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| 1 | Blockade of NF-κB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in rats显示文摘 | Shumei Li Shishun Zhong Kai Zeng Yukun Luo Feilong Zhang Xudong Sun Lianglong Chen | 2010 | Basic Research in Cardiology2010，，1： | 1 |
| 2 | Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients显示文摘 | Lingzhen Wu Jun Fang Lianglong Chen Ziwen Zhao Yukun Luo Chaogui Lin Lin Fan | 2014 | Clinical Chemistry and Laboratory Medicine2014，，： | 1 |
| 3 | Senescence in chronic wounds and potential targeted therapies显示文摘Chronic wounds(e.g.diabetic wounds,pressure wounds,vascular ulcers,etc.)do not usually heal in a timely and orderly manner but rather last for years and may lead to irreversible adverse events,resulting in a substantial financial burden for patients and society.Recently,a large amount of evidence has proven that cellular senescence has a crucial influence on chronic nonhealing wounds.As a defensive mechanism,cell senescence is a manner of cell-cycle arrest with increased secretory phenotype to resist death,preventing cells from stress-induced damage in cancer and noncancer diseases.A growing amount of research has advanced the perception of cell senescence in various chronic wounds and focuses on pathological and physiological processes and therapies targeting senescent cells.However,previous reviews have failed to sum up novel understandings of senescence in chronic wounds and emerging strategies targeting senescence.Herein,we discuss the characteristics and mechanisms of cellular senescence and the link between senescence and chronic wounds as well as some novel antisenescence strategies targeting other diseases that may be applied for chronic wounds. | Xuerong Wei Minxiong Li Zijun Zheng Jun Ma Yanbin Gao Lianglong Chen Yujie Peng Shengxiang Yu Lei Yang | 2022 | Burns & Trauma2022，10，1： | 1 |
| 4 | Enhanced therapeutic effects of mesenchymal stem cells on myocardial infarction by ischemic postconditioning through paracrine mechanisms in rats显示文摘 | Jun Fang Lianglong Chen Lin Fan Liming Wu Xiangqi Chen Weiwei Li Yunling Lin Weiwei Wang | 2011 | Journal of Molecular and Cellular Cardiology2011，，5： | 1 |
| 5 | Blockade of NF-κB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in rats显示文摘 | Shumei Li Shishun Zhong Kai Zeng Yukun Luo Feilong Zhang Xudong Sun Lianglong Chen | 2010 | Basic Research in Cardiology2010，，1： | 1 |
| 6 | Regulatory T cells contribute to rosuvastatin-induced cardioprotection against ischemia-reperfusion injury显示文摘 | Dan Ke Jun Fang Lin Fan Zhaoyang Chen Lianglong Chen | 2013 | Coronary Artery Disease2013，，： | 1 |
| 7 | Necessity and proper way of intermediate kissing balloon dilation for culotte stenting: further insights from bench testing显示文摘Objective: The aim of this study was to investigate whether intermediate kissing balloon dilation(IKBD) is necessary during mini-culotte stenting(MCS) and how it can be properly conducted. Methods: MCS was emulated in a bifurcation model with a branch diameter difference(BDD) in three-step sizes of 0.50, 0.75 and 1.00 mm, and with intermediate balloon dilation(IBD) in three treatments of routine intermediate solo balloon dilation(rISBD), concurrent IKBD(cIKBD) or sequential IKBD. Microcomputed tomography was performed to assess stent under-expansion(SUE) around the polygon of confluence(POC), residual ostial stenosis(ROS) at the ostial side-branch(SB) and main-branch(MB) and stent cell distortion(SCD) in the bifurcation segments. Results: There were both main and interactive effects of IBD and BDD on ROS at the ostial SB and SCD in the ostial SB, but there were only main effects of IBD or BDD on SUE around the POC, ROS at the ostial MB and SCD in the ostial MB. Analysis of the main effects showed that SUE around the POC or ROS at the ostial SB was significantly different between sI KBD and rISBD and between cI KBD and rISBD. There was also a significant difference in SCD in the ostial SB between sI KBD and rI SBD and between sI KBD and cIKBD. Analysis of the interactive effects showed that ROS at the ostial SB or SCD in the ostial SB was affected by all IBD treatments in all BDD step-sizes. Moreover, increasing the BDD step-sizes significantly increased ROS at the ostial SB as treated by rISBD and SCD in the ostial SB as treated by rISBD or cIKBD. Conclusions: SIKBD was shown to be essential and superior to rISBD or cIKBD, resulting in better bifurcated stent expansion and coverage when using MCS. | Wei Cai Lianglong Chen Linlin Zhang Zhixiong Wei Sheng Tu Lin Fan | 2018 | Journal of Interventional Medicine2018，1，4： | 0 |
| 8 | Immediate and mid-term outcomes of drug-eluting stent in treatment of coronary artery stenosis with very long defuse lesions显示文摘Objectives To evaluate the feasibility, and immediate and mid-term outcomes of drug-eluting stents (DESs) in the treatment of coronary artery stenosis with very long defuse lesions(VLDL). Methods Inclusion criteria: | CHEN Lianglong, LIN Chaogui, PENG Yafei, ZHANG Feilong, ZHEN Xingchun, CHEN Jianhua, YAN Xiaoping , LUO Yukun. Union Hospital, Fujian Medical University & Fujian Provincial Institute of Coronary Disease, Fuzhou 350001,China | 2007 | 上海医学2007，30，S1： | 0 |
| 9 | Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry显示文摘Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection < 0.7 fmol), linearity (correlation coefficient > 0.992), accuracy (relative error < 20%), precision (coefficient of variation (CV), CV < 15%), stability (CV < 15%), and inter-technician consistency (CV < 20%, n = 6). We also established a quantitative structure-retention relationship (goodness of fit > 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices. | Jingxian Zhang Qinsheng Chen Lianglong Zhang Biru Shi Men Yu Qingxia Huang Huiru Tang | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
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