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| 1 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Substance P and Substance P receptor antagonists in the pathogenesis and treatment of affective disorders显示文摘 | Herpfer I Lieb K | 2003 | World J Biol Psychiatry2003，4，2： | 1 |
| 3 | Substance P receptorantagonists-a new antide-pressive and anxiolyric mechanism?显示文摘 | Lieb K Fiebicl BI Berger M | 2000 | Nervenarzt2000，71，9： | 1 |
| 4 | Oxidation of thin CrN and Cr2N films analyzed via nuclear reaction analysis and Rutherford backscattering spectrometry 显示文摘 | KACSICH T LIEB K P | 1994 | Thin Solid Films1994，245，12： | 1 |
| 5 | Oxidation of thin CrN and Cr2N films analyzed via nuclear reaction analysis and Rutherford backs scattering 显示文摘 | Kacsich T Lieb K P | 1994 | Thin Solid Films1994，235，： | 1 |
| 6 | Immortalized liver endothelial ceils: a cell culture model for studies of motility and angiogenesis 显示文摘 | Huebert R C Jagavelu K Lieb A F | 2010 | Lab Invest2010，90，12： | 1 |
| 7 | Pharmacotherapy for borderline personality disorder:Cochrane systematic review ofrandomised trials显示文摘 | Lieb K V(o)lm B Rücker G | 2010 | Br J Psychiatry2010，196，： | 1 |
| 8 | Serum levels of substance P and response to antidepressant pharmacotherapy显示文摘 | Lieb K Walden J Grunze H | 2004 | Pharmacopsychiatry2004，37，5： | 1 |
| 9 | The non - steroidal anti -inflammatory drug tepoxalin inhibit s interleukin -6 and alpha 1 antichymotrypsin synthesis in astrocytes by preventing degradationof I kappa B - alpha 显示文摘 | FIEBICH B L HOFER T J LIEB K | 1999 | Neuropharmacology1999，38，9： | 1 |
| 10 | Microglia:mechanisms of activation and significance in pathogenesis of neuropsychiatric illnesses显示文摘 | Gebicke-Haerter PJ Lieb K Illes P | 1998 | Nervenarzt1998，69，9： | 1 |
| 11 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 12 | Substance P and Substancen P receptor antagonists in the pathogenesis and neat to affective disorders显示文摘 | Herpfer I Lieb K | 2003 | World J Biol Psychiatry2003，4，2： | 1 |
| 13 | Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder显示文摘 | Beesdo K Pine DS Lieb R | 2010 | Arch Gen Psychiatry2010，67，： | 1 |
| 14 | Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder显示文摘 | Beesdo K Pine D S Lieb R | 2010 | Arch Gen Psychiatry2010，67，1： | 1 |
| 15 | Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs显示文摘 | Hull M Lieb K Fiebich BL | 2002 | Curr Med Chem2002，9，1： | 1 |
| 16 | Sleep deprivation and growth-hormone secretion 显示文摘 | Lieb K Reineke M Riemann D | 2000 | Lancet2000，356，9247： | 1 |
| 17 | Cognitive impair- ment in patients with chronic hepatitis treated with interferon al- pha (IFNalpha) : results from a prospective study显示文摘 | LIEB K ENGELBRECHT MA GUT O | 2006 | Eur Psy- chiatry2006，21，3： | 1 |
| 18 | 显示文摘 | Neubauer M Lieb K P | 1998 | J Alloys Compounds1998，274，： | 1 |
| 19 | 显示文摘 | Niederdrenk M Schaaf P Lieb K P | 1996 | J Alloy Comp1996，237，： | 1 |
| 20 | Substance P and Substance P receptor antagonists in the pathogenesis and treatment of affective disorders显示文摘 | Herpfer I Lieb K | 2003 | Wodd J Biol Psychiatry2003，4，2： | 1 |
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