|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Function of longitudinal vs circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling显示文摘We summarize from previous works the functions of circular vs. longitudinal muscle in esophageal peristaltic bolus transport using a mix of experimental data, the conservation laws of mechanics and mathematical modeling. Whereas circular muscle tone generates radial closure pressure to create a local peristaltic closure wave, longitudinal muscle tone has two functions, one physiological with mechanical implications, and one purely mechanical. Each of these functions independently reduces the tension of individual circular muscle fibers to maintain closure as a consequence of shortening of longitudinal muscle locally coordinated with increasing circular muscle tone. The physiological function is deduced by combining basic laws of mechanics with concurrent measurements of intraluminal pressure from manometry, and changes in cross sectional muscle area from endoluminal ultrasound from which local longitudinal shortening (LLS) can be accurately obtained. The purely mechanical function of LLS was discovered from mathematical modeling of peristaltic esophageal transport with the axial wall motion generated by LLS. Physiologically, LLS concentrates circular muscle fibers where closure pressure is highest. However, the mechanical function of LLS is to reduce the level of pressure required to maintain closure. The combined physiological and mechanical consequences of LLS are to reduce circular muscle fiber tension and power by as much as 1/10 what would be requiredfor peristalsis without the longitudinal muscle layer, a tremendous benefit that may explain the existence of longitudinal muscle fiber in the gut. We also review what is understood of the role of longitudinal muscle in esophageal emptying, reflux and pathology. | James G Brasseur Mark A Nicosia Anupam Pal Larry S Miller | 2007 | World Journal of Gastroenterology2007，13，9： | 4 |
| 2 | 蒜臭素和大蒜素可缓解促氧化剂诱导的猪上皮细胞氧化应激和脂多糖刺激的细胞免疫调节功能显示文摘本实验以小肠上皮细胞(IPEC-J2)为模型,旨在评估是否蒜臭素(DADS)和大蒜素(DATS)可缓解氧化应激和内毒素应激。实验采用2×2×2因子设计,处理分别为0或18μM的DADS和DATS,0或100μM过氧化氢应激剂,0或10μg/mL内毒素应激剂(LPS),每个处理8个重复。细胞培养在含有DADS和DATS的培养基中18小时,LPS中6小时,过氧化氢中3小时。RT-PCR方法检测细胞因子白介素IL-8、肿瘤坏死因子TNF-α、紧密连接蛋白Claudin 1、occludin、ZO-1的基因表达量。测定跨上皮电阻值(TEER)、培养液上清中过氧化氢酶和IL-8蛋白的顶端分泌量。实验结果表明,LPS刺激可显著提高IPEC-J2中TNF-α和IL-8的基因表达量(P<0.01),而添加过氧化氢和DADS+DATS无显著差异。DADS+DATS有提高IPEC-J2中ZO-1基因表达量的趋势(P=0.08),DADS+DATS和过氧化氢处理没有影响TEER值,但LPS处理有降低TEER值的趋势(P=0.02)。过氧化氢处理显著降低了细胞过氧化氢酶活性(P<0.01),但DADS+DATS预孵会显著恢复其活性(P<0.01)。LPS处理显著提高IL-8的分泌(P<0.01),但DADS+DATS预孵其分泌量进一步增长(P<0.01)。基于当前研究结果得出,DADS+DATS处理能缓解过氧化氢引起的氧化应激,同时能改变LPS处理的IPEC-J2的IL-8分泌量。 | 王丽 Horn N Miller G Ajuwon KM Adeola O | 2017 | 广东饲料2017，26，11： | 3 |
| 3 | Challenges for fuel cells in transport applications显示文摘 | Chalk S G Miller J F Wagner F W | 2000 | Journal of Power Sources2000，86，： | 2 |
| 4 | Successfully cycling alowpermeability, high - yieldgas - condensatereservoir 显示文摘 | O'Dell H G Miller R N | 1967 | JPT1967，19，1： | 2 |
| 5 | Solidstate low-loss intracavity saturable absorber for Nd:YLF lasers:An A-FPSA显示文摘 | KELLER U MILLER D A B BOYD G D | 1992 | Opt Lett1992，17，7： | 2 |
| 6 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 7 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 8 | The Magical Number Seven Plus or Minus two: Some Limits on our Capacity for Processing Information 显示文摘 | Miller G A | 1956 | Psychological Review1956，63，2： | 1 |
| 9 | The use of the 'lateral canthal sling' in ectropion repair 显示文摘 | TENZEL R R BUFFAM F V MILLER G R | 1977 | Can J Ophthalmol1977，12，3： | 1 |
| 10 | Wetting characteristics of newly developed water-repellent material 显示文摘 | Yamauchi G Miller J D Saito H | 1996 | Colloid and Surface A-Physicochemical and Engineering Aspects1996，116，12： | 1 |
| 11 | What Is the Biological Basis of Consciousness显示文摘 | Miller G | 2005 | Science2005，309，： | 1 |
| 12 | Supplemental microbial phytase improves bioavailability of dietary zinc to weanling pigs显示文摘 | kupk Miller E R ullrey D I Yokoyama M T | 1993 | Nutrition1993，，123： | 1 |
| 13 | Preclinical Assessment to Hypocrellin B and Hypocrellin B Derivatives as Sensitizers for Photodymic Therapy of Cancer:Progress Update显示文摘 | Brown K Ballangrud A Metal | 1997 | Photochemistry and Photobiology1997，65，4： | 1 |
| 14 | Micro-Spatial variability of soil nitrate following nitrogen fertilization and drip irrigation 显示文摘 | Zhang R D Vance G F Miller S D | 1999 | Water Air and Soil Pollution1999，116，： | 1 |
| 15 | Review of limit loads of structures containing defects显示文摘 | Miller A G | 1988 | International Journal of Pressure Vessel and Piping1988，32，： | 1 |
| 16 | Gene-environment interaction for the ERCC2 polymorphisms and cmnulative cigarette smoking exposure in lung cancer显示文摘 | Zhon W Lin G Miller DP | 2002 | Cancer Res2002，62，5： | 1 |
| 17 | Use of dinitrosalicylic acid reagent for de- termination of reducing sugar显示文摘 | MILLER G L | 1959 | Anal Chem1959，31，3： | 1 |
| 18 | Sequence,transoriptien and translation of a late gene of the Autographa californica nuclear polyhedrosis virus encoding a 3418K polypeptide显示文摘 | WU J G MILLER L K | 1989 | J Gen Virol1989，70，： | 1 |
| 19 | Microbial ex- pression in soil:methods, applications and challenges 显示文摘 | Saleh L S Miller M Campbell R G | 2005 | Microbiol Methods2005，63，： | 1 |
| 20 | Etiology of small bowel obstruction 显示文摘 | MILLER G BOMAN J SHRIER I | 2000 | Am J Surg2000，180，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员