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| 1 | Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis显示文摘The leucine-rich repeats and PDZ (LAP) family of genes are crucial for the maintenance of cell polarity as well as for epithelial homeostasis and tumor suppression in both vertebrates and invertebrates.Four members of this gene family are known:densin,erbin,scribble and lano.Here,we identified the four members of the LAP gene family in Xenopus tropicalis and studied their expression patterns during embryonic development.The Xenopus LAP proteins show a conserved domain structure that is similar to their homologs in other vertebrates.In Xenopus embryos,these genes were detected in animal cap cells at the early gastrula stage.At later stages of development,they were widely expressed in epithelial tissues that are highly polar in nature,including the neural epithelia,optic and otic vesicles,and in the pronephros.These data suggest that the roles of the Xenopus LAP genes in the control of cell polarity and morphogenesis are conserved during early development.Erbin and lano show similar expression patterns in the developing head,suggesting potential functional interactions between the two molecules in vivo. | YANG QiuTan LV XiaoYan KONG QingHua LI ChaoCui ZHOU Qin MAO BingYu | 2011 | Science China(Life Sciences)2011，54，10： | 3 |
| 2 | Characterization of the immune defense related tissues,cells,and genes in amphioxus显示文摘Amphioxus is an important animal model for phylogenetic analysis,including comparative immunology.Exploring the immune system in amphioxus contributes to our understanding of the origin and evolution of the vertebrate immune system.We investigated the amphioxus immune system using ultrastructural examination and in situ hybridization.The expression patterns of TLR1(toll-like receptor 1),C1Q(complement component 1,q subcomponent),ECSIT(evolutionarily conserved signaling intermediate in Toll pathways),SoxC,DDAHa(Dimethylarginine dimethylaminohydrolase a),and NOS(nitric oxide synthase) show that these genes play key roles in amphioxus immunity.Our results suggest that the epidermis and alimentary canal epithelium may play important roles in immune defense,while macrophages located in the coelom and so-called lymph spaces may also be crucial immune cells. | LIN YuShuang CHEN DongYan ZHANG Wei CAI ZhaoPing CHEN ZhongKe ZHANG Ning MAO BingYu ZHANG HongWei | 2011 | Science China(Life Sciences)2011，54，11： | 2 |
| 3 | Origin of new genes after zygotic genome activation in vertebrate显示文摘 | Hai-Bo Xu Yong-Xin Li Yan Li Newton O. Otecko Ya-Ping Zhang Bingyu Mao Dong-Dong Wu | 2018 | Journal of Molecular Cell Biology2018，10，2： | 1 |
| 4 | Cloning and developmental expression of the Xenopus Nkx6 genes显示文摘 | Shuhua Zhao Huifeng Jiang Wen Wang Bingyu Mao | | 0，2007，： | 1 |
| 5 | Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults显示文摘Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change in immune phenotype is a key indication of the diseased or healthy status.However,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed.Here,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known diseases.Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals.The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis.Our initial analysis and machine modelling prediction showed that na.ve T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T cells.This is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and sex.The age of a person's immune system might be different from their chronological age.Our immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction.Our research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice. | Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin | 2023 | Phenomics2023，3，4： | 1 |
