|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 2 | Paleoclimate Modeling in China: A Review显示文摘This paper provides a review of paleoclimate modeling activities in China. Rather than attempt to cover all topics, we have chosen a few climatic intervals and events judged to be particularly informative to the international community. In historical climate simulations, changes in solar radiation and volcanic activity explain most parts of reconstructions over the last millennium prior to the industrial era, while atmospheric greenhouse gas concentrations play the most important role in the20 th century warming over China. There is a considerable model–data mismatch in the annual and boreal winter temperature change over China during the mid-Holocene [6000 years before present(ka BP)], while coupled models with an interactive ocean generally perform better than atmospheric models. For the Last Glacial Maximum(21 ka BP), climate models successfully reproduce the surface cooling trend over China but fail to reproduce its magnitude, with a better performance for coupled models. At that time, reconstructed vegetation and western Pacific sea surface temperatures could have significantly affected the East Asian climate, and environmental conditions on the Qinghai–Tibetan Plateau were most likely very different to the present day. During the late Marine Isotope Stage 3(30–40 ka BP), orbital forcing and Northern Hemisphere glaciation, as well as vegetation change in China, were likely responsible for East Asian climate change. On the tectonic scale,the Qinghai–Tibetan Plateau uplift, the Tethys Sea retreat, and the South China Sea expansion played important roles in the formation of the East Asian monsoon-dominant environment pattern during the late Cenozoic. | JIANG Dabang YU Ge ZHAO Ping CHEN Xing LIU Jian LIU Xiaodong WANG Shaowu ZHANG Zhongshi YU Yongqiang LI Yuefeng JIN Liya XU Ying JU Lixia ZHOU Tianjun YAN Xiaodong | 2015 | Advances in Atmospheric Sciences2015，32，2： | 12 |
| 3 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 4 | Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances显示文摘Lactic acid bacteria(LAB)are a representative probiotic.As the dominant flora in the human intestinal tract,LAB can regulate the balance of human intestinal flora and improve host health.The purpose of this study was to isolate and screen LAB that are well suited to the intestinal characteristics of the Chinese population,with excellent probiotics and high antibacterial activity.After 16S ribosomal RNA(rRNA)homology and phylogenetic tree analysis,potential probiotics were tested for their antibacterial activity,resistance to artificial gastrointestinal fluid and drugs,surface hydrophobicity,and safety.Three strains of LAB with acid resistance,bile salt resistance,epithelial cell adhesion,and no multidrug resistance were selected:Lactobacillus salivarius,Leuconostoc lactis,and Lactobacillus paracasei.Analysis of the antibacterial active substances in the three strains and their fermentation broths revealed that the main antibacterial substances of L.lactis were organic acids,whereas those of L.salivarius and L.paracasei were organic acids and bacteriocins with broad-spectrum antibacterial activity.These three strains of probiotic LAB with high antibacterial activity were identified as bacterial resources that could potentially be used to develop probiotic preparations for the prevention and treatment of intestinal diseases caused by intestinal pathogens. | Zhijing LIU Cong XU Ran TIAN Wan WANG Jiage MA Liya GU Fei LIU Zhanmei JIANG Juncai HOU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，7： | 10 |
| 5 | Autologous hematopoietic stem cell transplantation in chemotherapy-sensitive lymphoblastic lymphoma: treatment outcome and prognostic factor analysis显示文摘Objective: The study evaluated the effectiveness of autologous hematopoietic stem cell transplantation(AHSCT) in the treatment of lymphoblastic lymphoma(LL).Methods: We retrospectively analyzed the data from 41 patients with chemotherapy-sensitive LL who underwent hematopoietic stem cell transplantation(HSCT) from December 1989 to December 2009 in a single institution.Results: HSCT was conducted as first-line consolidation therapy and salvage therapy in 36 and 5 patients, respectively. The median follow-up was 97.1 months(range, 24.6-173.1 months). The 5-year overall survival(OS) and event-free survival(EFS) rate were 64% and 47% for the initially treated patients, respectively, and were both 20% for the relapsed ones. Bone marrow(BM) involvement and chemotherapy cycles prior to transplantation were identified as significant prognostic factors for EFS in multivariate analysis.Conclusions: These results confirm that AHSCT is a reasonable option for chemotherapy-sensitive LL patients in first complete remission(CR1). | Youwu Shi Shengyu Zhou Xiaohui He Xiaohong Han Shikai Wu Feng Pan Peng Liu Yinyu Liu Yingheng Lei Hongzhi Zhang Jianliang Yang Yan Qin Changgong Zhang Sheng Yang Liya Zhao Kehuan Luo Guanqing Wu Yan Sun Yuankai Shi | 2015 | Chinese Journal of Cancer Research2015，27，1： | 9 |
