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| 1 | Olmutinib(HM61713) reversed multidrug resistance by inhibiting the activity of ATPbinding cassette subfamily G member 2 in vitro and in vivo显示文摘Overexpressing of ATP-binding cassette(ABC) transporters is the essential cause of multidrug resistance(MDR), which is a significant hurdle to the success of chemotherapy in many cancers.Therefore, inhibiting the activity of ABC transporters may be a logical approach to circumvent MDR.Olmutinib is an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI), which has been approved in South Korea for advanced EGFR T790 M-positive non-small cell lung cancer(NSCLC). Here,we found that olmutinib significantly increased the sensitivity of chemotherapy drug in ABCG2-overexpressing cells. Furthermore, olmutinib could also increase the retention of doxorubicin(DOX) and rhodamine 123(Rho 123) in ABC transporter subfamily G member 2(ABCG2)-overexpressing cells. In addition, olmutinib was found to stimulate ATPase activity and inhibit photolabeling of ABCG2 with [^(125) I]-iodoarylazidoprazosin(IAAP). However, olmutinib neither altered ABCG2 expression at protein and m RNA levels nor blocked EGFR, Her-2 downstream signaling of AKT and ERK. Importantly,olmutinib enhanced the efficacy of topotecan on the inhibition of S1-MI-80 cell xenograft growth. All the results suggest that olmutinib reverses ABCG2-mediated MDR by binding to ATP bind site of ABCG2 and increasing intracellular chemotherapeutic drug accumulation. Our findings encouraged to further clinical investigation on combination therapy of olmutinib with conventional chemotherapeutic drugs in ABCG2-overexpressing cancer patients. | Zhiqiang Zhang Xiaoran Guo Kenneth K.W.To Zhen Chen Xiaona Fang Min Luo Chunling Ma Jianhua Xu Shirong Yan Liwu Fu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 9 |
| 2 | Genetic diversity and DNA fingerprinting in jute(Corchorus spp.) based on SSR markers显示文摘Genetic diversity analysis and DNA finger printing are very useful in breeding programs,seed conservation and management. Jute(Corchorus spp.) is the second most important natural fiber crop after cotton. DNA fingerprinting studies in jute using SSR markers are limited. In this study, 58 jute accessions, including two control varieties(Huangma 179 and Kuanyechangguo) from the official variety registry in China were evaluated with 28 pairs of SSR primers. A total of 184 polymorphic loci were identified. Each primer detected 3 to 15 polymorphic loci, with an average of 6.6. The 58 jute accessions were DNA-fingerprinted with 67 SSR markers from the 28 primer pairs. These markers differentiated the 58 jute accessions from one another, with Co SSR305-120 and Co SSR174-195 differentiating Huangma 179 and Kuanyechangguo, respectively. NTSYS-pc2.10 software was used to analyze the genetic diversity in the 58 jute accessions. Their genetic similarity coefficients ranged from 0.520 to 0.910 with an average of 0.749, indicating relatively great genetic diversity among them. The 58 jute accessions were divided into four groups with the coefficient 0.710 used as a value for classification, consistent with their species and pedigrees. All these results may be useful both for protection of intellectual property rights of jute accessions and for jute improvement. | Liwu Zhang Rongrong Cai Minhang Yuan Aifen Tao Jiantang Xu Lihui Lin Pingping Fang Jianmin Qi | 2015 | The Crop Journal2015，3，5： | 8 |
