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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Molecular cloning of the cDNA encoding laccase from Pycnoporus cinnabarinus I 937 and expression in Pichia pastoris 显示文摘 | Otterbeinl L Recordl E Longhi S | 2000 | Eur J Biochem2000，267，： | 2 |
| 3 | Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury显示文摘 | WATSON D J LONGHI L LEE E B | 2003 | J Neuropathol Exp Neurol2003，62，4： | 1 |
| 4 | Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice显示文摘 | LONGHI L WATSON D J SAATMAN K E | 2004 | J Neurotrauma2004，21，12： | 1 |
| 5 | uCyt+ test:altemative to cystoscopy for less-invasive follow-up of patients with low risk of urothelial carcinoma显示文摘 | Lodde M Mian C Comploj E Palermo S Longhi E Marberger M | | 0，，： | 1 |
| 6 | Memory in Two-dimensional Heap Experiments 显示文摘 | GENG Jun-fei LONGHI E BEHRINGER R P | 2001 | Physical Review E2001，64，6： | 1 |
| 7 | Second malignancy in 597 patients with Ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999 显示文摘 | Bacci G Longhi A Barbieri E | 2005 | J Pediatr Hematol Oncol2005，27，10： | 1 |
| 8 | Intracranial pressure monitoring for traumatic brain injury: available evidence and clinical implications 显示文摘 | Stocchetti N Longhi L Zanier E R | 2008 | Minerva Anestesiol2008，74，5： | 1 |
| 9 | Non-redundant role for IL-12 and IL-27 in modulating Th2 polarization of eareinoembryonieantigen specific CD4 T cells from pancreatic cancer patients 显示文摘 | Tassi E BragaM Longhi R | 2009 | PLoS One2009，4，10： | 1 |
| 10 | Non-redundant role for IL-12and IL-27 in modulating Th2 polarization of carcincembryonic antigen specific CD4 T cells from pancreatic cancer patients显示文摘 | Tassi E Braga M Longhi R | 2009 | PLoS One2009，4，10： | 1 |
| 11 | Motor and cognitive function evaluation following experimental traumatic brain injury 显示文摘 | Fujimoto S T Longhi L Saatman K E | 2004 | Neurosci Biobehav Rev2004，28，4： | 1 |
| 12 | Mechanism of residence of cytochrome b(5), a tail-anchored protein, in the endoplasmic reticulum显示文摘 | Pedrazzini E Villa A Longhi R | 2000 | J Cell Biol2000，148，5： | 1 |
| 13 | Molecular cloning of the cDNA encoding laccase from Pycnoporus cinnabarinus 1-937 and expression in Pichia pastoris显示文摘 | Otterbein L Record E Longhi S | 2000 | Eur J Biochem2000，267，6： | 1 |
| 14 | MMIC LNAs for Radioastronomy Applications Using Advanced Industrial 70 nm Metamorphic Technology显示文摘 | Ciccognani W Limiti E Longhi P E | | 0，，10： | 1 |
| 15 | Non- redundant role for IL-12 and IL-27 in modulating Th2 polarization of carcinoembryonic antigen specific CD4 T cells from pancreatic cancer patients 显示文摘 | TASSI E BRAGA M LONGHI R | 2009 | PLoS One2009，4，10： | 1 |
| 16 | Identification of HLA-B*4905 in a Caucasian family显示文摘 | Andreni E Longhi E Frison S | 1999 | Tissue Antigens1999，53，3： | 1 |
| 17 | Minimization of volatile nitrogen oxides interference in the determination of arsenic by hydride generation atomic ab-sorption spectrometry显示文摘 | E′rico Marlon de Moraes Flores Let′lcia Longhi Cirne da Sil-va | 2001 | Spectrochimica Acta Part B2001，56，： | 1 |
| 18 | Cerebral oxygen consumption and ischemia in traumatic brain injury显示文摘 | Stocchetti N Roncati Zanier E Canavesi K Magnoni S Protti A Longhi L | 2004 | Minerva Anest- esiol2004，70，： | 1 |
| 19 | Patterns in taxonomic and functional diversity of lake phytoplankton 显示文摘 | Longhi M L Beisner B E | 2010 | Freshwater Biology2010，55，6： | 1 |
| 20 | Stem cell transplantation as a therapeutic strategy for traumatic brain injury 显示文摘 | Longhi L Zanier E Royo N | 2005 | Transpt Immunol2005，15，2： | 1 |
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