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| 1 | Full-thickness tissue engineered skin constructed with autogenic bone marrow mesenchymal stem cells显示文摘To explore the feasibility of repairing clinical cutaneous deficiency, autogenic bone marrow mesen-chymal stem cells (BMSCs) were isolated and differentiated into epidermal cells and fibroblasts in vitro supplemented with different inducing factors and biomaterials to construct functional tissue- engineered skin. The results showed that after 72 h induction, BMSCs displayed morphologic changes such as typical epidermal cell arrangement, from spindle shape to round or oval; tonofibrils, melano-somes and keratohyaline granules were observed under a transmission electronic microscope. The differentiated cells expressed epidermal stem cell surface marker CK19 (59.66% ± 4.2%) and epidermal cells differentiation marker CK10. In addition, the induced epidermal cells acquired the anti-radiation capacity featured by lowered apoptosis following exposure to UVB. On the other hand, the collagen microfibrils deposition was noticed under a transmission electronic microscope after differentiating into dermis fibroblasts; RT-PCR identified collagen type I mRNA expression in differentiated cells; radioimmunoassay detected the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) (up to 115.06 pg/mL and 0.84 ng/mL, respectively). Further in vivo implanting BMSCs with scaffold material short-ened skin wound repair significantly. In one word, autogenic BMSCs have the potential to differentiate into epidermal cells and fibroblasts in vitro, and show clinical feasibility acting as epidermis-like and dermis-like seed cells in skin engineering. | HE LiJuan, NAN Xue, WANG YunFang, GUAN LiDong, BAI CiXian, SHI ShuangShuang, YUAN HongFeng, CHEN Lin, LIU DaQing & PEI XueTao Laboratory of Stem Cells and Regenerative Medicine, Institute of Blood Transfusion, Academy of Military Medical Sciences, Beijing 100850, China | 2007 | Science China(Life Sciences)2007，50，4： | 16 |
| 2 | Human papillomavirus DNA and P16~(INK4A) expression in concurrent esophageal and gastric cardia cancers显示文摘AIM:To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16 INK4A protein expression.METHODS:Polymerase chain reaction was used to detect the presence of HPV type16 (HPV16).The expression of P16 INK4A protein was detected using immunohistochemistry.RESULTS:Among the CC specimens,HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA),respectively (47% vs 29%),and two of both ESCC and GCA.P16 INK4A was highly expressed in both ESCC and GCA.In the HPV-associated positive CC,higher P16 INK4A expression was observed in the GCA than in the ESCC (75% vs 25%,P < 0.05).CONCLUSION:HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA.P16 INK4A may be a screening index in the HPVassociated carcinoma of gastric cardia. | Guang-Cheng Ding,Tao Guo,Department of Gastroenterology,The First Affiliated Hospital and The Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,Henan Province,China Jing-Li Ren,Xin Song,Sheng-Li Zhou,Zong-Min Fan,LiDong Wang,Henan Key Laboratory for Esophageal Cancer Research,Department of Gastroenterology,The First Affiliated Hospital,College of Basic Medicine,Zhengzhou University,Zhengzhou 450052,Henan Province,China Fu-Bao Chang,Department of Thoracic Surgery,Linzhou Center Hospital,Linzhou 456500,Henan Province,China Ji-Lin Li,Department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456500,Henan Province,China Ling Yuan,Department of Oncoradiotherapy,Henan Province Tumor Hospital,Zhengzhou 450003,Henan Province,China Yi Zeng,Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 3 | Experimental and mechanism studies on simultaneous desulfurization and denitrification from flue gas using a flue gas circulating fluidized bed显示文摘The oxidizing highly reactive absorbent was prepared from fly ash,industry lime,and an oxidizing additive M.Experiments of simultaneous desulfurization and denitrification were carried out in a flue gas circulating fluidized bed(CFB).The effects of influencing factors and calcium availability were also investigated on the removal efficiencies of desulfurization and denitrification.Removal efficiencies of 95.5%for SO2 and 64.8%for NO were