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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 3 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 4 | HSV -1 thymidine kinase gene therapy for colorectal adenocarcinoma - derived peritoneal carcinomatosis 显示文摘 | Lechanteur C Princen F Lo Bue S | 1997 | Gene Ther1997，4，11： | 1 |
| 5 | Kinetics g plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma 显示文摘 | Lo Y M Leung S F Chart L Y | 2000 | Cancer Res2000，60，： | 1 |
| 6 | Expression of frizzledrelated protein and Wnt-signalling molecules in invasive human breast tumours显示文摘 | Wong S C Lo S F Lee K C | 2002 | J Pathol2002，196，2： | 1 |
| 7 | Cloning and characterizationof Arabidopsis thaliana pyridoxal kinase 显示文摘 | Lum H K Kwok F Lo S C | 2002 | Planta2002，215，： | 1 |
| 8 | Molecular prognostication of nasopharygeal carcinoma by quantitative analysis Of circulating Epstein-Barr virus DNA 显示文摘 | LO Y M LEUNG S F CHAN L Y | 2000 | CancerRes2000，60，： | 1 |
| 9 | Interventional treatment of sialoliths in main salivary glands 显示文摘 | Cannizzaro F Lo Casto A | 2002 | Radiol Med(Torino)2002，103，4： | 1 |
| 10 | The investigation of electrochemical properties and ionic motion of functionalized copolymer electrolytes based on polysiloxane 显示文摘 | WANG F M HU C C LO S C | 2009 | Solid State Ionics2009，180，45： | 1 |
| 11 | Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma显示文摘 | Cooper K Herrington C S Lo E F | 1992 | J Clin Pathol1992，45，： | 1 |
| 12 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 13 | The novel organization andcomplete sequence of the ribosomal RNA gene of Nosema bombycis显示文摘 | Huang W F Tsai S J Lo C F Y | 2004 | Fungal Genet Biol2004，41，5： | 1 |
| 14 | Identification of two plastid proteins in the dinoflagellate Alexandrium affine that are substantially down-regulated by nitrogen-depletion 显示文摘 | LEE F W-F MORSE D LO S C-L | 2009 | Journal of Proteome Research2009，8，11： | 1 |
| 15 | ATRA and arsenic trioxide (ATO) versus ATRA and idarubicin (AI- DA) for newly diagnosed, non high-risk acute promyelo- cytie leukemia (APL) : results of the phase III, prospec- tive, randomized, intergroup APL0406 study by the Ital- ian-German cooperative groups GIMEMA-SAL-AMLSG 显示文摘 | Lo Coco F Avvisati G Orlando S M | 2012 | Blood2012，120，1： | 1 |
| 16 | The flow patterns and stresses on the wall in a symmetric louvered-wall moving granular filter bed显示文摘 | Chou C S Lo W F Smid J | 2003 | Powder Technology2003，131，23： | 1 |
| 17 | The Synthesis and Characterization of Phosphorus-doped Diamond Films Using Trimethyl-phosphite as a Dopping Source 显示文摘 | Chen C F Lo S F Chen S H | 1996 | Diam Relat Mater1996，5，68： | 1 |
| 18 | Prevalence, severity, and risk variables associated with gingival overgrowth in renal transplant subjects treated under tacrolimus or cyclosporin regimens 显示文摘 | de Oliveira Costa F Diniz Ferreira S de Miranda Cota LO | 2006 | J Periodontol2006，77，6： | 1 |
| 19 | Sonographic features of phyllodes tumors of the breast显示文摘 | Chao T C Lo Y F Chen S C | 2002 | Ultrasound Obster Gynecol2002，20，1： | 1 |
| 20 | A molecular isotopic study of ^13 C-enriched organic matter in evaporitic deposits: recognition of CO2 limited ecosystems 显示文摘 | SCHOUTEN S HARTGERS W A LO PEZ J F | 2001 | Organic Geochemistry2001，32，： | 1 |
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