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| 1 | Wavelength and oscillator strength of dipole transition 1s^22p—1s^2nd for Mn^(22+) ion显示文摘The transition energies, wavelengths and dipole oscillator strengths of 1s22p-1s2nd (3≤n≤9) for Mn22+ ion are calculated. The fine structure splittings of 1s2nd (n≤9) states for this ion are also evaluated. In calculating energy, the higher-order relativistic contribution is estimated under a hydrogenic approximation. The quantum defect of Rydberg series 1s2nd is determined according to the quantum defect theory. The results obtained in this paper excellently agree with the experi-mental data available in literatures. | WANG ZhiWen, WANG YaNan, HU MuHong, LI XinRu & LIU Ying School of Physics and Electronic Technology, Liaoning Normal University, Dalian 116029, China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 8 |
| 2 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 3 | The silk in Worm History, and JOHN E. HILL, Through the Jade Gate to Rome. A Study of the Silk Routes during the Later Han Dinasty 1^st to 2^nd Centurtes CE (Juan Pablo Sanchez Hemandez)显示文摘 | XINRU LIU | 2010 | Journal of Ancient Civilizations2010，25，1： | 2 |
| 4 | Differential efficiency of a begomovirus to cross the midgut of different species of whiteflies results in variation of virus transmission by the vectors显示文摘Begomoviruses are important crop viral disease agents, and they are transmitted by whiteflies of the Bemisia tabaci complex.Although the transmission of begomoviruses by whiteflies has been studied for many years, the mechanisms governing differential transmission of begomoviruses by different species of the Bemisia tabaci complex remain largely unknown. Here we firstly compared the transmission efficiency of tobacco curly shoot virus(TbCSV) by four species of the B. tabaci complex and found that Asia II 1 transmitted this virus with the highest efficiency, whereas MEAM1 transmitted it with the lowest. Next, by performing quantitative analysis of virus and immune-fluorescence detection, we found that the efficiency of TbCSV to cross the midgut wall was higher in Asia II 1 than in MEAM1. Finally, we set the quantities of virions in the haemolymph to the same level in Asia II 1 and MEAM1 via injection and then compared their capacity in TbCSV transmission, and found that the difference in TbCSV transmission between them became smaller. Taken together, our findings suggest that the efficiency of a begomovirus to cross the midgut wall of a whitefly to reach the vector's haemolymph plays a significant role in determining transmission of the virus. | Lilong Pan Qunfang Chen Tao Guo Xinru Wang Ping Li Xiaowei Wang Shusheng Liu | 2018 | Science China(Life Sciences)2018，61，10： | 2 |
| 5 | Study on the demulsification of the oil-in-water emulsion from the column top of a delayed coking unit显示文摘 | Guiling Liu Xinru Xu Jinsheng Gao | 2004 | Petroleum Science and Technology2004，22，34： | 1 |
| 6 | Study on the demulsification of the oil-in-water emulsion from the column top of a delayed coking unit 显示文摘 | Xinru Xu Guiling Liu Yunming Yang | 2004 | Petroleum Science and Technology2004，22，34： | 1 |
| 7 | Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population显示文摘 | Jiaping Chen Yue Jiang Xiaoan Liu Zhenzhen Qin Juncheng Dai Guangfu Jin Hongxia Ma Shui Wang Xinru Wang Zhibin Hu Hongbing Shen | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
| 8 | Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics显示文摘Effective cancer treatment puts high demands for cancer theranostics.For cancer diagnostics,optical coherence tomography(OCT)technology(including photothermal optical coherence tomography(PT-OCT))has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes(such as temperature change for PT-OCT).In this report,redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent.Briefly,black phosphorus quantum dots(BPQDs)are incorporated into cysteine-based poly-(disulfide amide)(Cys-PDSA)to form stable and biodegradable nanoagent.The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles(NPs)as a novel contrast agent for high-resolution PT-OCT bioimaging.The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo.And the obtained NPs exhibit excellent near-infrared(NIR)photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform,with very low chemo drug dosage and side effects.Both of the polymer and BPQD are degradable,indicating this platform is a rare PT-OCT agent that is completely biodegradable.Overall,our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy. | Haolin Chen Zhiming Liu Bo Wei Jun Huang Xinru You Jingyang Zhang Zhiling Yuan Zhilie Tang Zhouyi Guo Jun Wu | 2021 | Bioactive Materials2021，6，3： | 1 |
