|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metabolic aspects of adult patients with nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is a major cause of chronic liver disease and it encompasses a spectrum from simple steatosis to steatohepatitis, fibrosis, or cirrhosis. The mechanisms involved in the occurrence of NAFLD and its progression are probably due to a metabolic profile expressed within the context of a genetic predisposition and is associated with a higher energy intake. The metabolic syndrome(MS) is a cluster of metabolic alterations associated with an increased risk for the development of cardiovascular diseases and diabetes. NAFLD patients have more than one feature of the MS, and now they are considered the hepatic components of the MS. Several scientific advances in understanding the association between NAFLD and MS have identified insulin resistance(IR) as the key aspect in the pathophysiology of both diseases. In the multi parallel hits theory of NAFLD pathogenesis, IR was described to be central in the predisposition of hepatocytes to be susceptible to other multiple pathogenetic factors. The recent knowledge gained from these advances can be applied clinically in the prevention and management of NAFLD and its associated metabolic changes. The present review analyses the current literature and highlights the new evidence on the metabolic aspects in the adult patients with NAFLD. | Ludovico Abenavoli Natasa Milic Laura Di Renzo Tomislav Preveden Milica Medi?-Stojanoska Antonino De Lorenzo | 2016 | World Journal of Gastroenterology2016，22，31： | 17 |
| 2 | Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease显示文摘AIM To determine the clinical effectiveness of nutritional counseling on reduction of non-alcoholic fatty liver disease(NAFLD) severity, weight loss, metabolic and anthropometric indexes and liver enzymes.METHODS Forty-six adults with NAFLD received a 6-mo clinical and a dietary intervention(based on Mediterranean diet) carried out respectively by a gastroenterologist and a nutritionist with counseling license. The counseling process consisted of monthly meeting(about 45 min each). The effect of the treatment was evaluated monitoring liver enzymes, metabolic parameters, cardiovascular risk indexes, NAFLD severity [assessed by ultrasound(US)] and related indexes. All parameters were assessed at baseline. Biochemistry was also assessed at mid-and end-interventions and US was repeated at end-intervention.RESULTS The percentage of patients with steatosis grade equal or higher than 2 was reduced from 93% to 48% and steatosis regressed in 9 patients(20%). At the end of the treatment the end-point concerning the weight(i.e., a 7% weight reduction or achievement/maintenance of normal weight) was accomplished by 25 out of 46 patients(i.e., 54.3%). As far as the liver enzymes is concerned, all three liver enzymes significantly decrease during the treatment the normalization was particularly evident for the ALT enzyme(altered values reduced from 67% down to 11%). Several parameters, i.e., BMI, waist circumference, waist-to-hip ratio, AST, ALT, GGT, HDL, serum glucose, Tot-Chol/HDL, LDL/HDL, TG/HDL, AIP, HOMA, FLI, Kotronen index, VAI, NAFLD liver fat score and LAP, showed a significant improvement(P < 0.01) between baseline and end-treatment.CONCLUSION Outcomes of this study further strengthen the hypothesis that Med Diet and more active lifestyle can be considered a safe therapeutic approach for reducing risk and severity of NAFLD and related disease states. The proposed approach may be proposed as a valid and recommended approach for improving the clinical profile of NAFLD patients. | Chiara Gelli Mirko Tarocchi Ludovico Abenavoli Laura Di Renzo Andrea Galli Antonino De Lorenzo | 2017 | World Journal of Gastroenterology2017，23，17： | 8 |
