|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Modeling of grout crack of rockbolt grouted system显示文摘This paper presents a numerical study on the pullout behavior of the rockbolt grouted system. Among the complicated failure modes of the rockbolt grouted system, the crack of the grout is concerned here. A trilinear cohesive zone model(CZM) is used to simulate the interfacial behavior of rockbolt–grout interface;and a plastic damaged model is adopted for the grout materials. The feasibility of the numerical method is verified by comparing the calculated results with the test observations. The numerical results indicate that two types of cracks of the grout materials can be identified as the inclined crack and the horizontal crack. The inclined crack forms firstly and then the horizontal crack. Both cracks can reduce the interfacial shear stress and thus reduce the load transfer efficiency. Further analysis indicates that the crack of the gout material can induce the obvious drops of load capacity, which is not a safe failure mode. This study leads to a better understanding of the mechanism for rockbolt grouted system. | Zhu Changxing Chang Xu Men Youdong Luo Xulin | 2015 | International Journal of Mining Science and Technology2015，25，1： | 2 |
| 2 | Analysis of circular concrete-filled steel tube(CFT)support in high ground stress conditions显示文摘 | CHANG Xu LUO Xulin ZHU Changxing | 2014 | Tunnelling and Underground Space Technology2014，43，： | 1 |
| 3 | HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19显示文摘Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a major pathological feature of Coronavirus Disease 2019(COVID-19)and a crucial determinant in COVID-19 prognosis.Understanding the mechanism underlying the SARS-CoV-2-induced cytokine storm is critical for COVID-19 control.Here,we identify that SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α(HIF-1α)play key roles in the virus infection and pro-inflammatory responses. | Mingfu Tian Weiyong Liu Xiang Li Peiyi Zhao Muhammad Adnan Shereen Chengliang Zhu Shanyu Huang Siyu Liu Xiao Yu Miaomiao Yue Pan Pan Wenbiao Wang Yongkui Li Xulin Chen Kailang Wu Zhen Luo Qiwei Zhang Jianguo Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 4 | A-nalysis of circular concrete-filled steel tube(CFT) support in high ground stress conditions显示文摘 | XU Chang LUO Xulin ZHU Changxing | 2014 | Tunnel- ling and Underground Space Technology2014，43，： | 1 |
| 5 | Analysis of circular concrete-filled steel tube (CFT) support in high ground stress conditions显示文摘 | Xu Chang Xulin Luo Changxing Zhu Chunan Tang | 2014 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2014，，： | 1 |
| 6 | SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication显示文摘Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe disease.However,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus transmission.Studying how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its infection.Here,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N protein.We found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’t.Further study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and mice.Mechanistically,N protein specifically interacted with anti-apoptotic protein MCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of MCL-1,which stabilized this protein and promoted it to hijack Bak in mitochondria.Importantly,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a MCL-1 specific inhibitor,S63845.Altogether,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral replication.These may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other viruses.We anticipate that abrogating the N/MCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses. | Pan Pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu Miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang Pin Wan Mingfu Tian Yang Yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 7 | Planning Strategy of Tourism Service Towns under the Land and Space Planning System:A Case Study of Taiping Town in Nanchang City显示文摘In May 2019,the construction of the land and space planning system was officially launched.The Ministry of Natural Resources of the State Council issued the Notice on Comprehensively Implementing Land and Space Planning,which clearly requires all regions to comprehensively launch the land and space planning and puts forward specific work requirements[1].Later,in order to guide the preparation and implementation of land and space planning,various technical standards were successively issued.The dual-assessment technical guidelines,land use classification standards,and the compilation guidelines for provincial,city and county planning were gradually submitted for review and trial implementation.In this context,there have been more and more planning theories and practical studies based on the background of land and space planning.For tourist service towns,how to protect the style and features of the towns under the land and space planning system and preserve the local characteristics is a problem that needs to be solved urgently[2]. | Xulin LIU Qi LUO | 2020 | Asian Agricultural Research2020，12，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员