| 9 | Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles显示文摘OBJECTIVE: To investigate the metabolic pathogenesis in subjects with subjective tinnitus(ST)having kidney deficiency pattern(KDP)(ST/KDP) in terms of Traditional Chinese Medicine.METHODS: Three groups of subjects, including healthy individuals, subjects with ST/KDP, and subjects who were healthy initially and then developed ST/KDP one year later(healthy → ST/KDP),were recruited for this study. Serum metabolic profiles of all subjects were analyzed using ultra-performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry. The metabolic characteristics of the ST/KDP subjects were determined, and the corresponding biomarkers were predicted. The metabolomics data from the healthy → ST/KDP subjects were collected for further verification.RESULTS: Twelve metabolites in the ST/KDP subjects were different from those of the healthy control subjects. Of these metabolites, according to the prediction, except for octanoic acid, other metabolites might characterize ST/KDP. Ten metabolites at the outcome ST/KDP stage were different from those at the initial(control) stage. Through the comparison of these metabolites with the predicted metabolites, five common metabolites, including upregulated glutamate, serotonin, oroticacid and 8-oxoguanine, as well as downregulated taurine, were found. These common metabolites were significantly associated with canonical pathways including calcium signaling, γ-aminobutyric acid(GABA) receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.CONCLUSION: The metabolic pathogenesis in ST/KDP subjects was characterized by upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, additionally, perturbations of calcium signaling, GABA receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling. | Tan Yong Shen Shanshan Guan Fulan He Bing Lu Cheng Xiao Cheng Jiang Miao Zhao Ning Li Li Cheng Shiping Zu Xianpeng Zhang Weidong Liu Xinru Lü Aiping | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 1 |
| 10 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 11 | Study on the deferrization and desalting for crude oil显示文摘 | Liu Guiling Xu Xinru Gao Jinsheng | 2004 | Energy & Fuels2004，18，4： | 1 |
| 12 | MG2C:a user-friendly online tool for drawing genetic maps显示文摘Genetic map is a linear arrangement of the relative positions of sites in the chromosome or genome based on the recombination frequency between genetic markers.It is the important basis for genetic analysis.Several kinds of software have been designed for genetic mapping,but all these tools require users to write or edit code,making it time-costing and difficult for researchers without programming skills to handle with.Here,MG2C,a new online tool was designed,based on PERL and SVG languages.Users can get a standard genetic map,only by providing the location of genes(or quantitative trait loci)and the length of the chromosome,without writing additional code.The operation interface of MG2C contains three sections:data input,data output and parameters.There are 33 attribute parameters in MG2C,which are further divided into 8 modules.Values of the parameters can be changed according to the users’requirements.The information submitted by users will be transformed into the genetic map in SVG file,which can be further modified by other image processing tools.MG2C is a user-friendly and time-saving online tool for drawing genetic maps,especially for those without programming skills.The tool has been running smoothly since 2015,and updated to version 2.1.It significantly lowers the technical barriers for the users,and provides great convenience for the researchers. | Jiangtao Chao Zhiyuan Li Yuhe Sun Oluwaseun Olayemi Aluko Xinru Wu Qian Wang Guanshan Liu | 2021 | Molecular Horticulture2021，1，1： | 1 |