| 6 | Epigenetic regulation and epigenomic landscape in rice显示文摘Epigenetic regulation has been implicated in the control of complex agronomic traits in rice(Oryza sativa),a staple food crop and model monocot plant. Recent advances in high-throughput sequencing and the moderately complex genome of rice have made it possible to study epigenetic regulation in rice on a genome-wide scale. This review discusses recent advances in our understanding of epigenetic regulation in rice, with an emphasis on the roles of key epigenetic regulators, the epigenomic landscape, epigenetic variation, transposon repression, and plant development. | Xian Deng Xianwei Song Liya Wei Chunyan Liu Xiaofeng Cao | 2016 | National Science Review2016，3，3： | 8 |
| 7 | Enzyme@silica nanoflower@metal-organic framework hybrids: A novel type of integrated nanobiocatalysts with improved stability显示文摘一个新奇综合 nanobiocatalyst 系统基于 enzyme@silica,有改进稳定性的 nanoflower@metal 器官的框架(enzyme@SNF@ZIF-8 ) 结构第一次被制作。这个系统的通用性作为模型酶用青霉素 G acylase (针网阵列) 和过氧化氢酶(猫) 被验证。多微孔的 ZIF-8 层能被改变 ZIF-8 涂层周期的数字控制,它与不同 ZIF-8 层厚度生产 PGA@SNF@ZIF-8 nanobiocatalysts。在第二个 ZIF-8 涂层周期以后, PGA@SNF@ZIF-8 (2 ) 结构与一同类并且 well-intergrown ZIF-8 层被形成,它拥有优秀机械、化学的稳定性。而且, PGA@SNF@ZIF-8 (2 ) 表演与在硅石 nanoflowers (PGA@SNF ) 上使不能调动的免费针网阵列和针网阵列相比改进了 thermal/storage 稳定性和可重用性。获得的基于猫的 nanobiocatalysts (CAT@SNF@ZIF-8 (2 )) 也显示出优秀催化性能。 | Yingjie Du Jing Gao Huajiao Liu Liya Zhou Ying He Zhihong Huang Yanjun Jiang | 2018 | Nano Research2018，11，8： | 5 |
| 8 | Formal Reasoning About Finite-State Discrete-Time Markov Chains in HOL显示文摘Markov chains are extensively used in modeling different aspects of engineering and scientific systems, such as performance of algorithms and reliability of systems. Different techniques have been developed for analyzing Markovian models, for example, Markov Chain Monte Carlo based simulation, Markov Analyzer, and more recently probabilistic model-checking. However, these techniques either do not guarantee accurate analysis or are not scalable. Higher-order-logic theorem proving is a formal method that has the ability to overcome the above mentioned limitations. However, it is not mature enough to handle all sorts of Markovian models. In this paper, we propose a formalization of Discrete-Time Markov Chain (DTMC) that facilitates formal reasoning about time-homogeneous finite-state discrete-time Markov chain. In particular, we provide a formal verification on some of its important properties, such as joint probabilities, Chapman-Kolmogorov equation, reversibility property, using higher-order logic. To demonstrate the usefulness of our work, we analyze two applications: a simplified binary communication channel and the Automatic Mail Quality Measurement protocol. | Liya Liu Osman Hasan Sofiène Tahar | 2013 | Journal of Computer Science & Technology2013，28，2： | 4 |
| 9 | Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma显示文摘Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP) is an eicient treatment of non-Hodgkin's lymphoma(NHL). This study aimed to assess the eicacy and toxicity of dose-adjusted CHOP alone or in combination with rituximab(R-CHOP) by examining the stem cell mobilization in NHL patients. Factors afecting the collection of CD34+ cells were also explored.Methods: Our retrospective study included 39 patients eligible for autologous stem cell transplantation: 14 patients who expressed CD20 and were inancially eligible received R-CHOP for autologous peripheral blood stem cell(APBSC) mobilization; the remaining 25 patients received CHOP.Results: The median CD34+ cell yield was 7.01 × 106 cells/kg body weight(range 1.49–28.39 × 106 cells/kg body weight), with only two patients failing to meet the target CD34+ cell harvest of ber of apheresis procedures per patient was 1(range 1–3). The≥2.0 APBS× 106 cells/kg body weight. The median numC mobilization yield of the CHOP group appeared to be higher than that of the R-CHOP group(P response(CR) rate in = 0.005), whereas the success rate was similar between groups. R-CHOP elevated the completeB cell lymphoma patients as compared with CHOP(P = 0.01). No signiicant diferences in toxicity or engraftment were observed between the two groups.Conclusion: The present study demonstrated that dose-adjusted CHOP chemotherapy efectively mobilized APBSCs in NHL patients and that the addition of rituximab to dose-adjusted CHOP chemotherapy elevated the CR rate for patients with B-cell lymphoma. | Yuankai Shi Ping Zhou Xiaohong Han Xiaohui He Shengyu Zhou Peng Liu Jianliang Yang Changgong Zhang Lin Gui Yan Qin Sheng Yang Liya Zhao Jiarui Yao Shuxiang Zhang | 2015 | Chinese Journal of Cancer2015，34，11： | 4 |