| 3 | Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3显示文摘Hepatitis C virus(HCV) infection is a common chronic liver disease worldwide.Non-alcoholic fatty liver disease and insulin resistance(IR) are the major determinants of fibrosis progression and response to antiviral therapy.The pathogenetic link between IR and chronic HCV infection is complex,and is associated with HCV genotype.Liver steatosis is the most common in the patients infected with genotype 3 virus,possibly due to direct effects of genotype 3 viral proteins.To the contrary,hepatic steatosis in the patients infected with other genotypes is thought to be mostly due to the changes in host metabolism,involving IR.In HCV genotype 3,liver steatosis correlates with viral load,reverts after reaching the sustained virologic response and reoccurs in the relapsers.A therapeutic strategy to improve IR and liver steatosis and subsequently the response to antiviral treatment in these patients is warranted. | Ludovico Abenavoli Mario Masarone Valentina Peta Natasa Milic Nazarii Kobyliak Samir Rouabhia Marcello Persico | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 4 | Alimentary regimen in non-alcoholic fatty liver disease:Mediterranean diet显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide.The mechanisms of the underlying disease development and progression are awaiting clarification.Insulin resistance and obesity-related inflammation status,among other possible genetic,dietary,and lifestyle factors,are thought to play the key role.There is no consensus concerning the pharmacological treatment.However,the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy.On the basis of its components,the literature reports on the effectiveness of the Mediterranean diet in reducing cardiovascular risk and in preventing major chronic diseases,including obesity and diabetes.New evidence supports the idea that the Mediterranean diet,associated with physical activity and cognitive behaviour therapy,may have an important role in the prevention and the treatment of NAFLD. | Ludovico Abenavoli Natasa Milic Valentina Peta Francesco Alfieri Antonino De Lorenzo Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 5 | Role of endoscopy in management of gastrointestinal complications of portal hypertension显示文摘The management of patients with gastrointestinal complications of portal hypertension is often complex and challenging. The endoscopy plays an important role in the management of these patients. The role of endoscopy is both diagnostic and interventional and in the last years the techniques have undergone a rapid expansion with the advent of different and novel endoscopic modalities, with consequent improvement of investigation and treatment of these patients. The choice of best therapeutic strategy depends on many factors: baseline disease, patient's clinical performance and the timing when it is done if in emergency or a prophylactic approaches. In this review we evaluate the endoscopic management of patients with the gastrointestinal complications of portal hypertension. | Carmelo Luigiano Giuseppe Iabichino Antongiulio Judica Clara Virgilio Valentina Peta Ludovico Abenavoli | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，1： | 5 |
| 6 | Non Alcoholic Fatty Liver: Epidemiology and Natural History显示文摘 | Mario Masarone Alessandro Federico Ludovico Abenavoli Carmela Loguercio Marcello Persico | 2014 | Reviews on Recent Clinical Trials2014，，3： | 4 |
| 7 | Adiponectin serum level in chronic hepatitis C infection and therapeutic profile显示文摘Hepatic steatosis is commonly seen in the patients with chronic hepatitis C virus(HCV) infection. HCV is closely associated with lipid metabolism,and viral steatosis is more common in genotype 3 infection owing to a direct cytopathic effect of HCV core protein. In non-genotype3 infection,hepatic steatosis is considered largely to be the result of the alterations in host metabolism; metabolic steatosis is primarily linked with HCV genotype 1. A d i p o s e t i s s u e s e c r e t e s d i f f e r e n t h o r m o n e s involved in glucose and lipid metabolisms. It has been demonstrated that adipocytokines are involved in the pathogenesis of non-alcoholic fatty liver disease,as the decreased plasma adiponectin levels,a soluble matrix protein expressed by adipoctyes and hepatocyte,are associated with liver steatosis. Various studies have shown that steatosis is strongly correlated negatively with adiponectin in the patients with HCV infection. The role of adiponectin in hepatitis C virus induced steatosis is still not completely understood,but the relationship between adiponectin low levels and liver steatosis is probably due to the ability of adiponectin to protect hepatocytes from triglyceride accumulation by increasing β-oxidation of free fatty acid and thus decreasing de novo free fatty acid production. | Valentina Peta Carlo Torti Natasa Milic Alfredo Foca Ludovico Abenavoli | 2015 | World Journal of Hepatology2015，7，1： | 4 |
