细胞因子的参与下完成的。细胞因子在这复杂的网络中相互作用促使成纤维细胞趋化、增殖和收缩,并刺激产生葡萄糖胺聚糖及胶原。干扰素可能会抑制上述纤维化反应的多个环节,其在眼部抗纤维化治疗中的作用尚需作进一步的评价。 | Mark C Gillies Tao Su 余克明 | 1993 | 国外医学(眼科学分册)1993，17，1： | 5 |
| 2 | Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment显示文摘 | Florian K.P. Sutter Judy M. Simpson Mark C. Gillies | 2004 | Ophthalmology2004，，11： | 3 |
| 3 | 黄斑囊样水肿患者自发荧光与黄斑色素密度的关系显示文摘目的探讨黄斑囊样水肿(CME)眼底自发荧光与黄斑色素密度的相关性,以提供对其预后有临床价值的技术参数。设计回顾性病例系列。研究对象2009年8月至2010年7月于北京同仁医院确诊CME的视网膜中央静脉阻塞、视网膜分支静脉阻塞及糖尿病视网膜病变的患者18例(24眼)。24只正常眼选自年龄及性别相匹配者。方法对所有患眼及正常对照眼行彩色眼底照相、荧光素眼底血管造影(FFA)及相干光断层扫描(OCT)确诊CME。采用海德堡公司HRA-2共焦激光扫描系统的IR(infrared)及FA(不注入荧光素钠)模式进行眼底自发荧光及黄斑色素密度的检测。黄斑色素密度按Zhang等分期法分为完整的黄斑色素、部分黄斑色素及黄斑色素缺失三级。采用Monte Carlo精确检验说明不同分级的黄斑色素密度与自发荧光的相关性,线性相关卡方检验分析两个变量之间的变化趋势。主要指标眼底自发荧光的分布及形态、黄斑色素的分布及密度。结果 24只CME眼自发荧光均为阳性(100%),并在黄斑区呈花瓣样表现,而正常对照眼的黄斑自发荧光均为阴性。CME眼中黄斑色素缺失22眼(91.7%),部分黄斑色素2眼(8.3%);正常对照眼黄斑色素密度均为完整的黄斑色素(100%)。黄斑色素密度与自发荧光的出现在本次研究中呈现负相关(χ2=45.123,P=0.0001)。结论 CME患者中黄斑色素密度大小与黄斑区自发荧光呈负相关,黄斑区自发荧光可做为其随诊的临床评价指标。 | 张新媛 Mark Gillies 朱晓青 王鑫 肖媛媛 顼晓琳 申令 高飞 | 2010 | 眼科2010，19，5： | 3 |
| 4 | Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells-possibilities and current limitations显示文摘BACKGROUND Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients.They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells(RGCs)and Müller glia.AIM To refine human-induced pluripotent stem cells(hiPSCs)differentiated into threedimensional(3D)retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream analyses.METHODS In this study we described,evaluated,and refined methods with which to generate Müller glia and RGC progenitors,isolated them via magnetic-activated cell sorting,and assessed their lineage stability after prolonged 2D culture.Putative progenitor populations were characterized via quantitative PCR and immunocytochemistry,and the ultrastructural composition of retinal organoid cells was investigated.RESULTS Our study confirms the feasibility of generating marker-characterized Müller glia and RGC progenitors within retinal organoids.Such retinal organoids can be dissociated and the Müller glia and RGC progenitor-like cells isolated via magnetic-activated cell sorting and propagated as monolayers.CONCLUSION Enrichment of Müller glia and RGC progenitors from retinal organoids is a feasible method with which to study cell type-specific disease phenotypes and to potentially generate specific retinal populations for cell replacement therapies. | Kristine Karla Freude Sarkis Saruhanian Alanna McCauley Colton Paterson Madeleine Odette Annika Oostenink Poul Hyttel Mark Gillies Henriette Haukedal Miriam Kolko | 2020 | World Journal of Stem Cells2020，12，10： | 2 |
| 5 | A positive analysis of deposit insurance provision: Regulatory competition among European Union countries显示文摘 | Merwan H. Engineer Paul Schure Mark Gillis | 2013 | Journal of Financial Stability2013，，4： | 1 |
| 6 | Intravitreal Triamcinolone Prior to Laser Treatment of Diabetic Macular Edema显示文摘 | Mark C. Gillies Ian L. McAllister Meidong Zhu Wanling Wong Damien Louis Jennifer J. Arnold Tien Y. Wong | 2011 | Ophthalmology2011，，5： | 1 |
| 7 | Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray显示文摘 | David L. Morse Yoga Balagurunathan Galen Hostetter Maria Trissal Narges K. Tafreshi Nancy Burke Mark Lloyd Steven Enkemann Domenico Coppola Victor J. Hruby Robert J. Gillies Haiyong Han | 2010 | Biochemical Pharmacology2010，，5： | 1 |
| 8 | The relationship between fibler modulas and S2 angle显示文摘 | Mark R E Gillis P P | 1973 | Tappi1973，56，4： | 1 |
| 9 | Intravitreal Triamcinolone for Refractory Diabetic Macular Edema显示文摘 | Mark C. Gillies Florian K.P. Sutter Judy M. Simpson Jorgen Larsson Haipha Ali Meidong Zhu | 2006 | Ophthalmology2006，，9： | 1 |