obtained respectively under the optimal experimental conditions. The component of the spent absorbent was analyzed with chemical analysis methods.The results in- dicated that more nitrogen species appeared in the spent absorbent except sulfur species.A scanning electron microscope(SEM)and an accessory X-ray energy spectrometer were used to observe micro-properties of the samples,including fly ash,oxidizing highly reactive absorbent and spent absorbent.The simultaneous removal mechanism of SO2 and NO based on this absorbent was pro- posed according to the experimental results. | ZHAO Yi XU PeiYao SUN XiaoJun WANG LiDong | 2007 | Science China Chemistry2007，50，1： | 10 |
| 4 | Precious Fossil-Bearing Beds of the Lower Cretaceous Jiufotang Formation in Western Liaoning Province, China显示文摘在西方的辽宁基于分进更低的白垩纪 JiufotangFormation 的三个成员,这篇论文主要处理宝贵石块鸟的部门和关联 -- 并且在 Dachengzi, Chaoyang, Dapingfang-Meileyingzi 和 Fuxin-Yixian 的形成的忍受爬行动物的床盆。在他们之中,在 theDachengzi 盆的宝贵的忍受石块的床可以作为第二个成员的 Xidagou 床和第三个成员的 YangcaogoudonggouBed 被认出;那些可以作为第二个成员的 Shangheshou 床和第三个成员的 Dongpochi 床在 Chaoyang 盆被证实;那些在 Dapingfang-Meileyingzi Basinare 作为第二个成员,的 Lamagou 床 Huanghuagou 床更低第三张成员和 theYuanjiawa 床上面第三个成员;并且那些作为第二个成员的 theTuanshanzi 床和第三个成员的 Pijiagou 床在 Fuxin-Yixian 盆被列出。因为这些盆清楚地被分开,鸟和爬行动物石块主要是新类和种,我们有篷乱是的联系石块 ostracod 集合相关,并且相关的索引有 theShangheshou 床的 Xidagou 床和 Lamagou 床有 YangcaogoudonggouBed 的 Yuanjiawa 床和 Pijiagou 床。首先,我们在西方的辽宁建立了 Jiufotang 形成的宝贵的忍受石块的床的顺序。他们被代表由在登上顺序,第二个成员,的 theXidagou 床 Huanghuagou 床更低第三个成员,和 YuanjiawaBed 上面第三个成员。显然,这个工作在中间的早白垩纪的时期期间在鸟和恐龙的 time-spacedistribution 和放射上为学习有意义。 | ZHANG Lijun YANG Yajun ZHANG Lidong GUO Shengzhe WANG Wuli ZHENG Shaolin | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 9 |
| 5 | Transitivity, mixing and chaos for a class of set-valued mappings显示文摘Consider the continuous map f: X → X and the continuous map (f-) of K(X)into itself induced by f, where X is a metric space and K(X) the space of all non-empty compact subsets of X endowed with the Hausdorff metric. According to the questions whether the chaoticity of f implies the chaoticity of (f-) posed by Román-Flores and when the chaoticity of f implies the chaoticity of (f-)posed by Fedeli,we investigate the relations between f and (f-) in the related dynamical properties such as transitivity, weakly mixing and mixing etc.And by using the obtained results,we give the satisfied answers to Román-Flores's question and Fedeli's question. | LIAO Gongfu, WANG Lidong & ZHANG Yucheng Institute of Mathematics, Jilin University, Changchun 130012, China Institute of Nonlinear Information Technology, Dalian Nations University, Dalian 116600, China Department of Mathematics, University of Science and Technology of China, Hefei 230026, China | 2006 | Science China Mathematics2006，49，1： | 8 |
| 6 | Preparation of nano-sized Bi_2Te_3 thermoelectric material powders by cryogenic grinding | Xiaozong Chen a, Leifeng Liu b, Yuan Dong a, Lianjun Wang a, Lidong Chen c, Wan Jiang a, a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 people of North Road, Shanghai 201620, PR China b Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden c Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, PR China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 8 |
| 7 | Methane aromatization in the absence of oxygen over extruded and molded MoO_3/ZSM-5 catalysts:Influences of binder and molding method显示文摘The influences of binder and molding method on the catalytic performance of methane aromatization in the absence of O2 over MoO3/ZSM-5 catalysts were investigated.SEM,NH3-TPD,FT-IR of adsorbed pyridine,N2 adsorption-desorption,cyclohexane adsorption and XPS were employed to characterize the physical and chemical properties of the catalysts.It was found that SiO2 was a suitable binder for the catalyst due to its appropriate weak acidity.The laminar catalyst comprising of an inert spherical core and a MoO3/ZSM-5 laminar shell with 0.1 0.2 mm in thickness showed a better catalytic performance than the extruded catalyst.The improved activity of the laminar catalyst could be attributed to the easy carbonization of Mo species and the quick removal of reaction products from the catalyst surface. | Dongmei Ren Xiangsheng Wang Gang Li Xiaojing Cheng Huayun Long Lidong Chen | 2010 | Journal of Natural Gas Chemistry2010，19，6： | 7 |
