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3篇 您的检索式:作者名="Manel Amri"
    题名 作者 年代 出处 被引量
1In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus显示文摘Razika Zeghir-Bouteldja Manel Amri Saliha Aitaissa Samia Bouaziz Dalila Mezioug Chafia Touil-Boukoffa Claudio Genchi 2009Journal of Parasitology Research2009,,:1
2A protective effect of the laminated layer on Echinococcus granulosus survival dependent on upregulation of host arginase显示文摘Manel Amri Chafia Touil-Boukoffa 2015Acta Tropica2015,,:1
3In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol显示文摘Objective: To study in vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol as an alternative therapy for Cystic echinococcosis. Methods: Effect of a commonly used herbal product and ginger(Zingiber officinale) towards protoscoleces(PSC) and cyst wall in vitro was studied. The effect of [6]-gingerol, and the pungent constituent of ginger, was also evaluated on PSC culture. Furthermore, the activity of both extracts in association with interferon-gamma(IFN-γ) on PSC co-cultured with mononuclear cells of hydatic patients was evaluated. The nitric oxide(NO) production was measured in each co-culture. Results: Ginger exhibited a concentration- and time-dependent cytotoxic effect against PSC and cyst wall. Interestingly, ginger was more effective than the [6]-gingerol. Moreover, additional parasitic effect between extracts and IFN-γ are also observed in co-cultures. Furthermore, both extracts attenuated the NO production elicited by this infection or by the IFN-γ. Conclusions: Ginger has an important anti-hydatic effect in vitro. This effect is amplified in the presence of IFN-γ. Moreover, this herbal product may protect against host's cell death by reducing the high levels of NO. Ginger may act, at least, through the [6]-gingerol. All our data suggest the promising use of ginger in the treatment of Echinococcus granulosus infection.Manel Amri Chafia Touil-Boukoffa 2016Asian Pacific Journal of Tropical Medicine2016,9,8:1
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