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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Concerning trend removal in electrochemical noise measurements显示文摘 | Mansfield F Sun Z Hsu C H | 2001 | Corrosion Science2001，43，： | 1 |
| 3 | Concerning trend removal in electrochemical noise measurements显示文摘 | Mansfield F Sun Z Hsu C H | 2001 | Corrosion Science2001，3，43： | 1 |
| 4 | Construction of internal cDNA competitors for mearuring IL-10 and IL-12 cytokine gene expression in swine显示文摘 | Urban J F Murtaugh M P | 1998 | Vet Immunol Immunopathol1998，65，： | 1 |
| 5 | Construction of internal cDNA competitors for mearuring ID 10 and IL-12 cytokine gene expression in swine显示文摘 | Mansfield L S Urban J F Murtaugh M P | 1998 | Vet Immunol Immuno-Pathol1998，65，： | 1 |
| 6 | High refractory, low misfit Ru-containing single-crystal superalloys显示文摘 | CARROLL L J FENG Q MANSFIELD J F POLLOCK T M | 2006 | Metallurgical and Materials Transactions A2006，37，10： | 1 |
| 7 | Elemental partitioning in Ru-containing nickel-base single crystal superalloys 显示文摘 | CARROLL L J FENG Q MANSFIELD J F POLLOCK T M | 2009 | Materials Science and Engineering A2009，457，： | 1 |
| 8 | Reservoir petrology of analogous Middle Jurassic sand- stones from Haltenbanken, Norway, and Jameson Land, east Greenland显示文摘 | Cheatwood C J Mansfield C F Cheatwood C J | 1986 | AAPG Bulletin1986，70，5： | 1 |
| 9 | On the creep of directionally solidified MoSi2-Mo5Si3 eutectics显示文摘 | Mason D P Van Aken D C Mansfield J F | 1995 | Acta metall Mater1995，43，3： | 1 |
| 10 | Sucrose phosphate synthase expression influences poplar phenology显示文摘 | Park J Y Canam T Kang K Y Unda F Mansfield S D | | 0，，29： | 1 |
| 11 | Complications and failures of subclavian - vein catheterization 显示文摘 | Mansfield P F Hohn D C Fomage B D | 1994 | N Engl J Med1994，331，26： | 1 |
| 12 | Multi - institu- tional trial of preoperative ehemoradiotherpy in patients with poten- tially resectable gastric carcinoma 显示文摘 | AJANI J A MANSFIELD P F JANJAN N | 2004 | J Clin Onel2004，22，14： | 1 |
| 13 | A high dietary concentration of inulin is necessary to reduce the incidence of swine dysentery in pigs experimentally challenged with Brachyspira hyodysenteriae 显示文摘 | Hansen C F Herndndez A Mansfield J | 2011 | The British Journal of Nutrition2011，106，10： | 1 |
| 14 | Guard cell cation channels are involved in Na+- induced stomatal closure in a halophyte 显示文摘 | VERY A ROBINSON M F Mansfield T A | 1998 | The Plant Journal1998，14，5： | 1 |
| 15 | Development of a clinical severity index for dogs with acute pancreatitis显示文摘 | MANSFIELD C S JAMES F E ROBERTSON I D | 2008 | J Am Vet Med Assoc2008，233，6： | 1 |
| 16 | Corrosion Behavior of Copper Alloys, Stainless Steels and Titanium in the Seawater显示文摘 | Mansfield F Liu G Xiao H | 1994 | Corrosion science1994，36，12： | 1 |
| 17 | Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade显示文摘 | Weber MA Mansfield TA Alessi F | 2016 | Blood Press2016，25，2： | 1 |
| 18 | A Technical Review of Electro-Chemical Techniques Applied to Microbiologically Influenced Corrosion显示文摘 | Mansfield F Little B | 1991 | Corrosion Science1991，32，3： | 1 |
| 19 | Bilateral breast carcinoma:risk factors and outcomes for patients with synchronous and metachronous disease显示文摘 | Heron D E Komarnicky L T Hyslop T Schwartz G F Mansfield C M | 2000 | Cancer2000，88，： | 1 |
| 20 | Changes in growth and serum growth hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty显示文摘 | MANSFIELD M J RUDLIN C R CRIGLER J F | 1988 | J Clin Endocrinol Metab1988，66，： | 1 |
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