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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients显示文摘 | Martinez-Llordella M Lozano JJ Puig-Pey I | 2008 | J Clin Invest2008，118，8： | 1 |
| 3 | Evidence for differen- tial localization of annexin VI during mammary secreto- ry differentiation 显示文摘 | Rocha V Lozano JJ Haindl AH | 1990 | Biochem Soc Trans1990，18，6： | 1 |
| 4 | Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis显示文摘 | Balaguer F Link A Lozano JJ | 2010 | Cancer Res2010，70，16： | 1 |
| 5 | Loss of FHIT protein expression is related to high proliferation,low apoptosis and worse prognosis in non-small-cell lung cancer显示文摘 | Toledo G Sola JJ Lozano MD | 2004 | Mud Pathol2004，17，4： | 1 |
| 6 | Loss of FHIT protein expression is related to high proliferation, low apoptosis and Worse Prognosis in non-small-cell lung cancer显示文摘 | Toledo G Sola JJ Lozano MD | 2004 | Mod Pathol2004，17，4： | 1 |
| 7 | Using microRNA profiling in urine samples to develop a non-invasive test for bladder cancer显示文摘 | Mengual L Lozano JJ Ingelmo-Torres M | 2013 | Int J Cancer2013，133，11： | 1 |
| 8 | Correlation between circulating adhesion molecule levels and albuminuria in type-2 diabetic hypertensive patients 显示文摘 | Rubio-Guerra AF Vargas-Robles H Lozano Nuevo JJ | 2009 | Kidney Blood Press Res2009，32，： | 1 |
| 9 | Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients 显示文摘 | Martinez-Llordella M Lozano JJ Puig-Pey I | 2008 | J Clin Invest2008，118，8： | 1 |
| 10 | Correlation between circulating adhesion molecule levels and albuminuria in type -2 diabetic hypertensive patients 显示文摘 | Rubio - Guerra AF Vargas - Robles H Lozano Nuevo JJ | 2009 | Kidney Blood Press Res2009，32，2： | 1 |
| 11 | Dynamic of nasal coloniza-tion by methicillin - resistant Staphylococcus aureus ST398 and ST1after mupirocin treatment in a family in close contact with pigs 显示文摘 | Lozano C Aspiroz C Lasarte JJ | 2011 | Comp Immunol Microbiol Infect Dis2011，34，1： | 1 |
| 12 | Structure-based QSAR study on differential inhibition of human prostaglandin endoperoxide H synthase-2 (COX-2) by nonsteroidal anti-inflammatory drugs显示文摘 | Pouplana R Lozano JJ Perez C | 2002 | J Comput Aided Mol Des2002，16，10： | 1 |
| 13 | Gene expression test for the non-invasive diagnosis of bladder cancer: A prospective, blinded, international and muhicenter validation study 显示文摘 | Ribal M J Mengual L Lozano JJ | 2016 | Eur J Cancer2016，54，13： | 1 |
| 14 | Gene-expression signature of tumor recurrence in patients with stage Ⅱ and Ⅲ colon cancer treated with 5'fluoruracilbased adjuvant chemotherapy显示文摘 | Girdldez MD Lozano JJ Cuatrecasas M | 2013 | Int J Cancer2013，132，5： | 1 |
| 15 | Loss of FHIT protein expression is related to high proliferation,low apoptosis and Worse Prognosis in non-small-cell lung cancer显示文摘 | Toledo G Sola JJ Lozano MD | 2004 | Mod Pathol2004，17，4： | 1 |
| 16 | Loss of FHIT protein expression is related to high proliferation,low apoptosis and worse prognosis in non-small-cell lung cancer显示文摘 | Toledo G Sola JJ Lozano MD | 2004 | Mod Pathol2004，17，： | 1 |
| 17 | Searehing for the achilles heel of FOXP3 显示文摘 | Lozano T Casares N Lasarte JJ | 2013 | Front Oneol2013，3294，： | 1 |
| 18 | Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients:correlation with clinical outcomes显示文摘 | Lozano MD Zulueta JJ Echeveste JI | 2011 | Oncologist2011，16，6： | 1 |
| 19 | Predictive value of MieroRNAs in the progression of barrett esophagus to adenocarci- noma in a long-term follow-up study 显示文摘 | Revilla-Nuin B ParHlla P Lozano JJ | 2013 | Ann Surg2013，257，5： | 1 |
| 20 | Gene dis- covery in bladder progression using cDNA microarrays显示文摘 | Sanchez-Carbayo M Socci ND Lozano JJ | 2003 | Am J Pathol2003，163，2： | 1 |
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