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| 1 | Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors显示文摘The recent discovery of immune checkpoints inhibitors, especially anti-programmed cell death protein 1(PD-1)and anti-programmed cell death protein ligand 1(PD-L1) monoclonal antibodies, has opened new scenarios in the management of non-small cell lung cancer(NSCLC) and this new class of drugs has achieved a rapid development in the treatment of this disease. However, considering the costs of these drugs and the fact that only a subset of patients experience long-term disease control, the identification of predictive biomarkers for the selection of candidates suitable for treatment has become a priority. The research focused mainly on the expression of the PD-L1 receptor on both tumor cells and/or immune infiltrates determined by immunohistochemistry(IHC). However, different checkpoint inhibitors were tested, different IHC assays were used, different targets were considered(tumor cells, immune infiltrates or both) and different expression thresholds were employed in clinical trials. In some trials the assay was used prospectively to select the patients, while in other trials it was evaluated retrospectively. Some confusion emerges, which makes it difficult to easily compare the literature data and to translate them in practice management. This mini-review shows the possibilities and pitfalls of the PD-L1 expression to predict the activity and efficacy of anti PD1/PD-L1 monoclonal antibodies in the treatment of NSCLC. | Carmelo Tibaldi Alice Lunghi Editta Baldini | 2017 | World Journal of Clinical Oncology2017，8，4： | 8 |
| 2 | Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts 显示文摘 | Lunghi PA Tabilio PP Dall' Aglio | 2003 | Leukemia2003，17，9： | 1 |
| 3 | Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice显示文摘 | Martorana PA Lunghi B Lucattelli M | 2008 | BMC Pulm Med2008，8，： | 1 |
| 4 | Electric power generation from landfill gas using traditional and innovative technologies显示文摘 | BOVE R LUNGHI P | 2006 | Energy Conversion and Management2006，，47： | 1 |
| 5 | Cerebral watenshed hypoperfusion in subarachnoid hemorrhage:computed tomography perfusion analysis显示文摘 | Lantema LA Lunghi A Martchenko S | 2010 | J Neurosurg2010，17，： | 1 |
| 6 | Advanced kinetics based simulation of time to maximum rate under adiabatic eon- ditions显示文摘 | Roduit B Dermaut W Lunghi A | 2008 | Journal of Thermal Analysis and Calorimetry2008，93，1： | 1 |
| 7 | Control of human trophoblast function显示文摘 | Lunghi L Ferretti ME Medici S | 2007 | Reprod Biol Endocrinol2007，5，： | 1 |
| 8 | cAMP efflux from human trophoblast cell lines:a role for multidrug resistance protein (MRP) 1 transporter显示文摘 | Biondi C Ferretti ME Lunghi L | | 0，，： | 1 |
| 9 | Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma:a possible mechanism for its antitumor effect显示文摘 | Corso A Ferretti E Lunghi M | 2005 | Cancer2005，104，1： | 1 |
| 10 | Sine gating detector with simple filtering for low-noise infra-red single photon detection at room temperature 显示文摘 | Nino Walenta Tommaso Lunghi Olivier Guinnard | 2012 | J Applied Physics2012，112，06： | 1 |
| 11 | Highly efficient electricity through a hybrid molten carbonate fuel cell-closed loop gas turbine plant显示文摘 | Piero Lunghi Stefano Ubertini Umberto desideri | 2001 | Energy Conversion and Management2001，，42： | 1 |
| 12 | The impact of hepatitis C virus infection on survival in dialysis patients: meta-analysis of observational studies 显示文摘 | Fabrizi F Takkouche B Lunghi G | 2007 | J Viral Hepat2007，14，10： | 1 |
| 13 | Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: a possible mechanism for its antitumor effect显示文摘 | Corso A Ferretti E Lunghi M | 2005 | Cancer2005，104，1： | 1 |
| 14 | Hepatitis B virus infection in hemodialysis:recent discoveries显示文摘 | Fabrizi F Lunghi G Martin P | 2002 | J Nephrol2002，15，5： | 1 |
| 15 | Assessment of an ambient pressure MCFC:External heated GT hybrid plant with steam injection and post-combustion显示文摘 | Ubertini S Lunghi P | 2001 | Fuel Cellls2001，1，34： | 1 |
| 16 | Outcome of therapy- related myeloid neoplasms treated with azacitidine 显示文摘 | Fianchi L Criscuolo M Lunghi M | 2012 | J HematolOncol2012，5，： | 1 |
| 17 | Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma -induced angiogenesis显示文摘 | Giuliani N Lunghi P Morandi F | 2004 | Leukemia2004，18，3： | 1 |
| 18 | The impact of hepatitis Cvires infection on survival in dialysis patients: recta-analysis of observational studies 显示文摘 | Fabrizi F Takkouche B Lunghi G | 2007 | J Viral Hepat2007，14，10： | 1 |
| 19 | Highly efficient electricity through a hybrid molten carbonate fuel cell-closed loop gas turbine plant显示文摘 | Piero Lunghi Stefano Ubertini Umberto desideri | 2001 | Energy Conversion and Management2001，42，： | 1 |
| 20 | Control of human trophoblast function 显示文摘 | Lunghi L Ferretti ME Medici S | 2007 | Reprod Biol Endocrinol2007，5，： | 1 |
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