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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 3 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 4 | Local dynamics in DNA by temperature-dependent stokes shifts of an intercalated dye 显示文摘 | Brauns E B Murphy C J Berg M A | 1998 | J Am Chem Soc1998，120，： | 1 |
| 5 | Mycophenolic acid morphlinoethyester (RS- 61443) is a new immunosupperessant that prevents and halts heart allograft rejection by selective inhibition of T- and B- cell purine synthesis显示文摘 | Hoyt E G Murphy M P | 1990 | Transplantation Proc1990，22，6： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | Increased synovial tissue NF - kappaB1 expression at sites adjaceul to the cartilage - pannus junetion in rheumatoid arthritis显示文摘 | Benito M J Murphy E Murphy EP | 2004 | Arthritis Rheum2004，50，6： | 1 |
| 8 | Time trends in mortality asso- ciated with depression:Findings from the Stirling Count study 显示文摘 | Murphy J M Gilman S E Lesage A | 2010 | Canadian Journal of Psychiatry2010，55，12： | 1 |
| 9 | Reversible converson of nitroxyl anion to nitric oxide by superoxide dismutase显示文摘 | MURPHY M E SIES H | 1991 | Proc Natl Acad Sci USA1991，88，10： | 1 |
| 10 | Thermal Performance of Three Solar Air Heaters 显示文摘 | Parker B F Lindley M R Colliver D G Murphy W E | 1993 | Solar Energy1993，51，6： | 1 |
| 11 | CEA as a monitor of gastrointestinal malignancy显示文摘 | Holyoke E D Che T M Murphy G P | 1975 | Cancer1975，35，： | 1 |
| 12 | Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis显示文摘 | ROONEY T MURPHY E BENITO M | 2004 | Ann Rheum Dis2004，63，11： | 1 |
| 13 | Effect of oatβ-glucan on susceptibility to respiratory infection in aged mice 显示文摘 | Murphy E A Davis J M Brown A S | 2004 | Faseb journal2004，18，4： | 1 |
| 14 | PbTe colloidal nanocrystals: Synthesis, characterization, and multiple exciton generation显示文摘 | Murphy J E Beard M C Norman A G | 2006 | Journal of the American Chemical Society2006，128，10： | 1 |
| 15 | Influence of mineral-bound humic substances on the sorption of hydrophobic organic compounds显示文摘 | Murphy E M Zachara J M Smith S C | 1990 | Environmental Science & Technology1990，24，10： | 1 |
| 16 | ARF,autophagy and tumor suppression显示文摘 | Pimkina J Murphy M E | 2009 | Autophagy2009，5，3： | 1 |
| 17 | Commonage Land and Farmer Up- take of the Rural Environment Protection Scheme in Ireland 显示文摘 | Van Rensburg T M Murphy E Rocks P | 2009 | Land Use Policy2009，26，2： | 1 |
| 18 | Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis显示文摘 | Murphy E Benito M | 2004 | Annals Rheum2004，63，11： | 1 |
| 19 | Bilateral amblyopia after a short period of reverse occlusion in kittens显示文摘 | MURPHY K M MITCHELL D E | 1986 | Nature1986，323，6088： | 1 |
| 20 | Knowledge Management, Emergency Response, and Hurricane Katrina 显示文摘 | Murphy T Jennex M E | 2006 | International Journal of Intelligent Control and Systems2006，11，4： | 1 |
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