| 8 | Electroacupuncture diminishes P2X_2 and P2X_3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity显示文摘Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia. | Zhijun Weng Luyi Wu Yuan Lu Lidong Wang Linying Tan Ming Dong Yuhu Xin | 2013 | Neural Regeneration Research2013，8，9： | 7 |
| 9 | A class of primitive substitutions and scrambled sets显示文摘Consider the subshifts induced by constant-length primitive substitutions on two symbols. By investigating the equivalent version for the existence of Li-Yorke scrambled sets and by proving the non-existence of Schweizer-Smítal scrambled sets, we completely reveal for this class of subshifts the chaotic behaviors possibly occurring in the sense of Li-Yorke and Schweizer-Smítal. | LIAO GongFu FAN QinJie WANG LiDong | 2008 | Science China Mathematics2008，51，3： | 7 |
| 10 | Early Uplift History of the Tibetan Plateau:Records from Paleocurrents and Paleodrainage in the Hoh Xil Basin显示文摘摘要:在领域工作收集的 Paleocurrent 指示物数据被用来在北西藏的高原在 Hoh Xil 盆学习早新生代地区性的 paleodrainage 模式。paleocurrent 方向始新世 Fenghuoshan 组显然证明流动是向北方与一个单向性的疏开模式。这可能在起始的盆免职时期期间反映 Qiangtang 地面的 uplift 并且显示 Tanggula Moutains 在至少作为地志的高地发生了始新世。渐新世 Yaxicuo 组的 Paleoflows 对北方主导地面向然后在它的迟了的免职期间向东流动了。Yaxicuo 组的 paleodrainage 模式的这地区性的可变性被解释从横向的河记录沉积的疏开风格到纵的河系统。渐新世山妨碍了由的 Kunlun 高举,这被推断向北方,到 orogenic 的 paleoflows 和创造的纵的河系统平行系上带子。paleodrainage 模式的时间、空间的变化建议西藏的高原的北边界在早新生代期间位于 Hoh Xil 区域,它的 uplift 整个时间向北进行了。 | YI Haisheng WANG Chengshan SHI Zhiqiang LIN Jinhui ZHU Lidong | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 7 |
| 11 | Effect of Ball Milling on the Defeat of Few-Layer Graphene and Properties of Copper Matrix Composites显示文摘Graphene-reinforced copper composites recently have attracted more attention, since they exhibited excellent mechanical properties and could be used widely in many fields. Few-layer graphene(FLG) and copper powder were mixed by ball milling to produce homogeneous composite powders. Then, FLG-reinforced copper composites(FLG/Cu) were fabricated by spark plasma sintering(SPS) using the composite powders with a FLG volume fraction of 2.4 vol%. The effects of the rotating speed and the time of ball milling were analyzed based on the microstructure evolution and properties of the FLG/Cu composites. Obvious strengthening effect of FLG was found for the composites, and the conductance of the composite reaches 70.4% of IACS. The yield strength of the composite produced by ball milling at a speed of 100 r/min for 4 h is 376 MPa, which is 2.5 times higher than that of copper and higher than that of copper composite enhanced by 5 vol% CNTs(360 MPa). The defects produced in FLG with the increase of rotating speed and time could reduce the mechanical and conductive properties of the composites. | Ye Cui Lidong Wang Bin Li Guojian Cao Weidong Fei | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 6 |
| 12 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 13 | Solute-homogenization model and its experimental verification in Mg-Gd-based alloys显示文摘Composition homogenization in solid solution is important for industrial alloys. In the present work, a solute homogenization model is proposed based on the chemical short-range-order tendency in Mg-Gdbased alloys. After a calculation using the cluster-plus-glue-atom model, the stable Mg-Gd structural unit is derived, [Gd-Mg12]Mg6, where one solute Gd is nearest-neighbored with twelve Mg atoms to form the characteristic hcp cluster [Gd-Mg12] and this cluster is matched with six Mg glue atoms. Such a local unit is then mixed with [Mg-Mg12]Mg3, the stable unit for pure Mg. Assuming that the Gd-containing units are arranged in fcc-or bcc-like lattice points and the Mg units in their octahedral interstices, three proportions between the two units are obtained, 1:1, 2:3, and 1:3, which constitute three solute homogenization modes. The prevailing Mg-Gd-based alloys are consequently classified into three groups, respectively exemplified by GW103 K(Mg-10 Gd-3 Y-0.4 Zr, wt%), GW83 K(Mg-8 Gd-3 Y-0.4 Zr), and GW63 K(Mg-6 Gd-3 Y-0.4 Zr). Mg-Gd-Y-Zr alloys were designed following the model(where Y and Zr were also added in substitution for Gd) and prepared by permanent-mould casting. According to their mechanical properties,the 1:3 alloy(Mg-5.9 Gd-1.6 Y-0.4 Zr) shows the best comprehensive properties(ultimate tensile strength305 MPa, yield strength 186 MPa, elongation 9.0%) in solution plus ageing state. | Shengnan Qian Chuang Dong Tianyu Liu Ying Qin Qing Wang Yujuan Wu Lidong Gu Jianxin Zou Xiangwen Heng Liming Peng Xiaoqin Zeng | 2018 | Journal of Materials Science & Technology2018，34，7： | 6 |