| 6 | Embryonic expression and evolutionary analysis of the amphioxus Dickkopf and Kremen family genes显示文摘The secreted Wnt signaling inhibitor Dickkopf1 (Dkk1) plays key role in vertebrate head induction. Its receptor Kremen synergizes with Dkk1 in Wnt inhibition. Here we have carried out expression and functional studies of the Dkk and Kremen genes in amphioxus (Branchiostoma belcheri). During embryonic and larval development, BbDkk1/2/4 is expressed in the posterior mesoendoderm, anterior somatic mesoderm and the pharyngeal regions. Its expression becomes restricted to the pharyngeal region on the left side at larval stages. In 45 h larvae, BbDkk1/2/4 is expressed specifically in the cerebral vesicle. BbDkk3 was only detected at larval stages in the mid-intestine region. Seven Kremen related genes were identified in the genome of the Florida amphioxus (Branchiostoma floridae), clustered in 4 scaffolds, and are designated Kremen1-4 and Kremen-like 1-3, respectively. In B. belcheri, Kremen1 is strongly expressed in the mesoen-doderm during early development and Kremen3 is expressed asymmetrically in spots in the larval pharyngeal region. In luciferase reporter assays, BbDkk1/2/4 can strongly inhibit Wnt signaling, while BbDkk3, BbKremen1 and BbKremen3 can not. No co-operative effect was observed between amphioxus Dkk1/2/4 and Kremens, suggesting that the interaction between Dkk and Kremen likely origi-nated later during evolution. | Yujun Zhang Bingyu Mao | 2010 | Journal of Genetics and Genomics2010，37，9： | 1 |
| 7 | ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling显示文摘ZC4H2 encodes a C4H2 type zinc-finger nuclear factor,the mutation of which has been associated with disorders with various clinical phenotypes in human,including developmental delay,intellectual disability and dystonia.ZC4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220,an ubiquitin E3 ligase involved in Gli signaling.Here we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish,with mispatterned progenitor and neuronal domains in the ventral spinal cord.We showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in vivo.Our data provides new insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes. | Pengcheng Ma Ning-Ning Song Xiaoning Cheng Liang Zhu Qiong Zhang Long long Zhang Xiangcai Yang Huishan Wang Qinghua Kong Deli Shi Yu-Qiang Ding Bingyu Mao | 2020 | Journal of Molecular Cell Biology2020，12，5： | 1 |
| 8 | Single-cell RNA Sequencing Reveals Thoracolumbar Vertebra Heterogeneity and Rib-genesis in Pigs显示文摘Development of thoracolumbar vertebra(TLV)and rib primordium(RP)is a common evolutionary feature across vertebrates,although whole-organism analysis of the expression dynamics of TLV-and RP-related genes has been lacking.Here,we investigated the single-cell transcriptome landscape of thoracic vertebra(TV),lumbar vertebra(LV),and RP cells from a pig embryo at 27 days post-fertilization(dpf)and identified six cell types with distinct gene expression signatures.In-depth dissection of the gene expression dynamics and RNA velocity revealed a coupled process of osteogenesis and angiogenesis during TLV and RP development.Further analysis of cell type-specific and strand-specific expression uncovered the extremely high level of HOXA103′-UTR sequence specific to osteoblasts of LV cells,which may function as anti-HOXA10-antisense by counteracting the HOXA10-antisense effect to determine TLV transition.Thus,this work provides a valuable resource for understanding embryonic osteogenesis and angiogenesis underlying vertebrate TLV and RP development at the cell type-specific resolution,which serves as a comprehensive view on the transcriptional profile of animal embryo development. | Jianbo Li Ligang Wang Dawei Yu Junfeng Hao Longchao Zhang Adeniyi C.Adeola Bingyu Mao Yun Gao Shifang Wu Chunling Zhu Yongqing Zhang Jilong Ren Changgai Mu David M.Irwin Lixian Wang Tang Hai Haibing Xie Yaping Zhang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 1 |
| 9 | Mophological and functional studies on the epidermal cells of amphioxus at different developmental stages显示文摘 | Mao Bingyu Sun Xiaoyang Zhang Hongwei | 1997 | Chin J Oceanol Limnol1997，15，3： | 1 |