| 10 | Oxidation behavior of Hf-modified platinum aluminide coatings during thermal cycling显示文摘Platinum aluminide coatings with different Hf contents were fabricated by using HfCl_4. The oxidation kinetics and the rumpling behavior of oxide scale were investigated. After thermal cycling, the coating with 0.46 wt% Hf showed least weight gain. With the increase of Hf content, rumpling extent of the scale decreased. Meanwhile, HfO_2 preferentially formed in the scale resulting in the increase of scale thickness. The oxidation of excessive Hf even caused the spallation of the scale. The results in the present study indicate that although Hf plays an important role in decreasing rumpling extent of TGO, the oxidation of Hf decreases the adhesion of the scale. | Liya Ye Hongfei Chen Guang Yang Bin Liu Yanfeng Gao | 2018 | Progress in Natural Science:Materials International2018，28，1： | 3 |
| 11 | Energy Conversion Efficiency of Rainbow Shape Piezoelectric Transducer显示文摘With the aim to enhance the energy conversion efficiency of the rainbow shape piezoelectric transducer, an analysis model of energy conversion efficiency is established based on the elastic mechanics theory and piezoelectricity theory. It can be found that the energy conversion efficiency of the rainbow shape piezoelectric transducer mainly depends on its shape parameters and material properties from the analysis model. Simulation results show that there is an optimal length ratio to generate maximum energy conversion efficiency and the optimal length ratios and energy conversion efficiencies of beryllium bronze substrate transducer and steel substrate transducer are (0.65, 2.21%) and (0.65, 1.64%) respectively. The optimal thickness ratios and energy conversion efficiencies of beryllium bronze substrate transducer and steel substrate transducer are (1.16, 2.56%) and (1.49, 1.57%) respectively. With the increase of width ratio and initial curvature radius, both the energy conversion efficiencies decrease. Moreover, beryllium bronze flexible substrate transducer is superior to the steel flexible substrate transducer. | LIU Xiangjian CHEN Renwen ZHU Liya | 2012 | Chinese Journal of Aeronautics2012，25，5： | 3 |
| 12 | Neurobiological disruptions induced in brains of the rats fed with mercury contami- nated rice collected from experimental fields in Guizhou Province, China显示文摘Guizhou Province, located in the southwestern China, is an important mercury (Hg) production center. High levels of Hg were found in local environmental and biomass samples. The neurobiological disruptions induced in brains of rats fed with Hg polluted rice collected from two experimental plots in Guizhou Province were studied. The plots are close to the Hg mine of Wanshang area and a chemical plant (where Hg is used as a catalyst for the pro-duction of acetaldehyde) of Qingzhen area. Rats were fed for 30 d before toxicological end points were tested. The results showed that the accumulations of Hg in rat’s brain of Qingzhen chemical plant group and Wanshang mine group were significantly higher than those of Shanghai group (con-trol group) (P<0.01). The neural transmitters, including ace-tylcholine (Ach), acetylcholine enzyme (AchE), nitric oxide and nitricoxide synthase (NOS), in rat’s brain were signifi-cantly affected. Oxidative stress was observed in the expo-sure groups. The expression levels of the immediately early gene (IEG), c-fos and c-FOS proteins were induced by the Hg polluted rice. It was noted that the IEG (c-fos) participated in the neurotoxic process induced by the Hg polluted rice. IEG response to Hg might be dependent on interactions between neural transmitter and oxidative damage. c-fos could be used as an effective index of detecting and assessing the neurotox-icity of Hg. The results suggested that it should be alert to mental health problem in human beings eating Hg-polluted food. More efforts are necessary to protect the local ecosys-tem and human health in the Hg polluted areas such as Wangshan and Qingzhen in Guizhou Province of China. | CHENG Jinping YUAN Tao YANG Liu HU Weixuan ZHENG Min WANG Wenhua LIU Xiaojie QU Liya | 2005 | Chinese Science Bulletin2005，50，21： | 3 |
