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| 1 | Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide显示文摘AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins. | H Yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 2 | Effect of MnS on the heterogeneous nucleation of Cu precipitates in Fe-10 and -5mass% Cu alloys 显示文摘 | Hasegawa H Nakajima K Mizoguchi S | 2003 | ISIJ International2003，43，7： | 1 |
| 3 | The development of Cu bond- ing wire with oxidation-resistant metal coating 显示文摘 | Kaimori S Nonaka T Mizoguchi A | 2006 | IEEE Transaction onAdvanced Packaging2006，29，2： | 1 |
| 4 | Effects of alloying elements on interdendritic microsegregation of carbon steel显示文摘 | UESHIMA Y KOMATSU N MIZOGUCHI S etal | 1987 | Testu-to-Hagane1987，73，11： | 1 |
| 5 | Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria 显示文摘 | Yoshida M Kobayashi K Kuo T T Bry L Glickman J N Claypool S M Kaser A Nagaishi T Higgins D E Mizoguchi E Wakatsuki Y Roopenian D C Mizoguchi A Lencer W I and Blumberg R S | 2006 | The Journal of Clinical Investigation2006，116，： | 1 |
| 6 | Distinct roles of GIGANTEA in Promoting Flowering and Regulating Circadian Rhythms in Arabidopsis显示文摘 | MIZOGUCHI T WRIGHT L FUJIWARA S | 2005 | Plant Cell2005，17，8： | 1 |
| 7 | Arsenic induces apopto sis in B-cell leukamenic cell lines in vitro activation of caspases and down-regulation of bcl-2 protein显示文摘 | 15,Akao Y Mizoguchi H Kojima S | 1998 | Br J Haematal1998，102，4： | 1 |
| 8 | Multiplex real - time PCR for the simultaneous detection of herpessimplex virus, human herpesvirus 6, and human herpesvirus 7 显示文摘 | WADA K MIZOGUCHI S ITO Y | 2009 | Microbiol Immunol2009，53，： | 1 |
| 9 | Magnetic anisotropy from dipolar interactions in amorphous ferrimgnetic alloys 显示文摘 | Mizoguchi T Cargil G S | 1979 | J Appl Phys1979，50，5： | 1 |
| 10 | Extracapsular cataract extraction with a sutureless incision for dense cataracts 显示文摘 | Kimura H Kuroda S Mizoguchi N | 1999 | Cataract Refractive Surgery1999，25，9： | 1 |
| 11 | Polarized os- teoclasts put marks of tartrate-resistant acid phosphatase on dentin slices - a simple method for identifying polar- ized osteoclasts显示文摘 | Nakayama T Mizoguchi T Uehara S | 2011 | Bone2011，49，6： | 1 |
| 12 | The accuracy of is F - fluoro - 2 - deoxy - D - glucose - positron emission tomography/compu- ted tomography, ultrasonography, and enhanced computed tomo- graphy alone in the preoperative diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma显示文摘 | Morita S Mizoguchi K Suzuki M | 2010 | World J Surg2010，34，11： | 1 |
| 13 | Wiskott-Aldrich syn- drome protein-deficient mice reveal a role for WASP in T but not B cell activation 显示文摘 | Snapper S B Rosen F S Mizoguchi E | 1998 | Immunity1998，9，1： | 1 |
| 14 | Very low power consumption Viterbi decoder LSIC emp-loying the SST(scarce state transition) scheme for multimedia mobile communications显示文摘 | SEKI K KUBOTA S MIZOGUCHI M | 1994 | Electron Lett1994，30，8： | 1 |
| 15 | Redox- trig- gered Switching of Helical Chirality of Poly (Pheny- lacetylene)s Beating Riboflavin Pendants显示文摘 | Iida H Mizoguchi T Oh S D | 2010 | Poly- mer Chemistry2010，1，6： | 1 |
| 16 | Magnetic anisotropy from dipolar interactions in amorphous ferrimgnetic alloys显示文摘 | Mizoguchi T Cargil G S | 1979 | J Appl Phys1979，50，5： | 1 |
| 17 | Control of Oxides as Inoculants in Steel显示文摘 | Mizoguchi S | 1990 | CAMP-ISIJ1990，3，： | 1 |
| 18 | Extracapsular cataractextraction with a sutureless incision for dense cataracts显示文摘 | Kimura H Kuroda S Mizoguchi N | 1999 | Cataract Refract Surg1999，25，9： | 1 |
| 19 | Mathematical Analysis of Segregation in Continuously Cast Slab显示文摘 | Matsumiya T Kajoka J Mizoguchi S | 1984 | Transactions of the Iron and Steel Institute of Japan1984，24，： | 1 |
| 20 | Extracapsular cataract extraction with a sutureless incision for dense cataracts 显示文摘 | Kimura H Kuroda S Mizoguchi N Terauchi H Matsumura M Nagata M | 1999 | J Cataract Refract Surg1999，25，9： | 1 |
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