| 8 | Silymarin: An option to treat non-alcoholic fatty liver disease显示文摘We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under investigation. Recently, we described the health effects of the Mediterranean diet associated to an antioxidant complex rich in silymarin, to improve in overweight patients anthropometric parameters, glucose and lipid metabolism and intra-hepatic fat accumulation. | Carmela Colica Luigi Boccuto Ludovico Abenavoli | 2017 | World Journal of Gastroenterology2017，23，47： | 2 |
| 9 | Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study显示文摘 | Giovanni Addolorato Lorenzo Leggio Anna Ferrulli Silvia Cardone Luisa Vonghia Antonio Mirijello Ludovico Abenavoli Cristina D’Angelo Fabio Caputo Antonella Zambon Paul S Haber Giovanni Gasbarrini | 2007 | The Lancet2007，，9603： | 1 |
| 10 | Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study显示文摘 | Giovanni Addolorato Lorenzo Leggio Anna Ferrulli Silvia Cardone Luisa Vonghia Antonio Mirijello Ludovico Abenavoli Cristina D’Angelo Fabio Caputo Antonella Zambon Paul S Haber Giovanni Gasbarrini | 2007 | 2007 (9603)2007，，9603： | 1 |
| 11 | A pathogenetic link between non-alcoholic fatty liver disease and celiac disease显示文摘 | Ludovico Abenavoli Natasa Milic Antonino Lorenzo Francesco Luzza | 2013 | Endocrine2013，，1： | 1 |
| 12 | Pharmacotherapy of acute alcoholic hepatitis in clinical practice显示文摘Severe alcoholic hepatitis(AH)is an acute form of alcohol induced liver disease with a poor prognosis that is seen in the patients who consume large quantities of alcohol.The diagnosis of AH is based on the appropriate alcohol intake history and is supported with clinical and histological features,and several scoring systems.Glucocorticoids are the mainstay for treating severe AH with pentoxifylline used as an alternative to steroids in addition to total alcohol abstinence.Liver transplantation is a possible therapeutic option for severe AH.Among the anti-craving medications able to improve abstinence rate,baclofen seems to be effective and safe in the alcoholic patients affected by severe liver damage. | Ludovico Abenavoli Natasa Milic Samir Rouabhia Giovanni Addolorato | 2014 | World Journal of Gastroenterology2014，20，9： | 0 |
| 13 | Hepatitis C virus genotypes in north eastern Algeria: A retrospective study显示文摘AIM: To determine the frequency of various hepatitis C virus (HCV) genotypes present in patients from north eastern Algeria. METHODS: This is a retrospective cross-sectional study of 435 HCV infected patients from northeast Algeria, detected in the Sadelaoud laboratory and diagnosed between January 2010 and December 2012. The patients were diagnosed with HCV infection in their local hospitals and referred to be assessed for HCV genotype before the antiviral treatment. Demographic information (sex, age and address), genotype, subtype and viral load were retrieved from the patient medical records. The serum samples were tested by the type-specific genotyping assay.RESULTS: The majority of the patients (82.5%) were from the central part of the examined region (P = 0.002). The mean age of the patients studied was 53.6 ± 11.5 years. HCV genotype 1 was the most frequent (88.7%), followed by genotypes 2 (8.5%), 4 (1.1%), 3 (0.9%) and 5 (0.2%). Genotype 6 was not detected in these patients. Mixed infection across the HCV subtypes was detected in twenty patients (4.6%). The genotype distribution was related to age and region. Genotype 1 was significantly less frequent in the ≥ 60 age group than in the younger age group (OR = 0.2; 95%CI: 0.1-0.5, P < 0.001). Furthermore, genotype 1 was more frequent in the central part of the examined region than elsewhere (P < 0.01). CONCLUSION: The HCV genotype (type 1b was dominant) distribution in Algeria is different from those in other northern countries of Africa. | Samir Rouabhia Mourad Sadelaoud Karima Chaabna-Mokrane Wided Toumi Ludovico Abenavoli | 2013 | World Journal of Hepatology2013，5，7： | 0 |