| 13 | Efficacy of Carbamazepine Combined with Botulinum Toxin A in the Treatment of Blepharospasm and Hemifacial Spasm显示文摘Purpose:To observe the efficacy of the combined treatment of carbamazepine and botulinum toxin A for blepharospasm and hemifacial spasm. Methods:Fifty-eight patients with either blepharospasm or hemifacial spasm were randomly divided into treatment and control groups. In the treatment group, 30 patients were administered with local intramuscular injections of botulinum toxin A and oral carbamazepine 100 mg/time,3 times/day for 60 days. Twenty-eight subjects in the control group under-went local intramuscular injections of botulinum toxin A only. Results:After combined treatment, the complete remission rate was 90%, which was significantly higher than that of the of the control group (67.9% , P<0.05,χ2 =4.733). However, no statistical significance was noted regarding the duration of therapeutic effects between the treatment group (range 14~40 weeks; 19.2 weeks on average) and control group (range 12~36 weeks; 18 weeks on average). Conclusion:The combined therapy of carbamazepine and topical injections of botulinum toxin A had increased efficacy in the treatment of blepharospasm or hemifacial spasm, but had no significant effect in terms of the duration of the therapeutic effect. | Xianhua Li Shaochun Lin Yanfei Hu Liya Liu Jubo Liu Yichun Hong | 2012 | Eye Science2012，27，4： | 2 |
| 14 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 15 | Functional markers developed from TaGS3, a negative regulator of grain weight and size, for marker-assisted selection in wheat显示文摘The TaGS3 homoeologous genes(homoeologs)located on chromosomes 7 A,4 A,and7 D in hexaploid wheat were cloned.Relative expression analysis of the three Ta GS3 homoeologs revealed that the expression levels of TaGS3-4 A and TaGS3-7 D in developing grains were higher than that of TaGS3-7 A.Genetic evidence showed that Ta GS3 was a negative regulator of grain weight and grain size.Fifteen polymorphic sites and five haplotypes were detected in TaGS3-4 A.Two molecular markers were developed to distinguish the five haplotypes.Association analysis using 260 accessions from Chinese wheat mini-core collection(MCC)indicated that TaGS3-4 A affected thousand grain weight(TGW)and grain length(GL).HAP-4 A-1 and HAP-4 A-2 were favorable haplotypes that increased TGW and GL and had undergone strong selection during domestication of wheat.In addition,interaction of the TaGS3-4 A and TaGS3-7 D homoeologs had significant additive effects on the grain traits.Hap-4 A-1/Hap-7 D-2 was the best haplotype combination in increasing TGW and GL.The frequencies and geographic distributions of favorable TaGS3 haplotypes among 1388 wheat accessions from worldwide sources provided clues for selection of yield-related traits.Our findings demonstrated that TaGS3-4 A had significant effects on TGW and GL.Marker-assisted selection of HAP-4 A-1/2 combined with HAP-7 D-2 has potential to increase wheat yields. | Wei Zhang Huifang Li Liya Zhi Qiannan Su Jiajia Liu Xiaoli Ren Deyuan Meng Na Zhang Jun Ji Xueyong Zhang Junming Li | 2020 | The Crop Journal2020，8，6： | 2 |
| 16 | Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles显示文摘Ubiquitination,an essential post-transcriptional modification(PTM),plays a vital role in nearly every biological process,including development and growth.Despite its functions in plant reproductive development,its targets in rice panicles remain unclear.In this study,we used proteome-wide profiling of lysine ubiquitination in rice(O.sativa ssp.indica)young panicles.We created the largest ubiquitinome dataset in rice to date,identifying 1638 lysine ubiquitination sites on916 unique proteins.We detected three conserved ubiquitination motifs,noting that acidic glutamic acid(E)and aspartic acid(D)were most frequently present around ubiquitinated lysine.Enrichment analysis of Gene Ontology(GO)annotations and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways of these ubiquitinated proteins revealed that ubiquitination plays an important role in fundamental cellular processes in rice young panicles.Interestingly,enrichment analysis of protein domains indicated that ubiquitination was enriched on a variety of receptorlike kinases and cytoplasmic tyrosine and serine-threonine kinases.Furthermore,we analyzed the crosstalk between ubiquitination,acetylation,and succinylation,and constructed a potential protein interaction network within our rice ubiquitinome.Moreover,we identified ubiquitinated proteins related to pollen and grain development,indicating that ubiquitination may play a critical role in the physiological functions in young panicles.Taken together,we reported the most comprehensive lysine ubiquitinome in rice so far,and used it to reveal the functional role of lysine ubiquitination in rice young panicles. | Liya Zhu Han Cheng Guoqing Peng Shuansuo Wang Zhiguo Zhang Erdong Ni Xiangdong Fu Chuxiong Zhuang Zexian Liu Hai Zhou | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 2 |
