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| 1 | Efficacy and safety of over-the-scope clip: Including complications after endoscopic submucosal dissection显示文摘AIM: To retrospectively review the results of over-thescope clip (OTSC) use in our hospital and to examine the feasibility of using the OTSC to treat perforations after endoscopic submucosal dissection (ESD). METHODS: We enrolled 23 patients who presented with gastrointestinal (GI) bleeding, fistulae and perforations and were treated with OTSCs (Ovesco Endoscopy GmbH, Tuebingen, Germany) between November 2011 and September 2012. Maximum lesion size was defined as lesion diameter. The number of OTSCs to be used per patient was not decided until the lesion was completely closed. We used a twin grasper (Ovesco Endoscopy GmbH, Tuebingen, Germany) as a grasping device for all the patients. A 9 mm OTSC was chosen for use in the esophagus and colon, and a 10 mm device was used for the stomach, duodenum and rectum. The overall success rate and complications were evaluated, with a particular emphasis on patients who had undergone ESD due to adenocarcinoma. In technical successful cases we included not only complete closing by using OTSCs, but also partial closing where complete closure with OTSCs is almost difficult. In overall clinical successful cases we included only complete closing by using only OTSCs perfectly. All the OTSCs were placed by 2 experienced endoscopists. The sites closed after ESD included not only the perforation site but also all defective ulcers sites.RESULTS: A total of 23 patients [mean age 77 years (range 64-98 years)] underwent OTSC placement during the study period. The indications for OTSC placement were GI bleeding (n = 9), perforation (n = 10), fistula (n = 4) and the prevention of post-ESD duodenal artificial ulcer perforation (n = 1). One patient had a perforation caused by a glycerin enema, after which a fistula formed. Lesion closure using the OTSC alone was successful in 19 out of 23 patients, and overall success rate was 82.6%. A large lesion size (greater than 20 mm) and a delayed diagnosis (more than 1 wk) were the major contributing factors for the overall unsuccessful clinical cases. The location of the unsuccessful lesion was in the stomach. The median operation time in the successful cases was 18 min, and the average observation time was 67 d. During the observation period, none of the patients experienced any complications associated with OTSC placement. In addition, we successfully used the OTSC to close the perforation site after ESD in 6 patients. This was a single-center, retrospective study with a small sample size. CONCLUSION: The OTSC is effective for treating GI bleeding, fistulae as well as perforations, and the OTSC technique proofed effective treatment for perforation after ESD. | Noriko Nishiyama Hirohito Mori Hideki Kobara Kazi Rafiq Shintarou Fujihara Mitsuyoshi Kobayashi Makoto Oryu Tsutomu Masaki | 2013 | World Journal of Gastroenterology2013，19，18： | 42 |
