|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury显示文摘Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ- | Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao | 2017 | Science Bulletin2017，62，11： | 29 |
| 2 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 3 | CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDACl-associated repression of C/EBPα显示文摘 | Dahu Li HengZhu Chao Liang Wenbo Li Guichun Xing Lanzhi Ma Lujing Ding Yi Zhang Fuchu He Lingqiang Zhang | 2014 | Journal of Molecular Cell Biology2014，8，5： | 4 |
| 4 | Evolution of permafrost in Northeast Chinasince the Late Pleistocene显示文摘In Northeast China, permafrost advanced and retreated several times under the influences of fluctuating paleo-climates and paleo-environments since the Late Pleistocene. During the last 60 years, many new data were obtained and studies were conducted on the evolution of permafrost in Northeast China, but so far no systematic summary and review have been made. Based on sedimentary sequences, remains of past permafrost, paleo-flora and-fauna records, and dating data, permafrost evolution since the Late Pleistocene has been analyzed and reconstructed in this paper. Paleo-temperatures reconstructed from the remains of past permafrost and those from paleo-flora and-fauna are compared, and thus the southern limit of permafrost(SLP) in each climate period is inferred by the relationship of the permafrost distribution and the mean annual air/ground temperatures(MAAT/MAGT). Thus, the evolutionary history of permafrost is here divided into five stages:(1) the Late Pleistocene(Last Glaciation, or LG)(65 to 10–8.5 ka), the Last Glaciation Maximum(LGM, 21–13 ka) in particular, the coldest period in the latest history with a cooling of about 6~10 ?C, characterized by extensive occurrences of glaciation, flourishing Mammathas-Coelodonta Faunal Complex(MCFC), widespread aeolian deposits, and significant sea level lowering, and permafrost greatly expanded southwards almost to the coastal plains(37?N–41?N);(2) the Holocene Megathermal Period(HMP, 8.5–7.0 to 4.0–3.0 ka), 3~5 ?C warmer than today, permafrost retreated to about 52°N;(3) the Late Holocene Cold Period(Neoglaciation)(4.0–3.0 to 1.0–0.5 ka), a cooling of 1~3 ?C, some earlier thawed permafrost was refrozen or attached, and the SLP invaded southwards to 46?N;(4) the Little Ice Age(LIA, 500 to 100–150 a), the latest cold period with significant permafrost expansion; and(5) climate warming since the last century, during which Northeast China has undergone extensive permafrost degradation. The frequent and substantial expansions and retreats of permafrost have greatly impacted cold-region environments in Northeast China. North of the SLP during the HMP, or in the present continuous permafrost zone, the existing permafrost was largely formed during the LG and was later overlapped by the permafrost formed in the Neoglaciation. To the south, it was formed in the Neoglaciation. However, many aspects of permafrost evolution still await further investigations, such as data integration, numerical reconstruction, and merging of Chinese permafrost history with those of bordering regions as well as collaboration with related disciplines. Of these, studieson the evolution and degradation of permafrost during the past 150 years and its hydrological, ecological, and environmental impacts should be prioritized. | HuiJun Jin XiaoLi Chang DongLiang Luo RuiXia He LanZhi Lu SiZhong Yang DongXin Guo XueMei Chen Stuart A.Harris | 2016 | Research in Cold and Arid Regions2016，8，4： | 3 |
| 5 | Evolution and changes of permafrost on the Qinghai-Tibet Plateau during the Late Quaternary显示文摘Due to the uplift of Qinghai-Tibet Plateau(QTP), the cryosphere gradually developed on the higher mountain summits after the Neocene, becoming widespread during the Late Quaternary. During this time, permafrost on the QTP experienced repeated expansion and degradation. Based on the remains and cross-correlation with other proxy records such as those from glacial landforms, ice-core and paleogeography, the evolution and changes of permafrost and environmental changes on the QTP during the past 150,000 years were deduced and are presented in this paper. At least four obvious cycles of the extensive and intensive development, expansion and decay of permafrost occurred during the periods of 150–130, 80–50, 30–14 and after 10.8 ka B.P.. During the Holocene, fluctuating climatic environments affected the permafrost on the QTP, and the peripheral mountains experienced six periods of discernible permafrost changes:(1) Stable development of permafrost in the early Holocene(10.8 to 8.5–7.0 ka B.P.);(2) Intensive permafrost degradation during the Holocene Megathermal Period(HMP, from 8.5–7.0 to 4.0–3.0 ka B.P.);(3) Permafrost expansion during the early Neoglacial period(ca. 4,000–3,000 to 1,000 a B.P.);(4) Relative degradation during the Medieval Warm Period(MWP, from 1,000 to 500 a B.P.);(5) Expansion of permafrost during the Little Ice Age(LIA, from 500 to 100 a B.P.);(6) Observed and predicted degradation of permafrost during the 20 th and 21 st century. Each period differed greatly in paleoclimate, paleoenvironment, and permafrost distribution, thickness, areal extent, and ground temperatures, as well as in the development of periglacial phenomena. Statistically, closer dating of the onset permafrost formation, more identification of permafrost remains with richer proxy information about paleoenvironment, and more dating information enable higher resolution for paleo-permafrost reconstruction. Based on the scenarios of persistent climate warming of 2.2~2.6 °C in the next 50 years, and in combination of the monitored trends of climate and permafrost changes, and model predictions suggest an accelerated regional degradation of plateau permafrost. Therefore, during the first half of the 21 st century, profound changes in the stability of alpine ecosystems and hydro(geo)logical environments in the source regions of the Yangtze and Yellow rivers may occur. The foundation stability of key engineering infrastructures and sustainable economic development in cold regions on the QTP may be affected. | XiaoLi Chang HuiJun Jin RuiXia He LanZhi Lu StuartA.Harris | 2017 | Research in Cold and Arid Regions2017，9，1： | 2 |
| 6 | Cold-region environments along the China-Russia Crude Oil Pipeline and their management显示文摘The cold-region eco-environments along the China-Russia Crude Oil Pipeline (CRCOP) in northern Northeast China are in disequilibrium due to the combined influences of pronounced climate warming and intensive anthropogenic activities.This is evidenced by the sharp areal reduction and northward shifting of the boreal forests,shrinking of wetlands,enhancing of soil erosion,accelerating degradation of permafrost and deteriorating of cold-region eco-environments.The degradation of permafrost plays an important role as an internal drive in the eco-environmental changes.Many components of the cold-region eco-environments,including frozen ground,forests,wetlands and peatlands,forest fires and 'heating island effect' of rapid urbanization,are interdependent,interactive,and integrated in the boreal ecosystems.The construction and long-term operation of the CRCOP system will inevitably disturb the cold-region environments along the pipeline.Therefore,a mandatory and carefully-elaborated environ-mental impact statement is indispensable for the proper mitigation of the ensued adverse impacts.Proper management,effective protection and practical rehabilitation of the damaged cold-region environments are a daunting,costly and long-term commitment.The recommended measures for protection and restoration of permafrost eco-environments along the pipeline route include adequate investigation,assessment and monitoring of permafrost and cold-region environments,compliance of pipeline construction and operation codes for environmental management,proper and timely re-vegetation,returning the cultivated lands to forests and grasslands,and effective mitigation of forest fire hazards. | RuiXia He HuiJun Jin LanZhi L(U) ShaoLing Wang | 2010 | Research in Cold and Arid Regions2010，2，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员