| 14 | No evidence of circulating autoantibodies against osteoprotegerin in patients with celiac disease显示文摘AIM:To investigate risk factors for low bone mineral density(BMD) in celiac disease(CD) patients,focusing on circulating autoantibodies against osteoprotegerin(OPG).METHODS:Seventy asymptomatic CD adult patients on gluten-free diet(GFD) and harbouring persistent negative CD-related serology were recruited.Conventional risk factors for osteoporosis(e.g.,age,sex,menopausal status,history of fractures,smoke,and body mass index) were checked and BMD was assessed by dual energy X ray absorptiometry.Serum calcium and parathyroid hormone(PTH) levels were evaluated.Thirty-eight patients underwent repeat duodenal biopsy.Serum samples from a selected sub-group of 30 patients,who were also typed for human leukocyte antigen(HLA) DQ2 and DQ8 haplotype,were incubatedwith homodimeric recombinant human OPG and tested by western blotting with an anti-OPG antibody after immunoprecipitation.RESULTS:Despite persistent negative CD-related serology and strict adherence to GFD,49 out of the 70(74%) patients displayed low BMD.Among these patients,13(24%) showed osteoporosis and 36(76%) osteopenia.With the exception of age,conventional risk factors for osteoporosis did not differ between patients with normal and low BMD.Circulating serum calcium and PTH levels were normal in all patients.Duodenal mucosa healing was found in 31(82%) out of 38 patients who underwent repeat duodenal biopsy with 20(64%) still displaying low BMD.The remaining 7 patients had an incomplete normalization of duodenal mucosa with 6(84%) showing low BMD.No evidence of circulating antibodies against OPG was found in the serum of 30 celiac patients who were tested for,independent of BMD,duodenal histology,and HLA status.CONCLUSION:If any,the role of circulating autoantibodies against OPG in the pathogenesis of bone derangement in patients with CD is not a major one. | Tiziana Larussa Evelina Suraci Immacolata Nazionale Isabella Leone Tiziana Montalcini Ludovico Abenavoli Maria Imeneo Arturo Pujia Francesco Luzza | 2012 | World Journal of Gastroenterology2012，18，14： | 0 |
| 15 | Non-alcoholic fatty liver disease and beneficial effects of dietary supplements显示文摘I read with great interest the review published by Eslamparast et al, on the dietary supplements with hepato-protective properties, and their proposed mechanisms to protect against non-alcoholic fatty liver disease. In this way, recently, our study group reported the efficacy of the Mediterranean diet associated to an antioxidant complex, to improve in overweight patientsnot only anthropometric parameters, but also insulinresistance, lipid serum levels, and intra-hepatic fat accumulation. | Ludovico Abenavoli | 2015 | World Journal of Hepatology2015，7，12： | 0 |
| 16 | Are probiotics effective in reversing non-alcoholic steatohepatitis?显示文摘The gut microbiota(GM)is an integrated ecosystem of tens of trillions of microorganisms,as actinomyces,archaea,protozoa,and last but not least viruses,including one thousand different species of known bacteria with an overall count of more than three million genes,150 times more than the human genome.GM presents immune-modulating,absorptive and metabolic functions(1). | Ludovico Abenavoli Luigi Boccuto Emidio Scarpellini | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 0 |
| 17 | Beneficial effects of coffee in non-alcoholic fatty liver disease:a narrative review显示文摘Non-alcoholic fatty liver disease(NAFLD)is one of the most common liver diseases and is related to unhealthy lifestyle habits,characterized by a diet rich in sugars and fats leading to excessive calorie intake,and lack of exercise.In recent years,there is a growing incidence of this pathology,raising the attention of hepatologists,endocrinologists,diabetologists,and nutritionists.In this context,the alimentary regimen adopted by patients with NAFLD has become an increasingly scrutinised parameter.Diet is now considered a crucial factor in the treatment of NAFLD since it has been observed that some functional foods play a beneficial role.These include coffeewhose health effects have already been amply demonstrated.Here we describe the beneficial effects of coffee consumption reported in the NAFLD literature. | Alessio Calabrò Anna Caterina Procopio Francesco Primerano Tiziana Larussa Francesco Luzza Laura Di Renzo Antonino De Lorenzo Paola Gualtieri Ludovico Abenavoli | 2020 | Hepatoma Research2020，6，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员