| 2 | Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism显示文摘植物 metabolomics 作为一个强大的工具发展了检验基因功能并且获得更深的卓见进植物房间的生理学。在这研究,我们屏蔽了 Arabidopsis 线 overexpressing 米饭全身(FL ) 用煤气的 chromatographytime-of-flight 团 spectrometry (GCTOF/MS ) 的 cDNAs (米饭狐狸 Arabidopsis 线) 基于技术识别引起了新陈代谢的变化的米饭基因。这个屏蔽系统允许显示出改变的代谢物侧面的候选人线的快、可靠的鉴定。我们执行了怀有 Arabidopsis 的侧面的机关边界(高球) 领域(LBD )/Asymmetric 象 Leaves2 一样(ASL ) 基因的米饭 ortholog 的 FL cDNA 的一根米饭狐狸 Arabidopsis 线的 metabolomic 和 transcriptomic 分析, At-LBD37/ASL39。调查米饭狐狸 Arabidopsis 线在与氮新陈代谢有关的代谢物的层次显示出突出的变化。象从 Arabidopsis At-LBD37/ASL39-overexpressor 植物的代谢物分析的结果一样的 transcriptomic 数据与这些调查结果一致。而且, Os-LBD37/ASL39-overexpressing 米饭植物的 metabolomic 和 transcriptomic 分析显示 Os-LBD37/ASL39 在米饭与与氮新陈代谢有关的过程被联系。因此,一个基于 metabolomics 的屏蔽方法的联合和一条 gain-of-function 途径为在 Arabidopsis 和米饭的新奇基因的快速的描述是有用的。 | Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko Horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki Saito | 2010 | Molecular Plant2010，3，1： | 15 |
| 3 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 4 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 5 | Deciphering Starch Quality of Rice Kernels Using Metabolite Profiling and Pedigree Network Analysis显示文摘米饭谷物的生理的性质对消费者立即明显。米饭差异研究集合的高范围的 metabolomic 描述预言了在丰满的酸和类脂化合物之间的否定关联层次和直链淀粉 / 总数淀粉比率(直链淀粉比率) ,而是为这的原因是不清楚的。为了在米饭核,淀粉小粒结构,直链淀粉比率,和代谢物的视觉显型之中获得新卓见进关系,变化,我们与各种各样的直链淀粉比率和二猛烈异种调查了五装饰用的梨树栽培变种的代谢物变化( e1 ,淀粉 synthase IIIa ( SSIIIa )缺乏的异种和 SSIIIa/starch 分叉的酶()双大美人异种 4019 )由使用集体 基于spectrometry 的 metabolomics 技术。扫描电子显微镜学清楚地证明二异种有不平常的淀粉小粒结构。,有高直链淀粉比率(Hoshiyutaka 和 Yumetoiro ) 的二栽培变种的 metabolomic 作文展出了类似的模式双大美人异种,它有极其高的直链淀粉比率,不同。栽培变种和异种的瑞斯家谱网络分析在在日本繁殖的米饭提供了卓见进在新陈代谢特点的性质和他们的内在的基因基础之间的协会。多维的可伸缩分析表明 Hoshiyutaka 和 Yumetoiro 栽培变种是象 Indica 一样,然而,他们作为装饰用的梨树 subpopulations 被分类。探索 metabolomic 特点是跟随米饭的一个强大的方法基因踪迹和繁殖历史。 | Miyako Kusano Atsushi Fukushima Naoko Fujita Yozo Okazaki Makoto Kobayashi Naoko Fujita Oitome Kaworu Ebana Kazuki Saito | 2012 | Molecular Plant2012，5，2： | 4 |
| 6 | Intraperitoneal Hyperthermic Perfusion Combined with Surgery Effective for Gastric Cancer Patients with Peritoneal Seeding显示文摘 | SHIGERU FUJIMOTO RAM DHOJ SHRESTHA MASASHI KOKUBUN MASAYASU OHTA MAKOTO TAKAHASHI KOKURIKI KOBAYASHI SOHZABURO KIUCHI KATSUJI OKUI TAKEYOSHI MIYOSHI NOBORU ARIMIZU HIROYOSHI TAKAMIZAWA | 1988 | Annals of Surgery1988，，1： | 2 |
| 7 | 显示出与肝炎 B 病毒感染联系的微分表示的细胞的基因的鉴定显示文摘 AIM: To investigate the impact of hepatitis B virus (HBV) infection on cellular gene expression, by conducting both in vitro and in vivo studies. METHODS: Knockdown of HBV was targeted by stable expression of short hairpin RNA (shRNA) in huH-1 cells. Cellular gene expression was compared using a human 30K cDNA microarray in the cells and quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) (qRT-PCR) in the cells, hepatocellular carcinoma (HCC) and surrounding non-cancerous liver tissues (SL). RESULTS: The expressions of HBsAg and HBx protein were markedly suppressed in the cells and in HBx transgenic mouse liver, respectively, after introduction of shRNA. Of the 30K genes studied, 135 and 103 genes were identified as being down- and up-regulated, respectively, by at least twofold in the knockdown cells. Functional annotation revealed that 85 and 62 genes were classified into four up-regulated and five down-regulated functional categories, respectively. When gene expression levels were compared between HCC and SL, eight candidate genes that were confirmed to be up- or down-regulated in the knockdown cells by both microarray and qRT-PCR analyses were not expressed as expected from HBV reduction in HCC, but had similar expression patterns in HBV- and hepatitis C virus-associated cases. In contrast, among the eight genes, only APM2 was constantly repressed in HBV non-associated tissues irrespective of HCC or SL. | Yasuo Fukuhara Takeshi Suda Makoto Kobayashi Yasushi Tamura Masato Igarashi Nobuo Waguri Hirokazu Kawai Yutaka Aoyagi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 8 | The growth of city systems with high -speed railway systems显示文摘 | Kiyoshi Kobayashi Makoto Okumura | 1997 | Annals of Regional Scienec1997，31，： | 1 |