| 13 | Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells显示文摘 | Zhong Li Jing Li Baoqing Mo Chunyan Hu Huaqing Liu Hong Qi Xinru Wang Jida Xu | 2008 | Cell Biology and Toxicology2008，，5： | 1 |
| 14 | Study on the compatibility of high -paraffin crude oil with electric desahing demulsifiers 显示文摘 | Liu Gulling Xu Xinru Gao Insheng | 2003 | Energy & Fuels2003，17，3： | 1 |
| 15 | Dionysus and drama in the Buddhist art of Gandhara显示文摘 | Pia Brancaccio Xinru Liu | 2009 | Journal of Global History2009，，4： | 1 |
| 16 | Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells显示文摘 | Xue-Jiao Yang Hui-Yuan Lu Zi-Yin Li Qian Bian Liang-Lin Qiu Zhong Li Qizhan Liu Jianmin Li Xinru Wang Shou-Lin Wang | 2012 | Toxicology2012，，3： | 1 |
| 17 | Theoretical Analysis of Annular Elliptic Finned Tube Evaporative Condenser Based on Field Measurement显示文摘In this article,a new evaporative condenser with an annular elliptic firmed tube heat exchanger that includes a round inner tube and elliptic outer finned tube was designed and analyzed.The refrigerant flows between the round inner tube and the elliptic outer tube,and it simultaneously exchanges heat with the cooling water in the inner tube,the spray water,and the cooling air flowing past the outer tube.Using field measurement for the traditional round finned tube evaporative condenser in the Futong Metro Station of Line 14 in Beijing,China,the theoretical heat transfer performance of the annular elliptic finned tube evaporative condenser was analyzed and simulated.Compared with a round finned tube heat exchanger,the heat exchange capacity of the annular elliptic finned tube increased by 2.34%to 9.28%;the total heat transfer coefficient increased by 47.42%,and the power consumption of the fan in the air-conditioning system with an annular elliptic finned tube heat exchanger decreased by 11.18%to 14.65%.Therefore,the energy-saving performance and the heat transfer performance of the new annular elliptic finned tube heat exchanger were enhanced compared to the round finned tube heat exchanger. | GU Yaxiu WANG Junwei WANG Xinru Ll Mohua PAN Song LIU Guangdong WANG Wentao GING Zexiang | 2020 | Journal of Thermal Science2020，29，5： | 1 |
| 18 | Study on the deferrization and desalting for crude oil显示文摘 | LIU Guiling XU Xinru GAO Jinsheng | 2004 | Energy Fuels2004，18，4： | 1 |
| 19 | Clinical practice guideline for body composition assessment based on upper abdominal magnetic resonance images annotated using artificial intelligence显示文摘Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fraction(PDFF)and the amount of abdominal adipose tissue during clinical evaluation and for research on obesity-related risks.Analytical results may be used to determine the optimal choice of surgical procedure and evaluate treatment outcomes.Multiple artificial intelligence(Al)algorithms and systems have been developed for the automated measurement of body composition.The basis of Al development and application is to have uniform standards for clinical data acquisition and management.The uneven quality ofMR images is one ofthe major obstacles to Al system development and analytical results.A standardized process of MR scanning and clinical data management is urgently needed. | Han Lv Mengyi Li Zhenchang Wang Dawei Yang Hui Xu Juan Li Yang Liu Di Cao Yawen Liu Xinru Wu He Jin Peng Zhang Liqin Zhao Rixing Bai Yunlong Yue Bin Li Nengwei Zhang Mingzhu Zou Jinghai Song Weibin Yu Pin Zhang Weijun Tang Qiyuan Yao Liheng Liu Hui Yang Zhenghan Yang Zhongtao Zhang National Clinical Research Center for Digestive Diseases in Beijing Friendship Hospital,Capital Medical University Beijing Quality Control and Improvement Center of Medical Imaging National Health Commission Capacity Building and Continuing Education Center,Chinese College of Metabolic and Bariatric Surgeons Beijing Quality Control and Improvement Center of Metabolic and Bariatric Surgery | 2022 | Chinese Medical Journal2022，，6： | 1 |
| 20 | One- Step Fabrication and Analysis of an Asymmetric Cellulose Acetate Membrane for Heat and Moisture Recovery 显示文摘 | ZHANG XinRu Zhang LiZhi LiU HongMei | 2011 | Journal of Membrane Science2011，366，12： | 1 |
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