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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 3 | Decentralized nonlinear optimal excitation control显示文摘 | Lu Q Sun Y Z Xu Z | 1996 | IEEE Trans on Power System1996，11，4： | 3 |
| 4 | On Marcinkiewicz integral with homogeneous kernels显示文摘 | DING Y LU S Z XUE Q Y | 2000 | J of Mathematical Analysis and Application2000，245，： | 1 |
| 5 | 显示文摘 | Jia W Y Yuan H B Lu L Z | 1998 | Journal of Luminescence1998，7677，： | 1 |
| 6 | Activity of β-C2S under different sintering conditions 显示文摘 | Lu Z Y Tan K F | 1997 | Cement and Concrete Research1997，27，7： | 1 |
| 7 | Complexation of resveratrol with cyclodextrins: solubility and antioxidant activity显示文摘 | Lu Z Cheng B Hu Y L | 2009 | Food Chem2009，113，： | 1 |
| 8 | Synthesis and self-assembly of Au@SiO2 core-shell colloids显示文摘 | Lu Y Yin Y Li Z Y | 2002 | Nano Letters2002，2，7： | 1 |
| 9 | An effective wavelet matrix transform approach for efficient solutions of electromagnetic integral equations显示文摘 | XIANG Z LU Y | 1997 | IEEE Trans AP1997，45，8： | 1 |
| 10 | Pretreatment of Actual High- Strength Phenolic Wastewater by Manganese Oxide Method 显示文摘 | Fan C Z Lu A H Li Y | 2010 | Chemical Engineering Sournal2010，160，1： | 1 |
| 11 | 显示文摘 | Lu J G Ye Z Z Huang J Y | 2002 | Mater Sci SemiconProcess2002，5，： | 1 |
| 12 | Recently Progress in Application of Semipermeable Membrane Devices (SPMDs) in Aquatic Environment 显示文摘 | Lu Y B Wang Z Huckins J | 2002 | Aquatic Toxicology2002，60，12： | 1 |
| 13 | Studies on the reaction methanism of CH4/CO2reforming over Co/γ-Al2O3 catalyst显示文摘 | Lu Y Yu C C Xue J Z | 1997 | Chem Lett1997，，2： | 1 |
| 14 | Behavior of Mg-6Al-xSi alloys during solution heat treatment at 420 ℃显示文摘 | LU Y Z WANG Q D ZENG X Q | 2001 | Materials Science and Engineering2001，301，： | 1 |
| 15 | Regional structure of global warming across China during the twentieth century 显示文摘 | LU A HE Y ZHANG Z | 2004 | Climate Research2004，27，： | 1 |
| 16 | Studies on cutting propagation techniques of Spatholobus suberectus 显示文摘 | HUANG X Y LU H Z PENG Y D | 2010 | Medicinal Plant2010，1，3： | 1 |
| 17 | Analysis of bilinear oscillators under harmonic loading using nonlinear output frequency response functions 显示文摘 | Peng Z K Lang Z Q Billings S A Lu Y | 2007 | International Journal of Mechanical Sciences2007，49，11： | 1 |
| 18 | N20 and NO emissions from co-firing MSW with coals in pilot scale CFBC显示文摘 | Li Z W Lu Q G Na Y J | 2004 | Fuel Processing Technology2004，85，14： | 1 |
| 19 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 20 | DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype显示文摘 | Jiang B Cao Z Lu Y | | 0，，10： | 1 |
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