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14篇 您的检索式：作者名="MAIELLO M R"

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		题名	作者	年代	出处	被引量
	1	一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.	Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P	2014	中华神经外科疾病研究杂志2014，13，5：	6
	2	EGFR and MEK blockade in tri- ple negative breast cancer ceils 显示文摘	MAIELLO M R D'ALESSIO A	2015	J Cell Biochem2015，116，12：	1
	3	Evaluation of cytotoxic concentration-time response in A549 cells exposed to respirable α-quartz显示文摘	FANIZZA C FRESEGNA A M MAIELLO R	2009	J Appl Toxicol2009，29，：	1
	4	Fetal lung lesions diagnosis:the crucial role of ultrasonography显示文摘	Pedata R Palermo M Maiello M	2009	J Prenat Med2009，3，4：	1
	5	Epidermal growth factor receptor tyrosine kinase inhibitors (EG- FR-TKIs) : simple drugs with a complex mechanism of action显示文摘	Normanno N Maiello M R De Luca A	2003	J''Cell Physiol2003，194，：	1
	6	The RAS/RAF/MEK/ ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches 显示文摘	De Luca A Maiello M R D'Alessio A	2012	Expert Opin Ther Targets2012，16，：	1
	7	Fetal lung lesions diagnosis:the crucial role of ultrasonography显示文摘	Pedata R Palermo M Maiello M		0，，4：	1
	8	The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib显示文摘	NORMANNO N DE LUCA A MAIELLO M R	2006	J Cell Physiol2006，207，2：	1
	9	Breast cancer ceils with acquired resistance to the EGFR tyrosine kinase inhibitor gefitinib show persistent activation of MAPK signal 显示文摘	NORMANNO N CAMPIGLIO M MAIELLO M R	2008	Breast Cancer Res Treat2008，112，1：	1
	10	Breast cancer cells with acquired resistance to the EGFR tyrosine kinase inhibitor gefitinib show persistent activation of MAPK signaling 显示文摘	NORMANNO N CAMPIGLIO M MAIELLO M R	2008	Breast Cancer Res Treat2008，112，1：	1
	11	The MEK/ MAPK pathway is involved in the resistance of breast cancer ceils to the EGFR tyrosine kinase inhibitor gefitinib显示文摘	NORMANNO N DE LUCA A MAIELLO M R	2006	J Cell Physiol2006，207，2：	1
	12	The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways:role in cancer pathogenesis and implications for therapeutic approaches显示文摘	De Luca A Maiello M R D'Alessio A	2012	Expert Opin Ther Targets2012，16，2：	1
	13	The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways:role in Cancer patho-genesis and implications for therapeutic approaches显示文摘	De Luca A Maiello M R D'alessio A	2012	Expert Opin Ther Targets2012，16，2：	1
	14	The RAS/RAF/ MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches 显示文摘	De Luca A Maiello M R D'Alessio A	2012	Ex- pert Opin Ther Targets2012，2，：	1

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