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| 1 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 2 | Detection of cerebral hypoperfusion during trial carotid occlusion with reversal following extracranialintracranial bypass prior to permanent occlusion显示文摘 | Walker BS Mathews D Batjer H | 1994 | Clin Nucl Med1994，19，： | 1 |
| 3 | Dynalign: an algorithmfor finding the secondary structure common to two RNA se-quences 显示文摘 | MATHEWS D H TURNER D H | 2002 | J Mol Biol2002，317，2： | 1 |
| 4 | Type B responseregulators of Arabidopsis play key roles in cytokinin signaling and plant de-velopment显示文摘 | ARGYROS R D MATHEWS D E CHIANG Y H | 2008 | Plant Cell2008，20，： | 1 |
| 5 | Deter- mining embedding dimension for phase-space recon- struction using a geometrical construction显示文摘 | Kennel Mathew B Brown R Abarbanel H D I | 1992 | Phy Rev A1992，45，： | 1 |
| 6 | Complex cooperate microcapsules for mammalian cell culture and artificial rogan development显示文摘 | Mathew H W Salley S O Peterson W D | 1993 | Biotechnol Prog1993，9，： | 1 |
| 7 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | Mathews D H Sabina J Zuker M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 8 | Incorporating chemi- cal modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure 显示文摘 | Mathews D H Disney M D Childs J L | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，19： | 1 |
| 9 | Type B response regulators of Arabidopsis play key roles in cyto- kinin signaling and plant development 显示文摘 | Argyros R D Mathews D E Chiang Y H | 2008 | The Plant Cell2008，20，8： | 1 |
| 10 | Determining embedding dimension for phase-space reconstruction using a geometrical construction 显示文摘 | Kennel Mathew B Brown R Abarbanel H D I | 1992 | Phy Rev A1992，45，： | 1 |
| 11 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 12 | RNAstructure:software for RNA secondary structure prediction and analysis显示文摘 | Reuter J S Mathews D H | | 0，，： | 1 |
| 13 | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure 显示文摘 | Mathews D H Disney M D Childs J L | 2004 | Proceedings of the National Academy of Sciences2004，101，19： | 1 |
| 14 | Adhesion Tests for Bituminous Materials 显示文摘 | Mathew D H | 1965 | Journal of Chemical Technology & Biotechnology1965，15，9： | 1 |
| 15 | Determining Embedding Dimension for Phase-Space Reconstruction Using a Geometrical Construction 显示文摘 | Kennel Mathew B Brown R Abarbanel H D I | 1992 | Phy Rev A1992，45，： | 1 |
| 16 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 17 | Determining Embedding Dimension for Phase-Space Reconstruction Using a Geometrical Construction 显示文摘 | Kennel Mathew B Brown R Abarbanel H D I | 1992 | Phy Rev A1992，45，： | 1 |
| 18 | In situ infrared charac- terization during atomic layer deposition of lanthanum oxide显示文摘 | Jinhee K Min D Mathew D H | 2009 | Journal of Physical Chemistry C2009，113，： | 1 |
| 19 | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure显示文摘 | MATHEWS D H D CHILDS M D SCHROEDER J L | 2004 | Proc Natl Acad Sci USA2004，101，2： | 1 |
| 20 | Growth inhibition of Candida albicans hyphae by CD8^+ lymphocytes显示文摘 | BENO D W STOVER A G MATHEWS H L | 1995 | J Immunol1995，54，10： | 1 |
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