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| 1 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 2 | Distributed nonlinear fiber chirped - pulse amplifier system 显示文摘 | Marc Hanna Dimitris Papadopoulos Frederic Druon | 2009 | Optics Express2009，17，10： | 1 |
| 3 | 异种胶原蛋白基质与上皮下结缔组织移植物:牙龈退缩不同种治疗方法的系列病例报道显示文摘目的:学者们最近提出,异种胶原蛋白基质可替代结缔组织移植物用于牙龈退缩的治疗。采用这种胶原蛋白基质,能够避免二次手术.并且可以降低手术并发症。材料与方法:这种新的胶原蛋白基质已用于不同的临床情况.并设计了自身同侧对照实验来比较疗效,即一侧采用结缔组织移植物(CTG).另一侧采用异种胶原蛋白基质。本研究样本量为17颗牙龈退缩的患牙,均接受了冠向复位瓣(CAF)的治疗,其中9颗用结缔组织移植物治疗,8颗用胶原蛋白基质治疗。结果:结缔组织移植组平均牙龈高度恢复了2.00mm.胶原蛋白基质组的牙龈高度也恢复了2.00mm,两种治疗方法之间无显著统计学差异。 | Gregoire Chevalier Selma Cherkaoui Hanna Kruk Xavier Bensaid Marc Danan 黄玲(译) 李煌(审) | 2018 | 中国口腔医学继续教育杂志2018，21，5： | 1 |
| 4 | Cost-effectiveness of treating hyperlipidemia in the presence of diabetes显示文摘 | Steven AG Louis C Hanna Z Marc D | 2000 | Circulation2000，102，： | 1 |
| 5 | Continuous Preperitoneal Infusion of Ropivacaine Provides Effective Analgesia and Accelerates Recovery after Colorectal Surgery: A Randomized, Double-blind, Placebo-controlled Study显示文摘 | Marc Beaussier Hanna El’Ayoubi Eduardo Schiffer Maxime Rollin Yann Parc Jean-Xavier Mazoit Louisa Azizi Pascal Gervaz Serge Rohr Celine Biermann André Lienhart Jean-Jacques Eledjam | 2007 | Anesthesiology2007，，3： | 1 |
| 6 | Erratum to: Early postoperative prophylactic noninvasive ventilation after major lung resection in COPD patients: a randomized controlled trial显示文摘 | Christine Lorut Aurélie Lefebvre Benjamin Planquette Laurent Quinquis Hervé Clavier Nicola Santelmo Halim Abou Hanna Fran?ois Bellenot Jean-Fran?ois Regnard Marc Riquet Pierre Magdeleinat Guy Meyer Nicolas Roche Marie-Pierre Revel Gérard Huchon Joel Coste | 2014 | Intensive Care Medicine2014，，3： | 1 |
| 7 | Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma:Real-life Data on Liver Disease,Treatment and Prognosis显示文摘Background and Aims:Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)have common features and differences.This real-life study investigated their characteristics,treatment modalities,and prognoses.Methods:This retrospective comparative study was performed in 1,075 patients seen at one tertiary center between January 2008 and December 2020.Overall survival(OS)was estimated by the Kaplan-Meier method.Subclassification of iCCAs after histological and radiological review,and molecular profiling was performed.Results:HCCs patients were more likely to have early-stage disease than iCCA patients.iCCA patients were more likely to be female,especially those patients without cirrhosis(43%vs.17%).Cirrhosis was prominent among HCC patients(89%vs.34%),but no difference in underlying liver disease among cirrhotic patients was found.OS of HCC patients was 18.4(95%CI:6.4,48.3)months,that of iCCA patients was 7.0(95%CI:3.4,20.1)months.OS of Barcelona Clinic Liver Cancer C HCC patients was 7.8(95%CI:4.3,14.2)months,that of advanced/metastatic iCCA patients was 8.5(95%CI:5.7,12.3)months.In patients treated with sorafenib,OS was longer in HCC patients who received subsequent tyrosine kinase inhibitor therapies.No significant OS difference was found between iCCA patients with and without cirrhosis or according to histological subtype.A targetable molecular alteration was detected in 50%of the iCCA patients.Conclusions:In this French series,cirrhosis was common in iCCA,which showed etiological factors comparable to those of HCC,implying a distinct oncogenic pathway.Both entities had a dismal prognosis at advanced stages.However,systemic therapies sequencing in HCC and molecular profiling in iCCA offer new insights. | Xavier Adhoute Olivia Pietri Guillaume Pénaranda Thomas Wolf Patrick Beaurain Olivier Monnet Arthur Laquière Justine Bonomini Frédéric Neumann Olivier Levrel Jean-Pascal Buono Xavier Hanna Paul Castellani HervéPerrier Marc Bourliere Rodolphe Anty | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
| 8 | Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease显示文摘AIM:To investigate a possible genetic influence of claudin(CLDN)1,CLDN2 and CLDN4 in the etiology of inflammatory bowel disease.METHODS:Allelic association between genetic regions of CLDN1,CLDN2 or CLDN4 and patients with inflammatory bowel disease,Crohn's disease(CD)or ulcerative colitis were investigated using both a casecontrol study approach(one case randomly selected from each of 191 Swedish inflammatory bowel disease families and 333 controls)and a family-based study(463 non-Swedish European inflammatory bowel disease-families).A nonsynonymous coding single nucleotide polymorphism in MORC4,located on the same linkage block as CLDN2,was investigated for association,as were two novel CLDN2 single nucleotide polymorphism markers,identified by resequencing.RESULTS:A single nucleotide polymorphism marker(rs12014762)located in the genetic region of CLDN2 was significantly associated to CD(case-control allelic OR = 1.98,95%CI:1.17-3.35,P = 0.007).MORC4 was present on the same linkage block as this CD marker.Using the case-control approach,a significant association(case control allelic OR = 1.61,95%CI:1.08-2.41,P = 0.018)was found between CD and a nonsynonymous coding single nucleotide polymorphism(rs6622126)in MORC4.The association between the CLDN2 marker and CD was not replicated in the familybased study.Ulcerative colitis was not associated to any of the single nucleotide polymorphism markers.CONCLUSION:These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a Swedish population. | Jan Sderman Elisabeth Norén Malin Christiansson Hanna Bragde Raphaele Thiébaut Jean-Pierre Hugot Curt Tysk Colm A O'Morain Miquel Gassull Yigael Finkel Jean-Frédéric Colombel Marc Lémann Sven Almer | 2013 | World Journal of Gastroenterology2013，19，30： | 0 |
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