| 9 | Entire hemithorax irradiation following complete resection in patients with Stage II–III invasive thymoma显示文摘 | Minoru Uematsu Hiroshi Yoshida Makoto Kondo Jun Itami Kazuo Hatano Kouichi Isobe Hisao Ito Kouichi Kobayashi Yutaka Yamaguchi Atsushi Kubo | 1996 | International Journal of Radiation Oncology Biology Physics1996，，2： | 1 |
| 10 | The growth of city systems with high-speed railway systems显示文摘 | KIYOSHI KOBAYASHI MAKOTO OKUMURA | 1997 | The Annals of Regional Science1997，31，1： | 1 |
| 11 | The influence of hepatitis?B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma显示文摘 | Makoto Chuma Shuhei Hige Toshiya Kamiyama Takashi Meguro Atsushi Nagasaka Kazuaki Nakanishi Yoshiya Yamamoto Mitsuru Nakanishi Toshihisa Kohara Takuya Sho Keiko Yamamoto Hiromasa Horimoto Tomoe Kobayashi Hideki Yokoo Michiaki Matsushita Satoru Todo Masahi | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 12 | The Growth of City System with High-speed Railway System显示文摘 | Kiyoshi Kobayashi Makoto Okximura | 1997 | The Annals of Re- gional Science1997，31，01： | 1 |
| 13 | The Growth of City System with High-speed Railway System显示文摘 | Kiyoshi Kobayashi Makoto Okumura | 1997 | The Annals of Regional Science1997，3，1： | 1 |
| 14 | The influence of hepatitis?B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma显示文摘 | Makoto Chuma Shuhei Hige Toshiya Kamiyama Takashi Meguro Atsushi Nagasaka Kazuaki Nakanishi Yoshiya Yamamoto Mitsuru Nakanishi Toshihisa Kohara Takuya Sho Keiko Yamamoto Hiromasa Horimoto Tomoe Kobayashi Hideki Yokoo Michiaki Matsushita Satoru Todo Masahi | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 15 | The Growth of City Systems with High-speed Railway Systems显示文摘 | Kiyoshi Kobayashi Makoto Okmnura | 1997 | The Annals of Regional Science1997，31，1： | 1 |
| 16 | The growth of city systems with high-speed railway systems显示文摘 | Kiyoshi Kobayashi Makoto Okumura | 1997 | The AnnalsofRegionalScience1997，31，1： | 1 |
| 17 | The Growth of City Systems with High-speed Railway Systems 显示文摘 | Kiyoshi Kobayashi Makoto Okmnura | 1997 | The Annals of Regional Science1997，31，1： | 1 |
| 18 | The Growth of City Systems with High Speed Railway Systems显示文摘 | Kiyoshi Kobayashi Makoto Okumura | 1997 | The Annals of Regional Science1997，31，1： | 1 |
| 19 | Alcohol Fermentation of Starch by a Genetic Recombinant Yeast Having Glucoamylase Activity显示文摘 | Yoshitoshi Nakamura Fumihisa Kobayashi Makoto Ohnaga | 1997 | Biotechnology and Bioengineering1997，53，： | 1 |
| 20 | Progressive Disappearance of Anti-Hepatitis B Surface Antigen Antibody and Reverse Seroconversion after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Previous Hepatitis B Virus Infection显示文摘 | Masahiro Onozawa Satoshi Hashino Koh Izumiyama Kaoru Kahata Makoto Chuma Akio Mori Takeshi Kondo Nobuyasu Toyoshima Shuichi Ota Sumiko Kobayashi Shuhei Hige Tomomi Toubai Junji Tanaka Masahiro Imamura Masahiro Asaka | 2005 | Transplantation2005，，5： | 1 |
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