| 14 | In vitro differentiation of human adipose-derived mesenchymal stem cells into endothelial-like cells显示文摘The neovascularization of ischemic tis- sue is a crucial initial step for the functional rehabili- tation and wound healing. However, the short of seed cell candidate for the foundation of vascular network is still a big issue. Human adipose tissue derived mesenchymal stem cells (hADSCs), which possess multilineage potential, are capable of adipogenic, osteogenic, and chondrogenic differentiation. We examined whether this kind of stem cells could dif- ferentiate into endothelial-like cells and participate in blood vessel formation, and whether they could be used as an ideal cell source for therapeutic angio- genesis in ischemic diseases or vascularization of tissue constructs. The results showed that hADSCs, grown under appropriately induced conditions, dis- played characteristics similar to those of vessel en- dothelium. The differentiated cells expressed endo- thelial cell markers CD34 and vWF, and had high metabolism of acetylated low-density lipoprotein and prostacyclin. In addition, the induced cells were able to form tube-like structures when cultured on matrigel. Our data indicated that induced hADSCs could ex- hibit characteristics of endothelial cells. Therefore, these cells, as a source of human endothelial cells, may find many applications in such realms as engi- neering blood vessels, endothelial cell transplantation for myocardial regeneration, and induction of angio- genesis for treatment of regional ischemia. | GUAN Lidong LI Shaoqing WANG Yunfang YUE Huimin LIU Daqing HE Lijuan BAI Cixian YAN Fang NAN Xue SHI Shuangshuang PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，15： | 6 |
| 15 | Mechanism of flue gas simultaneous desulfuri-zation and denitrification using the highly reactive absorbent显示文摘Fly ash, industry-grade lime and a few oxidizing manganese compound additive were used to prepare the “Oxygen-riched” highly reactive absorbent for simultaneous desulfurization and denitrification. Experiments of simultaneous desulfurization and denitrification were carried out using the highly reactive absorbent in the flue gas circulating fluidized bed (CFB) system. Removal efficiencies of 94.5% for SO2 and 64.2% for NO were obtained respectively. The scanning electron microscope (SEM) and accessory X-ray energy spectrometer were used to observe micro-properties of the samples, including fly ash, common highly reactive absorbent, “Oxygen-riched” highly reactive absorbent and spent absorbent. The white flake layers were observed in the SEM images about surfaces of the common highly reactive absorbent and “Oxygen- riched” one, and the particle surfaces of the spent absorbent were porous. The content of calcium on surface was higher than that of the average in the highly reactive absorbent. The manganese compound additive dispersed uniformly on the surfaces of the “Oxygen- riched” highly reactive absorbent. There was a sulfur peak in the energy spectra pictures of the spent absorbent. The component of the spent absorbent was analyzed with chemical analysis methods, and the results indicated that more nitrogen species appeared in the absorbent except sulfur species, and SO2 and NO were removed by chemical absorption according to the experimental results of X-ray energy spectrometer and the chemical analysis. Sulfate being the main desulfurization products, nitrite was the main denitrification ones during the process, in which NO was oxidized rapidly to NO2 and absorbed by the chemical reaction. | ZHAO Yi SUN Xiaojun XU Peiyao MA Shuangchen WANG Lidong LIU Feng | 2005 | Science China(Technological Sciences)2005，48，6： | 5 |