| 3 | Secalonic acid D induces cell apoptosis in both sensitive and ABCG2-overexpressing multidrug resistant cancer cells through upregulating c-Jun expression显示文摘Secalonic acid D(SAD) could inhibit cell growth in not only sensitive cells but also multidrug resistant(MDR) cells. However, the molecular mechanisms need to be elucidated. Here, we identified that SAD possessed potent cytotoxicity in 3 pairs of MDR and their parental sensitive cells including S1-MI-80 and S1,H460/MX20 and H460, MCF-7/ADR and MCF-7 cells. Furthermore, SAD induced cell G2/M phase arrest via the downregulation of cyclin B1 and the increase of CDC2 phosphorylation. Importantly, JNK pathway upregulated the expression of c-Jun in protein level and increased c-Jun phosphorylation induced by SAD, which was linked to cell apoptosis via c-Jun/Src/STAT3 pathway. To investigate the mechanisms of upregulation of c-Jun protein by SAD, the mR NA expression level and degradation of c-Jun were examined. We found that SAD did not alter the mR NA level of c-Jun but inhibited its proteasome-dependent degradation. Taken together, these results implicate that SAD induces cancer cell death through c-Jun/Src/STAT3 signaling axis by inhibiting the proteasome-dependent degradation of c-Jun in both sensitive cells and ATP-binding cassette transporter sub-family G member 2(ABCG2)-mediated MDR cells. | Hong Zhang Liyan Huang Liyang Tao Jianye Zhang Fang Wang Xu Zhang Liwu Fu | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 5 |
| 4 | In Situ Regeneration of Mo/MCM-22 with 1%O_2 at Reaction Temperature显示文摘 | BAI Jie, XIE Sujuan, LIU Shenglin, XU Longya, LIN Liwu (State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning, China) | 2003 | 催化学报2003，24，11： | 4 |
| 5 | Enhanced Moth-flame Optimization Based on Cultural Learning and Gaussian Mutation显示文摘 | Liwu Xu Yuanzheng Li Kaicheng Li Gooi Hoay Beng Zhiqiang Jiang Chao Wang Nian Liu | 2018 | Journal of Bionic Engineering2018，15，4： | 4 |
| 6 | Fast formation of NaA zeolite membrane in the microwave field显示文摘NaA zeolite membrane was successfully synthesized on the porous α-Al2O3 support by microwave heating. The synthesis of NaA zeolite membrane in the microwave field only needs 15 min and the synthesis time is 10 times shorter than that by conventional heating. SEM characterization indicates that the zeolite crystals in the NaA zeolite membrane synthesized by microwave heating are uniform in size; the membrane thickness is about 4 μm and is thinner than that of the NaA zeolite membrane synthesized by conventional heating. Gas permeation studies indicate that the permeances of the NaA zeolite membrane synthesized by microwave heating are 3-4 times higher than those of the NaA zeolite membrane synthesized by conventional heating, while their permselectivities are comparable. | Xiaochun Xu Weishen Yang Jie Liu Liwu Lin | 2000 | Chinese Science Bulletin2000，45，13： | 2 |
| 7 | A numerical study of laminar natural convective heat transfer around a horizontal cylinder inside a concentric air-filled triangular enclosure显示文摘 | Xu Xu Zitao Yu Yacai Hu Liwu Fan Kefa Cen | 2009 | International Journal of Heat and Mass Transfer2009，，1： | 1 |
| 8 | Shape Selectivity in Methane Dehydroaromatization Over Mo/MCM-22 Catalysts During a Lifetime Experiment显示文摘 | J. Bai Shenglin Liu Sujuan Xie Longya Xu Liwu Lin | 2003 | Catalysis Letters (-)2003，，3： | 1 |
| 9 | Regeneration behaviors of Fe/Si‐2 and Fe–Mn/Si‐2 catalysts for C2H6 dehydrogenation with CO2 to C2H4显示文摘 | Longya Xu Jinxiang Liu Hong Yang Yide Xu Qingxia Wang Liwu Lin | 1999 | Catalysis Letters (-)1999，，2： | 1 |
