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| 1 | Pingwei capsules improve gastrointestinal motility in rats with functional dyspepsia显示文摘OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC. | Liang Qiankun Mao Lanfang Du Xiaojuan Li Yunxia Yan Yuan Liang Jingjing Liu Junhong Wang Longde Li Hongfang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 2 | Optimization of cyclical process for CO coupling regeneration reactions 显示文摘 | Wang Baowei Ma Xinbin Xu Genhui Mao Lanfang | 2000 | Computers & Chemical Engineering2000，24，27： | 1 |
| 3 | Preliminary analysis of polonium-210contamination for China Lead-based Research Re-actor显示文摘 | MAO Lanfang DANG Tongqiang PAN Ling-yang | 2014 | Fusion Engineering and Design2014，70，： | 1 |
| 4 | Lipid Biomarkers and Their Stable Carbon Isotopes in Ancient Seep Carbonates from SW Taiwan, China显示文摘Four massive brecciated, chimney-like, and slender pipe network carbonate samples(JA-4, JA-5, JX-8 and BG-12) were collected from southwestern Taiwan, which were suggested to have formed as a result of anaerobic oxidization of methane(AOM). Considering that the environmental conditions of the carbonates precipitation and the sources of carbon and organic matter need to be further declared, molecular fossils and compound-specific carbon isotopic investigations of the carbonates were conducted in this study. According to lipid biomarkers of 2,6,10,15,19-pentamethyleicosane(PMI) and squalane diagnostic to methanotrophic archaea, as well as the extremely low δ^(13)C values(as low as -1^(13).4‰) detected in samples JA-4, JA-5 and JX-8, these carbonates were revealed to be a result of AOM. Based on the varied δ^(13)C values of characteristic archaea biomarkers in specific samples, biogenic methane was proposed to be responsible for the formation of samples JA-4 and JA-5, whereas a mixed carbon source of ^(13)C-depleted methane and ^(13)C-enriched residual CO_2 from methanogenesis was suggested for the carbonate of JX-8 due to the co-occurrence of a highly positive δ^(13) C_(carb) value(+8‰) and a moderate ^(13)C depletion of PMI. The low content of AOM-related biomarkers and the absence of indicators for ANME-2 suggested that these carbonates were formed in weak seep settings. By comparison, no typical lipid biomarkers for methanotrophic archaea was detected in carbonate BG-12. The short-chain and long-chain n-alkanes accounted for 30% and 45% of all hydrocarbons, respectively, with a CPI value of 1.2, suggesting that the n-alkanes were derived from both marine organisms and terrestrial inputs. A low thermal maturity could be revealed by the incomplete equilibrium value of the C^(31)αβ 22S/(22S+22R) ratio(0.5), and the carbonate BG-12 was probably deposited in a suboxic condition indicated by a value of Pr/Ph ratio(2.5). | GUAN Hongxiang XU Lanfang WANG Qinxian CHEN Duofu WU Nengyou MAO Shengyi | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 0 |
| 5 | 15-PGDH:a potential target for the treatment of muscle atrophy显示文摘Muscle atrophy is one of the most common and destructive events in chronic diseases.It is characterized by a decrease in the cross-sectional area of muscle fiber,myonuclear number,protein content,and muscle strength and an increase in fatigability.Muscle atrophy not only causes a decline in the quality of life of patients,but also poses a burden on society[1].The occurrence of muscle atrophy is related to many factors.From a macro point of view,there are age and disuse.At the micro level,the rate of protein degradation exceeds the rate of protein synthesis[2,3].To date,a plethora of therapeutic strategies in the treatment of muscle atrophy has been successfully developed,such as nutritional interventions,physical exercise,and electroacupuncture therapy,all of which can prevent and rescue muscle atrophy[4].However,there is no effective drug to treat muscle atrophy.Therefore,it is very necessary to better understand the fine-tuning network for the occurrence and development of muscle atrophy and it is also helpful to provide new strategies for the treatment and prevention of muscle atrophy in the future. | Hui Mao Yiyuan Yang Linxi Chen Lanfang Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 0 |
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