| 10 | Kremen proteins areDickkopf receptors that regulate Wnt/beta-catenin signalling显示文摘 | Bingyu Mao Wei Wu Gary Davidson | 2002 | Natu-re2002，417，： | 1 |
| 11 | More or less is fine:an undercover work of DKK1 in anthrax toxin uptake显示文摘The protective antigen(PA)mediated internalization of the anthrax complexes is critical in the development of anthrax,which depends on specific membrane receptors,namely ANTXR1(also known as TEM8)and ANTXR2(also known as CMG2)[1].In a screen for host proteins required for anthrax toxin action,low-density lipoprotein receptor-related protein 6(LRP6)was found important for efficient toxin entry in human M2182 prostate carcinoma cells[2],which interacts with both ANTXR1 and ANTXR2.However,the role of LRP6 in anthrax toxicity remains controversial as both in mice and in human HeLa cells,knockout or knockdown of LRP6 has no clear effect on their sensitivity to anthrax toxins[3]. | MAO BingYu WU Wei | 2014 | Science China(Life Sciences)2014，57，7： | 0 |
| 12 | Involvement of XZFP36L1, an RNA-binding protein, in Xenopus neural development '显示文摘 | Yingjie XIA Shuhua ZHAO Bingyu MAO | 2012 | Zoological Research2012，33，6： | 0 |
| 13 | Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression显示文摘Sonic hedgehog (Shh) signaling is essential for the proliferation of cerebellar granule neuron progenitors (CGNPs), and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma (MB). During vertebrate neural development, RNF220, a ubiquitin E3 ligase, is involved in spinal cord patterning by modulating the subcellular location of glioma-associated oncogene homologs (Glis) through ubiquitination. RNF220 is also required for full activation of Shh signaling during cerebellum development in an epigenetic manner through targeting embryonic ectoderm development. ZC4H2 was reported to be involved in spinal cord patterning by acting as an RNF220 stabilizer. Here, we provided evidence to show that ZC4H2 is also required for full activation of Shh signaling in CGNP and MB progression by stabilizing RNF220. In addition, we found that the ubiquitin E3 ligase RING finger LIM domain-binding protein (RLIM) is responsible for ZC4H2 stabilization via direct ubiquitination, through which RNF220 is also thus stabilized. RLIM is a direct target of Shh signaling and is also required for full activation of Shh signaling in CGNP and MB cell proliferation. We further provided clinical evidence to show that the RLIM‒ZC4H2‒RNF220 cascade is involved in Shh-group MB progression. Disease-causative human RLIM and ZC4H2 mutations affect their interaction and regulation. Therefore, our study sheds light on the regulation of Shh signaling during cerebellar development and MB progression and provides insights into neural disorders caused by RLIM or ZC4H2 mutations. | Yuwei Li Chencheng Yang Huishan Wang Ling Zhao Qinghua Kong Yu Cang Shuhua Zhao Longbao Lv Yan Li Bingyu Mao Pengcheng Ma | 2022 | Journal of Molecular Cell Biology2022，14，1： | 0 |
| 14 | A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication显示文摘The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves.Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory,such as long-term potentiation and long-term depression.In this study,we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types,cell lineage and molecular features.Using the transcriptomes of 105057 nuclei from the hippocampus of a Beagle dog,we identified 26 cell clusters and a putative trajectory of oligodendrocyte development.Comparative analysis revealed a significant convergence between dog differentially expressed genes(DEGs)and putative positively selected genes(PSGs).Forty putative PSGs were DEGs in glutamatergic neurons,especially in Cluster 14,which is related to the regulation of nervous system development.In summary,this study provides a blueprint to understand the cellular mechanism of dog domestication. | Qi-Jun Zhou Xingyan Liu Longlong Zhang Rong Wang Tingting Yin Xiaolu Li Guimei Li Yuqi He Zhaoli Ding Pengcheng Ma Shi-Zhi Wang Bingyu Mao Shihua Zhang Guo-Dong Wang | 2022 | National Science Review2022，9，11： | 0 |