| 17 | An international multicentric phaseⅢrandomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer:a study protocol显示文摘OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and depression.METHODS:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data entry.Patients with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant chemotherapy.Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation.In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this study.RESULTS:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment.Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly.Unfortunately,we do not have effective pharmacological interventions yet.And clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been reported.CONCLUSION:The findings of the trial will allow us to determine the effects of acupuncture treatment approach.We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments. | Saghachian Mahasti Barry Caroline Asselain Bernard LI Yunfen NIE Jianyun LIU Dequan CHEN Dedian CHEN Chunxin Laura Estevez LI Wenhui Jean-Pierre Armand ZHU Miansheng JU Liya | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 2 |
| 18 | Volatile organic compounds concentration profiles and control strategy in container manufacturing industry:Case studies in China显示文摘Volatile organic compounds(VOCs),important precursors of ozone(O_(3))and fine particulate matter(PM_(2.5)),are the key to curb the momentum of O_(3)growth and further reducing PM_(2.5)in China.Container manufacturing industry is one of the major VOC emitters,and more than 96%containers of the world are produced in China,with the annual usage of coatings of over 200,000 tons in recent years.This is the first research on the emission characteristics of VOCs in Chinese container manufacturing industry,including concentration and ozone formation potential(OFP)of each species.The result shows that the largest amounts of VOCs are emitted during the pretreatment process,followed by the paint mixing process and primer painting process,and finally other sprays process.The average VOC concentrations in the workshops,the exhausts before treatment and the exhausts after treatment are ranging from 82.67–797.46,170–1,812.65,66.20–349.63 mg/m^(3),respectively.Benzenes,alcohols and ethers are main species,which contribute more than 90%OFP together.Based on the emission characteristics of VOCs and the technical feasibility,it is recommended to set the emission limit in standard of benzene to 1.0 mg/m^(3),toluene to 10 mg/m^(3),xylene to 20 mg/m^(3),benzenes to 40 mg/m^(3),alcohols and ethers to 50 mg/m^(3),and VOCs to 100 mg/m^(3).The study reports the industry emission characteristics and discusses the standard limits,which is a powerful support to promote VOCs emission reduction,and to promote the coordinated control of PM_(2.5)and O_(3)pollution. | Yunting Ke Ruiyuan Liu Xiaofang Chen Yang Feng Ping Gao Haomin Huang Liya Fan Daiqi Ye | 2021 | Journal of Environmental Sciences2021，33，6： | 2 |
| 19 | Strengthened Indian summer monsoon brought more rainfall to the western Tibetan Plateau during the early Holocene显示文摘The Tibetan Plateau(TP)is considered to be the‘‘Third Pole”of the earth because of its huge area(5 million km2),its high elevation(>4000 m average altitude),and the presence of more than 100,000 km2 of glaciers in this northern mid-latitude region.As a result of these factors,the TP influences both short-term regional and large-scale atmospheric circulation and long-term climate change[1].More than ten large rivers originate from the TP and constitute an essential water supply for nearly one sixth of the global population.Hence the TP is often referred to as‘‘the water tower of Asia”[1,2].Variations of summer rainfall over the TP greatly impact inland closed lakes,river discharge,glaciers,plant phenology,and natural hazards[2]. | Xiangjun Liu Xiaojian Zhang Yanluan Lin Liya Jin Fahu Chen | 2019 | Science Bulletin2019，64，20： | 1 |
| 20 | Grey-ey-RBF Neural Network Prediction Model for City Electricity Demand Forecasting显示文摘 | Liu Hongyan Cai Liya Wu Xiaojuan | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员