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| 1 | Applicability of the PRECISE-DAPT score in elderly patients with myocardial infarction显示文摘Background Elderly patients with acute coronary syndromes(ACS)are at higher risk both for ischemic and bleeding complications.Current guidelines recommend the PRECISE-DAPT score for bleeding risk stratification in this setting,but no study assessed its applicability in elderly patients.This study aimed to assess the performance of the PRECISE-DAPT score in a series of non-selected elderly patients with ACS from routine clinical practice.Methods The IFFANIAM registry included prospectively patients aged>75 years with ST segment elevation myocardial infarction(STEMI).Main outcome measured was the incidence of relevant bleeding after discharge(bleeding leading to hospital readmission,need for transfusion,intervention,stop of antithrombotic drugs or death).Bleeding risk was classified:(A)according to PRECISE-DAPT values above or not the recommended cut-off point(>25);and(B)according to the quartiles of PRECISE-DAPT values observed in the IFFANIAM series(QI:<30;Q2:30-35;Q3:36-44;Q4:>45).Results A total of 208 patients were included.Mean age was 81.9±4.5 years.Most patients(92.6%)had a PRECISE-DAPT value>25.A total of 25 patients(12.0%)had bleeding events and 49 patients(23.6%)died.No significant differences regarding the incidence of bleeding were observed according to the recommended cutt of point>25.However,a progressive increase in the incidence of bleeding was observed across PRECISE-DAPT quartiles observed in this series(P=0.038).Conclusions The vast majority of elderly patients have PRECISE-DAPT values above the recommended cut-off point for bleeding risk.Using different cut-off points could be a more rational approach for predicting bleeding risk in these complex patients. | Albert Ariza-Sole Francesc Formiga Manuel Martinez-Selles Maria T Vidan Jaime Aboal | 2018 | Journal of Geriatric Cardiology2018，15，12： | 5 |
| 2 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 3 | Environmental im- pacts of intensive aquacuhure in marine water 显示文摘 | ANTONIO T CARLOS M MANUEL P M | 2000 | Water Re- search2000，34，1： | 1 |
| 4 | Analysis of the porgnostic signficance of cytosoilc determination of CA125,CEA,SCC-AG in patients with NSCLC显示文摘 | Antonio LP Manuel D Antonio T | 1996 | Cancer1996，77，6： | 1 |
| 5 | Geographic localization of knowledge spillovers as evidenced by patent citations显示文摘 | Manuel T Rebecca H | 1993 | Quarterly Journal of Economics1993，108，3： | 1 |
| 6 | The dwarfing mechanism of citrus rootstockaFay-A 418 and 23 isrelated to competition between vegetative and reproductive growth显示文摘 | Lliso I Juan B F Manuel T | 2004 | Tree Physiology2004，24，2： | 1 |
| 7 | Age-dependentaccumulation of soluble amyloid p (Ap) oligomers reversesthe neuroprotective effect of soluble amyloid precursor protein-(sAPP) by modulating phosphatidylinositol 3-kinase (PI3K) /Akt-GSK-3 pathway in Alzheimer mouse model 显示文摘 | Sebastian J Manuel T Marisa V | 2011 | J BiolChem2011，286，18： | 1 |
| 8 | Assessing competence in the use of motivational interviewing显示文摘 | Moyers TB Martin T Manuel JK | 2005 | J Subst Abuse Treat2005，28，1： | 1 |
| 9 | Analyzing a fLrm' s In- ternational Portfolio of Technological Knowledge: A Declarative Ontology-based OWL Approach for Patent Documents显示文摘 | Maria B E Manuel N Nuria H T | 2013 | Ad- vanced Engineering Informatics2013，27，3： | 1 |
| 10 | Ab- normal behavior detection using dominant sets 显示文摘 | MANUEL A AHDREA T ALVARO S M | 2014 | Machine Vision and Applications2014，25，5： | 1 |
| 11 | TIF1-delta,anovel HP1-interacting member of the transcriptional interme-di-ary factor 1(TIF1)family expressed by elongating sper-matids显示文摘 | Konstantin K Marius T Manuel M | 2004 | Biol Chem2004，279，48： | 1 |
| 12 | Nanofiller incorporated poly (vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) composite electrolytes for lithium batteries显示文摘 | A Manuel Stephan Kee Suk Nahm T Prem Kumar | 2006 | Journal of Power Sources2006，159，2： | 1 |
| 13 | Analysis of the prognostic signilcance of cytosolic determination of CA125, CEA, SCC in patients with NSCLC显示文摘 | ANTONIO LP MANUEL D ANTONIO T | 1996 | Cancer1996，77，6： | 1 |
| 14 | GPR54 and Kisspeptin in reproduction 显示文摘 | Manuel T S | 2006 | Hu- man Reproduction Update2006，12，5： | 1 |
| 15 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 16 | Knowledge spillovers and patent citations : evidence from a survey of innovators 显示文摘 | Jaffe A B Manuel T Michael S F | 2000 | Industrial Technology and Productivity2000，90，2： | 1 |
| 17 | Runx3,a novel tumor suppressor,is frequently inactivated in gastric cancer by protein mislocalization显示文摘 | Kosei Ito Liu Q Manuel S T | 2005 | Cancer Res2005，65，17： | 1 |
| 18 | Effect of cellulases, solvent type and particle size distribution on the extraction of chlorogenic acid and other phenols from spent coffee grounds显示文摘 | Manuel P Abigaille G T Mads P | 2007 | American Journal of Food Technology2007，2，7： | 1 |
| 19 | Melt coaxial electrospinning: a versatile method for the encapsulation of solid materials and fabrication of phase change nanofibers 显示文摘 | MCCANN JESSE T MARQUEZ MANUEL XIA You-Nan | 2006 | Nano Letters2006，6，12： | 1 |
| 20 | Controlled release of doxorubicin loaded within magnetic thermo-responsive nanocarriers under magnetic and thermal actuation in a microfluidic channel显示文摘 | Manuel P L Andrea T Andreas R | 2012 | ACS Nano2012，6，10： | 1 |
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