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| 1 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 2 | Retrieving crop leaf area index by assimilation of MODIS data into a crop growth model显示文摘Leaf area index (LAI) is an important parameter in monitoring crop growth. One of the methods for retrieving LAI from remotely sensed observations is through inversion of canopy reflectance models. Many model inversion methods fail to account for variable LAI values at different crop growth stages. In this research, we use the crop growth model to describe the LAI changes with crop growth, and consider a priori LAI values at different crop growth stages as constraint information. The key approach of this research is to assimilate multiple canopy reflectance values observed at different growth stages and a priori LAI values into a coupled crop growth and radiative transfer model sequentially using a variational data assimilation algorithm. Adjoint method is used to minimize the cost function. Any other information source can be easily incorporated into the inversion cost function. The validation results show that the time series of MODIS canopy reflectance can greatly reduce the uncertainty of the inverted LAI values. Compared with MODIS LAI product at Changping and Shunyi Counties of Beijing, this method has significantly improved the estimated LAI temporal profile. | WANG DongWei1,2,3, WANG JinDi1,2 & LIANG ShunLin4 1 State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing Applications, CAS, Beijing 100875, China 2 School of Geography, Beijing Key Laboratory of Environmental Remote Sensing and Digital City, Beijing Normal University, Beijing 100875, China 3 Haihe River Water Conservancy Commission, Tianjin 300170, China 4 Department of Geography, University of Maryland, College Park, MD 20742, USA | 2010 | Science China Earth Sciences2010，53，5： | 8 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | Laparoscopic Pelvic Autonomic Nerve-Preserving Surgery for Patients with Lower Rectal Cancer after Chemoradiation Therapy显示文摘 | Jin-Tung Liang MD PhD Hong-Shiee Lai MD PhD Po-Huang Lee MD PhD | 2007 | Annals of Surgical Oncology2007，，4： | 2 |
| 5 | Suitability of 7th UICC N Stage for Predicting the Overall Survival of Gastric Cancer Patients After Curative Resection in China显示文摘 | Jingyu Deng MD Han Liang MD Dan Sun MS Dianchang Wang MD Yi Pan MD | 2010 | Annals of Surgical Oncology2010，，5： | 2 |
| 6 | Transcriptional and posttranscriptional regulation of interstitial collagenase by plateletderived growth factor BB in bone cell cultures显示文摘 | Varghese S Anne MD Liang L | 1996 | Endocrinology1996，137，2： | 1 |
| 7 | Vaccinationwith peptide mimetics of the gp41 prehairpin fusionintermediate yields neutralizing antisera against HIV-1isolates 显示文摘 | Bianchi E Joyce JG Miller MD Liang XP Finotto MA McKenna P Citron MA Hepler RW Hrin R Nahas D Wu CW Montefiori D Shiver JW Kim PS | 2010 | Proc Natl Acad Sci USA2010，107，10： | 1 |
| 8 | Percutaneous Radiofrequency Ablation Versus Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma: A Retrospective Study显示文摘 | Hui-Hong Liang MD Min-Shan Chen MD PhD Zhen-Wei Peng MD Yao-Jun Zhang MD Ya-Qi Zhang MD Jin-Qing Li MD Wan Yee Lau MD | 2008 | Annals of Surgical Oncology2008，，12： | 1 |
| 9 | TLR2 and TLR4 serve distinct roles in the host immune response against Myco- bacterium bovis BCG显示文摘 | Heldwein KA Liang MD Andresen TK Thomas KE Marty AM Cuesta N Vogel SN Fenton MJ | 2003 | J Leukoc Biol2003，74，2： | 1 |
| 10 | Toward accurate diagnosis of white matter pathology using diffusion tensor imaging 显示文摘 | Budde MD Kim JH Liang HF | 2007 | Magnetic Resonance in Medicine2007，57，4： | 1 |
| 11 | Toward accurate diagnosis of white matter pathology using diffusion tensor imaging显示文摘 | Budde MD Kim JH Liang HF | | 0，，04： | 1 |
| 12 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 13 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 14 | Hydrogen sulfide dilates cere-bral arterioles by activating smooth muscle cell plasma membraneKATP channels显示文摘 | Liang GH Adebiyi A Leo MD | 2011 | Am J Physiol Heart Circ Physiol2011，300，6： | 1 |
| 15 | Human umbilical cord stem cell en- capsulation in calcium phosphate scaffolds for bone engineering显示文摘 | Zhao Liang Weir MD Xu HH | 2010 | Biomaterials2010，31，14： | 1 |
| 16 | Hyperhomocysteinemia is associated with volumetric white matter change in patients with small vessel disease显示文摘 | A. Wong BSc V. Mok MD Y. H. Fan MD W. W. M. Lam MD K. S. Liang MD Dr. K. S. Wong | 2006 | Journal of Neurology2006，，4： | 1 |
| 17 | Phosphorylation of p27Kip1regulates assembly and activation of cyclin D1-Cdk4显示文摘 | Larrea MD Liang J Da Silva T | 2008 | Mol Cell Biol2008，28，20： | 1 |
| 18 | Presuturing-A new technique for closing large skin defects: clinical and experimental studies显示文摘 | Liang MD Briggs P Heckler FR | 1988 | Plast Reconstr Surg1988，8，： | 1 |
| 19 | Toward accurate diagnosis of white matter pathology using diffusion tensor imaging 显示文摘 | Budde MD Kim JH Liang HF | 2007 | Magn Reson Med2007，57，4： | 1 |
| 20 | Toward accurate diagno- sis of white matter pathology using diffusion tensor imaging 显示文摘 | Budde MD Kim JH Liang HF | 2007 | Magn Reson Med2007，57，4： | 1 |
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