| 10 | Au nanoring arrays as surface enhanced Raman spectroscopy substrate for chemical component study of individual atmospheric aerosol particle显示文摘Monolayer-ordered gold nanoring arrays were prepared by ion-sputtering method and used as surface enhanced Raman spectroscopy(SERS)substrates to test the individual atmospheric aerosols particle.Compared to other methods used for testing atmospheric aerosols particles,the collection and subsequent detection in our work is performed directly on the gold nanoring SERS substrate without any treatment of the analyte.The SERS performance can be tuned by changing the depth of the gold nanoring cavity as originating from coupling of dipolar modes at the inner and outer surfaces of the nanorings.The electric field exhibits uniform enhancement and polarization in the ordered Au nanoring substrate,which can improve the accuracy for detecting atmospheric aerosol particles.Combined with Raman mapping,the information about chemical composition of individual atmospheric aerosols particle and distribution of specific components can be presented visually.The results show the potential of SERS in enabling improved analysis of aerosol particle chemical composition,mixing state,and other related physicochemical properties. | Hanyun Cheng Xu Dong Yang Yang Yiqing Feng Tao Wang Muhammad Ali Tahir Liwu Zhang Hongbo Fu | 2021 | Journal of Environmental Sciences2021，33，2： | 1 |
| 11 | The Catalytic Dehydrogenation of c2h6 to c2h4 under non-Oxidative Conditions over the 6cr/g-al2o3Catalyst显示文摘 | Hong Yang Longya Xu Dechun Ji Qingxia Wang Liwu Lin | 2002 | Reaction Kinetics and Catalysis Letters2002，，1： | 1 |
| 12 | Significantly enhanced photocatalytic performance of ZnO via graphene hybridization and the mechanism study显示文摘 | Tongguang Xu Liwu Zhang Hanyun Cheng Yongfa Zhu | 2010 | Applied Catalysis B Environmental2010，，3： | 1 |
| 13 | Promotional effect of Pt on non-oxidative methane transformation over Mo-HZSM-5 catalyst显示文摘 | Laiyuan Chen Liwu Lin Zhusheng Xu Tao Zhang Xinsheng Li | 1996 | Catalysis Letters (-)1996，，3： | 1 |
| 14 | Synthesis of NaA zeolite membranes from clear solution显示文摘 | Xiaochun Xu Weishen Yang Jie Liu Liwu Lin | 2001 | Microporous and Mesoporous Materials2001，，3： | 1 |
| 15 | Reactions in a Mixture of CH_4 and CO_2 under the Action of Microwave Discharge at Atmospheric Pressure显示文摘Reactions between CH4 and CO2 under the action of continuous microwave discharge at atmospheric pressure were studied in a special homemade reactor,The main products were CO and H2,while acetylene and ethylene were also found in the products.Experimental results show that conversions of CH4 and CO2 could be higher than 90% without the presence of any catalyst,Effects of CO2/CH4 molar ratio and total flow rate of the feed gas on the reaction were also investigated. | Yunpeng Xu Zhijian Tian Zhusheng Xu Liwu Lin | 2002 | Journal of Natural Gas Chemistry2002，11，1： | 1 |
| 16 | Promotional effect of Pt on non-oxidative methane trans{ormation over Mo-HZSM-5 catalyst显示文摘 | Chen Laiyuan Lin Liwu Xu Zhusheng | 1996 | Catal Lett1996，39，2： | 1 |
| 17 | Coupled hydrogenation and ring opening of tetralin on potassium modified Pt/USY catalysts显示文摘 | Huaijun Ma Xiaomei Yang Guodong Wen Ge Tian Lei Wang Yunpeng Xu Bingchun Wang Zhijian Tian Liwu Lin | 2007 | Catalysis Letters (-)2007，，3： | 1 |
| 18 | Synthesis of NaA zeolite membrane with high performance显示文摘 | Xiaobo Chen Weishen Yang Jie Liu Xiaochun Xu Aisheng Huang Liwu Lin | 2002 | Journal of Materials Science Letters2002，，13： | 1 |
| 19 | Microwave-assisted hydrothermal synthesis of hydroxy-sodalite zeolite membrane显示文摘 | Xiaochun Xu Yun Bao Chunshan Song Weishen Yang Jie Liu Liwu Lin | 2004 | Microporous and Mesoporous Materials2004，，3： | 1 |
| 20 | Overexpression of UDP-glucose pyrophosphorylase gene could increase cellulose content in Jute ( Corchorus capsularis L.)显示文摘 | Gaoyang Zhang Jianmin Qi Jiantang Xu Xiaoping Niu Yujia Zhang Aifen Tao Liwu Zhang Pingping Fang LiHui Lin | 2013 | Biochemical and Biophysical Research Communications . 2013 (3-4)2013，，3： | 1 |
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