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| 1 | Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer显示文摘Obesity is a global pandemic characterized by high levels of body fat(adiposity) and derived-cytokines(i.e., leptin). Research shows that adiposity and leptin provide insight on the link between obesity and cancer progression. Leptin's main function is to regulate energy balance. However, obese individuals routinely develop leptin resistance, which is the consequence of the breakdown in the signaling mechanism controlling satiety resulting in the accumulation of leptin. Therefore, leptin levels are often chronically elevated in human obesity. Elevated leptin levels are related to higher incidence, increased progression and poor prognosis of several human cancers. In addition to adipose tissue, cancer cells can also secrete leptin and overexpress leptin receptors. Leptin is known to act as a mitogen, inflammatory and pro-angiogenic factor that induces cancer cell proliferation and tumor angiogenesis. Moreover, leptin signaling induces cancer stem cells, which are involved in cancer recurrence and drug resistance. A novel and complex signaling crosstalk between leptin, Notch and interleukin-1(IL-1) [Notch, IL-1 and leptin crosstalk outcome(NILCO)] seems to be an important driver of leptin-induced oncogenic actions. Leptin and NILCO signaling mediate the activation of cancer stem cells that can affect drug resistance. Thus, leptin and NILCO signaling are key links between obesity and cancer progression. This review presents updated data suggesting that adiposity affects cancer incidence, progression, and response to treatment. Here we show data supporting the oncogenic role of leptin in breast, endometrial, and pancreatic cancers. | Crystal C Lipsey Adriana Harbuzariu Danielle Daley-Brown Ruben R Gonzalez-Perez | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 2 | Diagnosis and clinical mangement of past- stroke depression显示文摘 | Robinson RG Lipsey JR Price TR | 1985 | Psyehosomatics1985，26，10： | 1 |
| 3 | Foreign Production and Export in Manufacturing Industuries显示文摘 | Lipsey Weiss | 1981 | Review of Ecomomic and Statistics1981，，66： | 1 |
| 4 | The impact of post-stroke depression on recovery in activities of daily living over two years follow-up显示文摘 | Parikh RM Robinson RG Lipsey JR | 1990 | Arch Neurol1990，47，： | 1 |
| 5 | Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis显示文摘 | Ozer E J Best SR Lipsey TL | 2003 | Psychol Bull2003，129，1： | 1 |
| 6 | The impact of poststroke depression on recovery in activities of daily living over two years follow - up 显示文摘 | Parikh RM Robinson RC Lipsey JR | 1990 | Arch Neurol1990，47，： | 1 |
| 7 | Nortriptyline treatment of post-stroke depression:A double-blind study显示文摘 | Robinson R Pearlson G | 1984 | Lancet1984，1，： | 1 |
| 8 | Depression, antide- pressants, and bone health in older adults: a systematic review 显示文摘 | Gebara MA Shea ML Lipsey KL | 2014 | J Am Geriatr Soc2014，62，8： | 1 |
| 9 | Foreign Direct Investment,Education and Wages in Indonesian Manufacturing显示文摘 | Lipsey R.E Sjoholmb F | | 0，，01： | 1 |
| 10 | The General Theory of the Second Best显示文摘 | Richard Lipsey Kevin Lancaster | 1956 | Review of Economic Studies1956，，24： | 1 |
| 11 | Frequecy of depression following stroke显示文摘 | Robinson RG Lipsey JR | 2005 | Stroke2005，36，： | 1 |
| 12 | Two-year longitudinal study of post-stroke mood disorders:comparison of acuteonset with delayed-onset depression显示文摘 | Robinson RGI Lipsey JR Rao K | 1986 | Am J Psychiatry1986，143，10： | 1 |
| 13 | Predictors of posttaumatic stree disorder and sympotoms in adults:a meta ananlysis显示文摘 | Ozer E J Best S R Lipsey T L | 2003 | Psychol Bull2003，129，1： | 1 |
| 14 | The theory of market pre-emption: The persistence of excess capacity and monopoly in growing spatial markets显示文摘 | Eaton B C Lipsey R G | 1979 | Economica1979，46，2： | 1 |
| 15 | The General theory of second best 显示文摘 | LIPSEY R G LANCASTER K | 1956 | Review of Economic Studies1956，24，1： | 1 |
| 16 | The theory of market preemption:the persistence of excess capacity and monopoly in growing spatial markets显示文摘 | LIPSEY R G | 1979 | Econometrica1979，，： | 1 |
| 17 | Wages and Foreign Ownership: A Comparative Study of Mexico, Venezuela, and the United States显示文摘 | Atiken B J Harrison A E Lipsey R E | 1996 | Journal of International Economics1996，40，34： | 1 |
| 18 | Exit barriers and entry barriers:the durability of capital as barrier to entry显示文摘 | LIPSEY R G | 1980 | Bell Journal of Economics1980，，： | 1 |
| 19 | The impact of poststroke depression on recovery in activities of daily living over a 2-year followup显示文摘 | Robinson RG Lipsey JR | 1990 | Arch Neurol1990，47，7： | 1 |
| 20 | Export Prices and the Transmission of Inflation显示文摘 | Kravis I B Lipsey R E | 1977 | The American Economic Review1977，67，1： | 1 |
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