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| 1 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 2 | The Hippo signaling pathway in liver regeneration and tumorigenesis显示文摘表明小径的河马是在肝尺寸控制和 tumorigenesis 起关键作用的一个 evolutionarily 保存的发信号的模块。河马小径由在的核心 kinase 串联组成哺乳动物的象 Ste20 一样 kinases (Mst1/2,果蝇河马的 orthologs ) 并且他们的余因子萨尔瓦多(Sav1 ) 形成建筑群到 phosphorylate 并且激活大肿瘤 suppressor (Lats1/2 ) 。Lats1/2 kinases 接着 phosphorylate 并且与 PDZ 有约束力的主题(TAZ ) 禁止抄写激活剂,联系是的蛋白质(笨蛋) 和 transcriptional 激活剂,河马小径的二个主要下游的受动器。河马小径部件的损失导致异常肝肿大和 tumorigenesis,笨蛋在协调房间增长和 apoptosis 的规定并且起一个必要作用。这评论总结在肝新生和 tumorigenesis 发信号的河马的规定的当前的调查结果,集中河马小径的肿瘤 suppressor 部件的损失怎么导致肝癌症并且讨论调整它在肝 tumorigenesis 的下游的受动器笨蛋的表示和激活的分子的机制。 | Lixin Hong Yabo Cai Mingting Jiang Dawang Zhou Lanfen Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 12 |
| 3 | Remote sensing based shrub above-ground biomass and carbon storage mapping in Mu Us desert,China显示文摘The estimation of above-ground biomass(AGB) and carbon storage is very important for arid and semi-arid ecosystems.HJ-1A/B satellite data combined with field measurement data was used for the estimation of shrub AGB and carbon storage in the Mu Us desert,China.The correlations of shrub AGB and spectral reflectance of four bands as well as their combined vegetation indexes were respectively analyzed and stepwise regression analysis was employed to establish AGB prediction equation.The prediction equation based on ratio vegetation index(RVI)was proved to be more suitable for shrub AGB estimation in the Mu Us desert than others.Shrub AGB and carbon storage were mapped using the RVI based prediction model in final.The statistics showed the western Mu Us desert has relatively high AGB and carbon storage,and that the gross shrub carton storage in Mu Us desert reaches 16 799 200 t,which has greatly contributed to the carbon fixation in northern China. | XU Min 1,2,CAO ChunXiang 1,TONG QingXi 1,LI ZengYuan 3,ZHANG Hao 1,HE QiSheng 1,2,GAO MengXu 1,2,ZHAO Jian 1,2,ZHENG Sheng 1,2,CHEN Wei 1,2 & ZHENG LanFen 1 1State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China 2 Graduate School of the Chinese Academy of Sciences,Beijing 100049,China 3 Research Institute of Forest Resources and Information Techniques,Chinese Academy of Forestry,Beijing 10009,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 5 |
| 4 | Role of Hippo signaling in regulating immunity显示文摘The Hippo signaling pathway has been established as a key regulator of organ size control,tumor suppression,and tissue regeneration in multiple organisms.Recently,emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals.In particular,patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome.MST1/2 kinases,the mammalian orthologs of Drosophila Hippo,may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity.In this review,we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals,T cell immunity,as well as the implications of Hippo signaling for tumor immunity. | Lixin Hong Xun Li Dawang Zhou Jing Geng Lanfen Chen | 2018 | Cellular & Molecular Immunology2018，15，12： | 5 |
| 5 | Hippo pathway in intestinal homeostasis and tumorigenesis显示文摘The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death.Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis.Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis,regeneration and tumorigenesis,and the crosstalk between the Hippo signaling pathway and other major signaling pathways,i.e.Wnt,Notch and Jak/Stat signaling pathways in intestinal compartment. | Lanfen Chen Funiu Qin Xianming Deng Joseph Avruch Dawang Zhou | 2012 | Protein & Cell2012，3，4： | 4 |
| 6 | Genetic studies of schizophrenia:an update显示文摘Schizophrenia(SCZ) is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years,considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identifi ed. These variants include risk loci identifi ed by genome-wide association studies,rare copy-number variants identifi ed by comparative genomic analyses,and de novo mutations identified by high-throughput DNA sequencing. Collectively,they contribute to the heterogeneity of the disease. In this review,we update recent discoveries in the fi eld of SCZ genetics,and outline the perspectives of future directions. | Jingchun Chen Fei Cao Lanfen Liu Lina Wang Xiangning Chen | 2015 | Neuroscience Bulletin2015，31，1： | 3 |