| 16 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 17 | Concept of the solar ring mission:An overview显示文摘The concept of the Solar Ring mission was gradually formed from L5/L4 mission concept, and the proposal of its pre-phase study was funded by the National Natural Science Foundation of China in November 2018 and then by the Strategic Priority Program of Chinese Academy of Sciences in space sciences in May 2019. Solar Ring mission will be the first attempt to routinely monitor and study the Sun and inner heliosphere from a full 360-degree perspective in the ecliptic plane. The current preliminary design of the Solar Ring mission is to deploy six spacecraft, grouped in three pairs, on a sub-AU orbit around the Sun. The two spacecraft in each group are separated by about 30?and every two groups by about 120?. This configuration with necessary science payloads will allow us to establish three unprecedented capabilities:(1) determine the photospheric vector magnetic field with unambiguity,(2) provide 360-degree maps of the Sun and the inner heliosphere routinely, and(3) resolve the solar wind structures at multiple scales and multiple longitudes. With these capabilities, the Solar Ring mission aims to address the origin of solar cycle, the origin of solar eruptions, the origin of solar wind structures and the origin of severe space weather events. The successful accomplishment of the mission will advance our understanding of the star and the space environment that hold our life and enhance our capability of expanding the next new territory of human. | WANG YuMing JI HaiSheng WANG YaMin XIA LiDong SHEN ChengLong GUO JingNan ZHANG QuanHao HUANG ZhengHua LIU Kai LI XiaoLei LIU Rui WANG JingXiu WANG Shui | 2020 | Science China(Technological Sciences)2020，63，9： | 4 |
| 18 | Loss of gonadal soma derived factor damaging the pituitary-gonadal axis in medaka显示文摘Medaka sex is determined by dmy/dmrt1b Y,the doublesex and mab-3 domain gene on the Y chromosome[1,2].Most recent studies have revealed a germ cell-intrinsic cue for the sperm-egg fate decision present in medaka,leading to spermatogenesis occurrence in a female gonadal environment without the presence of dmy[3].Targeted disruption of dmy,or sex related genes,such | Kaiqing Sun Lidong Fan Chuanyun Wang Xiaoyu Yang Shuangguang Zhu Xi Zhang Xiaowu Chen Yunhan Hong Guijun Guan | 2017 | Science Bulletin2017，62，3： | 4 |
| 19 | Assessment of potential dermal and inhalation exposure of workers to the insecticide imidacloprid using whole-body dosimetry in China显示文摘In China, although improvements to the pesticide registration process have been made in la thirty years, no occupational exposure data are required to obtain a commercial license for pesticide product. Consequently, notably little research has been conducted to establish a exposure assessment procedure in China. The present study monitored the potential derm operator exposure from knapsack electric sprayer wheat field application of imidacloprid Liaocheng City, Shandong Province and in Xinxiang City, Henan Province, China, usin whole-body dosimetry. The potential inhalation exposure was determined using a person air pump and XAD-2 sample tubes. The analytical method was developed and validate including such performance parameters as limits of detection and quantification, linear rang recovery and precision. The total potential dermal and inhalation exposures were 14.20, 16.815.39 and 20.78 m L/hr, respectively, for the four operators in Liaocheng and Xinxian corresponding to 0.02% to 0.03% of the applied volume of spray solution. In all trials, the low part(thigh, lower leg) of the body was the most contaminated, accounting for approximate76% to 88% of the total exposure. The inhalation exposure was less than 1% of the tot exposure. Such factors as the application pattern, crop type, spray equipment, operat experience and climatic conditions have been used to explain the exposure distribution ov the different parts of the body. As indicated by the calculated Margin of Exposure, the typic wheat treatment scenarios when a backpack sprayer was used are considered to be safe terms of imidacloprid exposure. | Lidong Cao Bo Chen Li Zheng Dongwei Wang Feng Liu Qiliang Huang | 2015 | Journal of Environmental Sciences2015，27，1： | 4 |
| 20 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
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