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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Cholangiocarcinoma and malignant bile duct obstruction: A review of last decades advances in therapeutic endoscopy显示文摘In the last decades many advances have been achieved in endoscopy, in the diagnosis and therapy of cholangiocarcinoma, however blood test, magnetic resonance imaging, computed tomography scan may fail to detect neoplastic disease at early stage, thus the diagnosis of cholangiocarcinoma is achieved usually at unresectable stage. In the last decades the role of endoscopy has moved from a diagnostic role to an invaluable therapeutic tool for patients affected by malignant bile duct obstruction. One of the major issues for cholangiocarcinoma is bile ducts occlusion, leading to jaundice, cholangitis and hepatic failure. Currently, endoscopy has a key role in the work up of cholangiocarcinoma, both in patients amenable to surgical intervention as well as in those unfit for surgery or not amenable to immediate surgical curative resection owing to locally advanced or advanced disease, with palliative intention. Endoscopy allows successful biliary drainage and stenting in more than 90% of patients with malignant bile duct obstruction, and allows rapid reduction of jaundice decreasing the risk of biliary sepsis. When biliary drainage and stenting cannot be achieved with endoscopy alone, endoscopic ultrasound-guided biliary drainage represents an effective alternative method affording successful biliary drainage in more than 80% of cases. The purpose of this review is to focus on the currently available endoscopic management options in patients with cholangiocarcinoma. | Helga Bertani Marzio Frazzoni Santi Mangiafico Angelo Caruso Mauro Manno Vincenzo Giorgio Mirante Flavia Pigò Carmelo Barbera Raffaele Manta Rita Conigliaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 8 |
| 3 | 单个汽球 enteroscopy : 技术方面和临床的应用显示文摘 The small bowel has long been considered a black box for endoscopists because of its long length and the presence of multiple complex loop. Most of the small bowel is inaccessible by traditional endoscopic means. In addition, radiographic studies have significant limitations with regard to diagnostic yield, and surgery is an invasive alternative. This limitation was overcome through the development of balloon enteroscopy that becomes established throughout the world for diagnostic and therapeutic examinations of the small bowel. The single-balloon enteroscope (SBE) system (Olympus, Tokyo, Japan) was introduced into the commercial market in 2007. Several study demonstrated its efficacy and safety. Early reports on the use of singleballoon enteroscopy have suggested a high diagnostic yield and similar therapeutic potential to that of the double-balloon endoscope. SBE is viable technique for in the management of small bowel disease. Technically, it is easy to perform, may be efficient, and in the literature data available, seems to provide high diagnostic and therapeutic yield. | Mauro Manno Carmelo Barbera Helga Bertani Raffaele Manta Vincenzo Giorgio Mirante Emanuele Dabizzi Angelo Caruso Flavia Pigo Giampiero Olivetti Rita Conigliaro | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，2： | 8 |
| 4 | Pathophysiological characteristics of the various forms of gastro-oesophageal reflux disease显示文摘 | M. Frazzoni M. Manno E. De Micheli V. Savarino | 2006 | Digestive and Liver Disease2006，，9： | 2 |
| 5 | Endoscopic treatment of gastrointestinal fistulas using an over-the-scope clip (OTSC) device: Case series from a tertiary referral center显示文摘 | R. Manta M. Manno H. Bertani C. Barbera F. Pigò V. Mirante E. Longinotti G. Bassotti R. Conigliaro | 2011 | Endoscopy2011，，06： | 2 |
| 6 | AAV-2 mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B显示文摘 | Manno C S Chew A J Hutchison S | 2003 | Blood2003，101，8： | 1 |
| 7 | The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal Prognosis in IgANephropathy显示文摘 | Tores DD Rossini M Manno C | 2008 | Kidney Int2008，73，3： | 1 |
| 8 | Deep impact of ultrasound in the intensive care unit:the ' ICU-sound ' protocol显示文摘 | Manno E Navarra M Faccio L | 2012 | Anesthesiology2012，117，： | 1 |
| 9 | An 'evidence-based' survey of therapeutic options for IgA nephropathy: Assessment and Criticism 显示文摘 | Strippoli GF Manno C Schena FP | 2003 | Am J Kidney Dis2003，41，6： | 1 |
| 10 | Status epilepticus: current treatment stra tegies 显示文摘 | Manno EM | 2011 | Neurohospitalist2011，1，1： | 1 |
| 11 | Primary renal lymphoma does exist:case report and review of the literature显示文摘 | Stallone G Infante B Manno C | 2000 | J Nephrol2000，13，5： | 1 |
| 12 | Subarachnoid hemorrhage, neurointensive care and aneurysm repair 显示文摘 | Wijdicks EF Kallmes DF Manno EM | 2005 | Mayo Clin Proc2005，80，： | 1 |
| 13 | Clinical spectrum of reversible posterior leukoencephalopathy syndrome显示文摘 | Lee VH Wijdicks EF Manno EM | 2008 | Arch Neurol2008，65，2： | 1 |
| 14 | Cabergoline: a safe, easy, cheap, and effective drug for prevention/ treatment of ovarian hyperstimulation syndrome? 显示文摘 | Manno M Tomei F Marchesan E | 2005 | Eur J Obstet Gynecol Reprod Biol2005，122，1： | 1 |
| 15 | The effects of a visual fidelity criterion of the encoding of images 显示文摘 | MANNOS J SAKRISON D | 1974 | IEEE Transactions on Information Theory1974，20，4： | 1 |
| 16 | The effects of a visual fidelity criterion on the encoding of images 显示文摘 | Mannos J L Sakrison D J | 1974 | IEEE Trans on Information Theory1974，20，4： | 1 |
| 17 | The effect of a visual fidelity criterion on the encoding of images 显示文摘 | Mannos J L Sakrison D J | 1974 | IEEE Transactions on Inform Theory1974，20，2： | 1 |
| 18 | Mechanisms of antimotion sickness drugs显示文摘 | Manno JE Wood MJ | 1987 | Aviat Space Environ Med1987，58，9： | 1 |
| 19 | Risk stratification and primary prevention of sudden cardiac death: sudden death prevention 显示文摘 | Obias Manno D Wijetunga M | 2004 | AACN Clin Issues2004，15，3： | 1 |
| 20 | lntracerebral Hemorrhage New Challenges and Steps Forward显示文摘 | Jose Javier Provencio lvan gocha Ferreira Da Silva Edward Michael Manno | 2015 | Neurosurg Clin N Am2015，，24： | 1 |
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