| 7 | The application of hyperspectral remote sensing to coast environment investigation显示文摘Requirements for monitoring the coastal zone environment are first summarized.Then the application of hyperspectral remote sensing to coast environment investigation is introduced,such as the classification of coast beaches and bottom matter,target recognition,mine detection,oil spill identification and ocean color remote sensing.Finally,what is needed to follow on in application of hyperspectral remote sensing to coast environment is recommended. | ZHANG Liang ZHANG Bin CHEN Zhengchao ZHENG Lanfen TONG Qingxi | 2009 | Acta Oceanologica Sinica2009，28，2： | 3 |
| 8 | Molecular cloning and characterization of a gene encoding the proline transporter protein in common bean(Phaseolus vulgaris L.)显示文摘As a typical compatible solute, proline is accumulated in plants under environmental stresses. Proline transporter(Pro T) plays an important role in proline distribution between plant organs. Using a candidate gene approach, we cloned a c DNA sequence for Pro T from common bean(Phaseolus vulgaris L.) and designated the gene Pv Pro T. The deduced amino acid sequence of Pv Pro T showed high similarity to Bet/Pro T proteins from other leguminous plants, and the highest similarity was observed with mothbean(Vigna aconitifolia L.) Vu Pro T.Relative quantification of the m RNA level of Pv Pro T using real-time PCR analysis showed that the Pv Pro T transcript level was higher in leaves than in stems and roots of common bean plants subjected to drought and salt stress. Under 20%(w/w) PEG-6000 treatment,drought-resistant plants expressed a higher level of Pv Pro T transcripts than droughtsensitive plants. Although heterologous expression of Pv Pro T in the Escherichia coli mutant mkh13 showed that Pv Pro T exhibited uptake activities for proline and betaine, no betaine content was detected in the common bean. These findings suggest that Pv Pro T plays an important role in the transportation of proline in common bean plants exposed to drought and salt stress. | Jibao Chen Jing Wu Yunfeng Lu Yuannan Cao Hui Zeng Zhaoyuan Zhang Lanfen Wang Shumin Wang | 2016 | The Crop Journal2016，4，5： | 2 |
| 9 | Experiments and model for the surface tension of carbonated monoethanolamine aqueous solutions显示文摘The surface tension of carbonated monoethanolamine aqueous solutions from 293.15 to 323.15 K was measured by using an automatic surface tension-meter.A model applicable for the surface tension of MEA-CO2-water mixtures was proposed and the calculated results agreed well with the experiments.The influences of temperature,MEA concentration and CO2 loading were demonstrated on the basis of experiments and calculations. | FU Dong XU YiFei WANG LanFen CHEN LiHong | 2012 | Science China Chemistry2012，55，7： | 1 |
| 10 | Molecular identification of Anisakis and Hysterothylacium larvae in marine fishes from the East China Sea and the Pacific coast of central Japan显示文摘 | Qingming Kong Lanfen Fan Junhe Zhang Nobuaki Akao Kewei Dong Di Lou Jianzu Ding Qunbo Tong Bin Zheng Rui Chen Nobuo Ohta Shaohong Lu | 2015 | International Journal of Food Microbiology2015，，： | 1 |
| 11 | 肝肠循环因子FGF15/19调节胆汁酸代谢从而控制肝脏尺寸大小与肝癌发生显示文摘文章简介肝脏是人体的一个重要代谢器官,它的大小相对于整个个体大小始终维持在一个合适的比例。肝脏如何感知生长起始和停止是肝脏发育、再生以及癌症生物学中一个有待解决的基本科学问题。近年来研究发现,Hippo信号通路在从果蝇到哺乳动物个体的器官发育及大小调控中都起着至关重要的作用。然而具体何种外部因子在调控Hippo信号通路来维持肝脏大小稳态及抑制癌症发生,一直是领域内未解决的问题。 | 姬素渊 刘清许 张世浩 陈青花 王聪 Weiji Zhang Chen Xiao Yuxi Li Cheng Nian Jiaxin Li Junhong Li Jing Geng Lixin Hong Changchuan Xie Ying He Xing Chen Xun Li Zhen-Yu Yin Han You Kwang-Huei Lin Qiao Wu Chundong Yu Randy L.Johnson Li Wang Lanfen Chen Fen Wang 周大旺 | 2020 | 科学新闻2020，，2： | 1 |
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