|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 2 | RELIABLE FILE TRANSFER IN GRID ENVIRONMENTS 显示文摘 | Ravi K Madduri | 2002 | Proceedings of the 27th Annual IEEE Conference on Local Computer Networks2002，，： | 1 |
| 3 | Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli显示文摘 | Madduri K Torti F Colombo A L | 1993 | J Bacteriol1993，175，12： | 1 |
| 4 | Production of the antitumor drug epirubicin (4'-epi-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius显示文摘 | Madduri K Kennedy J Rivola G | 1998 | NatBiotechnol1998，16，1： | 1 |
| 5 | Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius显示文摘 | Madduri K Hutchinson C R | 1995 | JBacteriol1995，177，13： | 1 |
| 6 | Genes for the biosynthesis: applications for yield improvement in Saccharopolyspora spinosa显示文摘 | MADDURI K WALDRON C MATSUSHIMA P | 2001 | Journal of Industrial Microbiology and Biotechnology2001，27，： | 1 |
| 7 | Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase显示文摘 | Grimm A Madduri K Ali A | 1994 | Gene1994，151，12： | 1 |
| 8 | A cluster of genes for the biosynthesis of spinosyns, novel macrolide insect 显示文摘 | WALDRON C MADDURI K CRAWFORD K | 2000 | Antonie van Leeuwenhoek2000，78，： | 1 |
| 9 | Designing scalable synthetic compact applications for benchmarking high productivity computing systems显示文摘 | BADER D MADDURI K GILBERT J | 2006 | CTWatch Quarterly2006，4，2： | 1 |
| 10 | Functional characterization and transcriptional analysis of the dnrRl locus,which controls daunorubicin biosynthesis in Streptomyces peucetius显示文摘 | Madduri K Hutchinson CR | 1995 | J Bacteriol1995，177，5： | 1 |
| 11 | Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine显示文摘 | Otten SL Gallo MA Madduri K etal | 1997 | J Bacteriol1997，179，13： | 1 |
| 12 | Genes for the biosynthesis of spinosyns: applications for yield improvement in Saccharopolyspora spinosa显示文摘 | Madduri K Waldron C Matsushima P | 2001 | J Ind Microbiol2001，27，6： | 1 |
| 13 | A Cluster of Genes for the Biosynthesis of Spinosys, Novel Macrolide Insect Control Agents Produced by Saccharopolyspora spinosa显示文摘 | WALDRON C MADDURI K CRAWFORD K et a/ | 2000 | Antonie Van Leeuwenhoek Interanational Journal of General and Molecular Microbiology2000，78，34： | 1 |
| 14 | Collagen nerve conduits releasing the neurotrophic factors GDNF and NGF 显示文摘 | Madduri S Feldman K Tervoort T | 2010 | J Control Release2010，143，2： | 1 |
| 15 | Optimization of Parallel Particle-to Grid Interpolation on Leading Multicore Platforms显示文摘 | MADDURI K SU J WILLIAMS S | 2012 | Parallel and Distributed Systems IEEE Transactions on2012，23，10： | 1 |
| 16 | Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine显示文摘 | Otten SL Gallo MA Madduri K | 1997 | J Bacteriol1997，179，13： | 1 |
| 17 | Production of the antitu- mor drug epirubicin ( 4'-epidoxorubicin ) and its precursor by a genetically engineered strain of Streptomyces peucetius 显示文摘 | Madduri K Kennedy J Rivola G | 1998 | Nat Biotechnol1998，16，1： | 1 |
| 18 | Collagen nerve conduits releasing the neurotrophic factors GDNF and NGF显示文摘 | Madduri S Feldman K Tervoort T | 2010 | J Control Release2010，143，2： | 1 |
| 19 | A graph-theoretic analysis of the hu- man protein-interaction network using multicore parallel algo- rithms显示文摘 | Bader D A Madduri K | 2008 | Parallel Computing2008，34，11： | 1 |
| 20 | Productio of the antitumor drug epirubicin (4'-epidoxorubicir and its precursor by a genetically engineered strai of Streptomyces peucetius显示文摘 | Madduri K Kennedy J Rivola G | 1998 | Natm Biotechnology1998，16，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员