| 10 | Ophthalmologic complications of antiviral therapy in hepatitis C treatment显示文摘Antiviral therapy consisting of interferon-alpha and ribavirin for chronic hepatitis C infection is associated with multi-system side-effects.Ophthalmologic complications are common and can be classified into two groups:interferon-associated retinopathy and atypical adverse events.Interferon-associated retinopathy has been investigated by multiple observational studies that have found widely divergent results.The clinical importance of this complication is,consequently,controversial.This review examines the literature with the specific goal of identifying the most important ophthalmologic issues facing the hepatologist prescribing antiviral therapy.Accordingly,it assesses the incidence of interferon-associated retinopathy,as well as its risk factors,pathogenesis,clinical manifestations and options for management using data from the observational studies.The likely benefit of a screening program,especially one targeting patients with the highest risk of developing interferon-associated retinopathy,is analysed.Atypical ophthalmologic adverse events occur less frequently than interferon-associated retinopathy during antiviral therapy for chronic hepatitis C infection.They often,however,lead to irreversible vision loss.We examine the reports of these adverse events-in individual case reports or case series and in the observational studies investigating interferon-associated retinopathy-to describe the spectrum of these adverse events,the likely outcome for patients and to highlight the most important areas of future clinical research. | Roderick O'Day Mark C Gillies Golo Ahlenstiel | 2013 | World Journal of Gastroenterology2013，19，45： | 1 |
| 11 | Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion显示文摘 | Julia A. Haller Francesco Bandello Rubens Belfort Mark S. Blumenkranz Mark Gillies Jeffrey Heier Anat Loewenstein Young-Hee Yoon Marie-Louise Jacques Jenny Jiao Xiao-Yan Li Scott M. Whitcup | 2010 | Ophthalmology2010，，6： | 1 |
| 12 | Relation Between Reduction of Foveal Thickness and Visual Acuity in Diabetic Macular Edema Treated With Intravitreal Triamcinolone显示文摘 | J?rgen Larsson Meidong Zhu Florian Sutter Mark C. Gillies | 2005 | American Journal of Ophthalmology2005，，5： | 1 |
| 13 | Diagnosis and interventions for central serous chorioretinopathy: review and update显示文摘 | Godfrey Quin Gerald Liew I‐Van Ho Mark Gillies Samantha Fraser‐Bell | 2012 | Clinical & Experimental Ophthalmology2012，，2： | 1 |
| 14 | A Randomized Clinical Trial of a Single bose of Intravitreal Triamcinolone Acetonide for Neovascular Age- Related Macular Degeneration: One - Year Results显示文摘 | Gillies Mark C Simpson Judy M Luo Wei | 2003 | Arch Ophthalmol2003，121，5： | 1 |
| 15 | A stimulus-responsive contrast agent for ultrasound molecular imaging显示文摘 | Mark A. Borden Hua Zhang Robert J. Gillies Paul A. Dayton Katherine W. Ferrara | 2007 | Biomaterials2007，，5： | 1 |
| 16 | Effects of Propofol and Thiopental on Maternal and Fetal Cardiovascular and Acid-base Variables in the Pregnant Ewe显示文摘 | Eli Alon Robert H. Ball Mark H. Gillie Julian T. Parer Mark A. Rosen Sol M. Shnider | 1993 | Anesthesiology1993，，3： | 1 |
| 17 | Interferon-alpha 2b inhibits proliferation of human Tenon’s capsule fibroblasts显示文摘 | Mark Gillies Tao Su Mark Sarossy Fred Hollows | 1993 | Graefe’s Archive for Clinical and Experimental Ophthalmology1993，，2： | 1 |
| 18 | Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice显示文摘 | Arig Ibrahim-Hashim Heather H. Cornnell Dominique Abrahams Mark Lloyd Marilyn Bui Robert J. Gillies Robert A. Gatenby | 2012 | The Journal of Urology2012，，2： | 1 |
| 19 | The Impact of Anti-Vegf Treatment on Quality of Life in Neovascular Age-Related Macular Degeneration显示文摘 | Robert P. Finger Robyn H. Guymer Mark C. Gillies Jill E. Keeffe | 2013 | Ophthalmology2013，，： | 1 |
| 20 | Factors controlling the spatial and temporal variability of dust emissions显示文摘 | John A. Gillies William G. Nickling Vicken Etyemezian James King Mark Sweeney | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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