| 15 | Haploinsufficiency oftheTDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse显示文摘TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis(ALS)cases,suggesting a central pathogenic role of this regulatory protein.Clarifying the molecular mechanism controlling TDP43 stability and subcellular location might provide important insights into ALS therapy.The ubiquitin E3 ligase RNF220 is involved in different neural developmental processes through various molecular targets in the mouse.Here,we report that the RNF2207 mice showed progressively decreasing mobility to different extents,some of which developed typical ALS pathological characteristics in spinal motor neurons,including TDP43 cytoplasmic accumulation,atrocytosis,muscle denervation,and atrophy.Mechanistically,RNF220 interacts with TDP43 in vitro and in vivo and promotes its polyubiquitination and proteasomal degradation.In conclusion,we propose that RNF220 might be a modifier of TDP43 function in vivo and contribute to TDP43 pathology in neurodegenerative disease like ALS. | Pengcheng Ma Yuwei Li Huishan Wang Bingyu Mao | 2021 | Journal of Molecular Cell Biology2021，13，5： | 0 |
| 16 | Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes显示文摘中央神经系统(CNS ) 的进化在从无脊椎动物的转变期间是最惹人注目的变化之一到脊椎动物。作为基因新奇的主要来源,基因复制可能在脊椎动物 CNS 的功能的革新起一个重要作用。在这研究,我们集中了于在早脊椎动物进化期间复制了的一组偏导 CNS 的基因。我们在脊椎动物 Xenopus laevis 和头索动物 Brachiostoma belcheri 的胚胎的发展期间调查了 33 个副本基因家庭和他们的 orthologs 的速度空间的表示模式。几乎所有识别副本基因是在 Xenopus 胚胎在 CNS 表示的差别,并且分别地,超过 50% 和 30% 副本基因在 telencephalon 和中间脑的最后部的边界被表示它主要在脊椎动物 CNS 被看作二革新。有趣地,超过 50% 文昌鱼 orthologs 不在检测了由的文昌鱼胚胎在 CNS 显示出明显的表示在 situ 杂交,显示脊椎动物的那一些偏导 CNS 的副本基因可能在无脊椎动物从 non-CNS 基因产生。我们的数据在脊椎动物的 CNS 进化加重基因复制的功能的贡献并且揭开为某脊椎动物的无脊椎的 non-CNS 历史偏导 CNS 的副本基因。 | Yuan Chen Yun Ding ZumingZhang Wen Wang Jun-Yuan Chen Naoto Ueno Bingyu Mao | 2011 | Journal of Genetics and Genomics2011，38，12： | 0 |
| 17 | Foreword显示文摘The State Key Laboratory of Genetic Resources and Evolution,located at the Kunming Institute of Zoology,Chinese Academy of Sciences(CAS),is a leading research center in genetic resource conservation and evolutionary biology.In this special issue of Zoological Research on“Animal Genetic diversity,development and evolution”,we have compiled 12 review and research articles from the Key Lab as well as 4 related articles from external authors,covering,among other topics,genetic biodiversity,molecular phylogeny,evolution of gene families,and the use of mitochondrial DNA in the study of adaptive evolution and tumor evolution. | Bingyu MAO | 2012 | Zoological Research2012，33，S03： | 0 |
| 18 | Involvement of XZFP36L1,an RNA-binding protein,in Xenopus neural development显示文摘Xenopus ZFP36L1(zinc finger protein 36,C3H type-like 1)belongs to the ZFP36 family of RNA-binding proteins,which contains two characteristic tandem CCCH-type zinc-finger domains.The ZFP36 proteins can bind AU-rich elements in 3'untranslated regions of target mRNAs and promote their turnover.However,the expression and role of ZFP36 genes during neural development in Xenopus embryos remains largely unknown.The present study showed that Xenopus ZFP36L1 was expressed at the dorsal part of the forebrain,forebrain-midbrain boundary,and midbrain-hindbrain boundary from late neurula stages to tadpole stages of embryonic development.Overexpression of XZFP36L1 in Xenopus embryos inhibited neural induction and differentiation,leading to severe neural tube defects.The function of XZP36L1 requires both its zinc finger and C terminal domains,which also affect its subcellular localization.These results suggest that XZFP36L1 is likely involved in neural development in Xenopus and might play an important role in post-transcriptional regulation. | Yingjie XIA Shuhua ZHAO Bingyu MAO | 2012 | Zoological Research2012，33，S03： | 0 |
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