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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | identification of the 72- kDa(MMP - 2)and 92 - kDa(MMP - 9)gelatinase type iv collar - genase in preparations of laminin and Matrigel 显示文摘 | Mackay A R Gomez D E Cottam D W | 1993 | Biotech - niques1993，15，： | 1 |
| 3 | Development of high-manganese steels for heavy duty cast-to-shape applications显示文摘 | SMITH R W DEMONTE A MACKAY W B F | 2004 | J Mater Process Technol2004，153，： | 1 |
| 4 | Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer:a systematic review and practice guideline显示文摘 | Noble J Ellis P M Mackay J A Evans W K | 2006 | J Thorac Oncol2006，1，： | 1 |
| 5 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 6 | Controlled atmosphere storage of rabbiteye blueberries enhances postharvest quality aspects显示文摘 | SCHOTSMANS W MOLAN A MACKAY B | 2007 | Postharvest Biol Technol2007，44，： | 1 |
| 7 | Rate of Evaporation of Low - Solubility Contami- nants from Water Bodis to Atmosphere 显示文摘 | Mackay D Wolkoff A W | 1973 | Environment Science and Technol- ogy1973，，： | 1 |
| 8 | Effect of clarithromycin on muclear factor-kappa B and transforming growth factor beta in chronic rhino- sinusitis显示文摘 | WALLWORK B COMAN W MACKAY SIM A | 2004 | Larygoscope2004，114，： | 1 |
| 9 | Management of unresected stage Ⅲ non - small cell lung cancer: a systematic review显示文摘 | OKAWARA G MACKAY J A EVANS W K | 2006 | J Thorac Oncol2006，1，4： | 1 |
| 10 | Controlled atmosphere storage of rabbiteye blueberries postharvest quality aspects显示文摘 | SCHOTSMANS W MOLAN A MACKAY B | 2007 | Postharvest Biology and Technology2007，44，3： | 1 |
| 11 | Development of high- manganese steels for heavy duty east-to-shape applications 显示文摘 | Smith R W Demonte A Mackay W B F | 2004 | Journal of Materials of Processing Technology2004，，： | 1 |
| 12 | Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides 显示文摘 | BULTE J W KRAITCHMAN D L MACKAY A M | 2004 | Blood2004，104，10： | 1 |
| 13 | Controlled atmosphere storage of rabbiteye blueberries enhances postharvest quality aspects显示文摘 | SCHOTSMANS W MOLAN A MACKAY B | 2007 | Postharvest Biol Technol2007，44，： | 1 |
| 14 | Effect of clarithromycin on nuclear factor-kappa B and transforming growth factor-beta in chronic rhinosinusitis显示文摘 | Wallwork B Coman W Mackay Sim A | 2004 | Laryngoscope2004，114，2： | 1 |
| 15 | Micropropagation of Mexican redbud (Cercis Canadensis 'mexicana ')显示文摘 | Mackay W A Tipton J L Thompson G A | 1995 | Plant Cell Tissue and Organ Culture1995，43，3： | 1 |
| 16 | Two-Photon-Induced Photoisomerization of an Azo Dye显示文摘 | Magennis S W Mackay F S Jones A C | 2005 | J Chem Mater2005，17，8： | 1 |
| 17 | Helicobac- ter Pylori in Children Is Strongly Associated with Poverty显示文摘 | Malcolm C A MacKay W G Shepherd A | 2000 | Scot Med J2000，49，4： | 1 |
| 18 | A simple model to describe the dissolution of phosphate rock in soils 显示文摘 | MacKay A D Syers J K Tillman R W | 1986 | Soil Science Society of America Journal1986，50，29： | 1 |
| 19 | Multilineage potential of adult human mesenchymal stem cells显示文摘 | Pittenger M F Mackay A M Simonetti D W | 1999 | Science1999，284，1135： | 1 |
| 20 | Thiocholesterol-Based Lip- ids for Ordered Assembly of Bioresponsive Gene Carriers 显示文摘 | I-Iuang Z Li W Mackay J A | 2005 | Molecular therapy2005，11，3： | 1 |
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